(1) COP-BLAM III therapy was given to 18 patients with non-Hodgkin's lymphoma, and the therapeutic effects as well as adverse effects of the treatment were examined.
(2) COP-BLAM therapy, which has recently been reported to be useful in the treatment of malignant lymphoma, was performed on aged patients with non-Hodgkin's lymphoma, and the results and adverse effects of the treatment were evaluated.
(3) The course of disease in 61 consecutive patients with non-Hodgkin lymphoma of high grade malignancy, treated between 1979 and 1985 with either CHOP or COP-BLAM regimen, was analysed retrospectively.
(4) A full but short remission set in during a six-drug COP-BLAM treatment regimen.
(5) COP-BLAM III, an outgrowth of studies using infusional therapy, differed from COP-BLAM by using infusional bleomycin and vincristine alternated with bolus vincristine.
(6) By introducing TnblaM into bacterial cells and selecting ampicillin-resistant (ApR) colonies, the subset of isolates producing extracytoplasmic BlaM, and hence containing TnblaM inserted in genes encoding secreted proteins and cell envelope proteins, can be directly selected.
(7) COP-BLAM V employs four to six sequential cycles of infusional chemotherapy tailored to the rapidity of response.
(8) Elderly patients (aged greater than or equal to 65 years) with non-Hodgkin's lymphoma were treated either with CHOP or COP-BLAM therapy, and the effectiveness and reverse effects of COP-BLAM therapy were compared with those of CHOP therapy.
(9) Of 18 patients (median age; 68 years), who were treated with COP-BLAM therapy, 8 had of large lymphoma and 10 medium lymphomas in histopathological classification.
(10) Moreover, the ApR selection that is used with TnblaM can be fine-tuned to obtain blaM fusions to poorly or well-expressed genes.
(11) These regimens, COP-BLAM III, MACOP-B (methotrexate, doxorubicin, cyclophosphamide, vincristine, prednisone, bleomycin), ProMACE-CytaBOM (ProMACE plus cytarabine, bleomycin, vincristine, methotrexate), and high-dose doxorubicin with cytarabine, have produced over 80% CRs and survival plateaus in excess of 60%.
(12) COP-BLAM (cyclophosphamide, vincristine, prednisone, bleomycin, doxorubicin, procarbazine), M-BACOD (methotrexate, bleomycin, doxorubicin, cyclophosphamide, vincristine, dexamethasone), and ProMACE-MOPP (prednisone, methotrexate, doxorubicin, cyclophosphamide, etoposide, mechlorethamine, vincristine, procarbazine, prednisone) have produced CRs in excess of 70% and have demonstrated an increase in survival that has been associated with a concomitant increase in toxicity.
(13) The components of this system are the direct expression vector, pYZ4, and the mature beta-lactamase (BlaM) cassette plasmid, pYZ5, that can be used to generate translational fusions of BlaM to any synthesized membrane protein.
(14) Among 13 patients in advanced stage treated with COP-BLAM therapy, CR was achieved in 11 (84.6%).
(15) Preliminary results in patients with high-risk Hodgkin's disease suggest COP-BLAM V may be effective despite the shortened treatment time.
(16) Various seats and microphones cover the stage: this is a reading, not a stage adaptation; there will be no blood, just a lot of finger-guns and Tarantino yelling "blam-blam-blam!"
(17) Patients in partial remission (PR) or with less of a response to COP-BLAM were switched to IMV.
(18) The fusion protein conferred ampicillin resistance on individual host cells, indicating that the BlaM portion had been translocated to the bacterial periplasm, and that, by inference, the eukaryotic plasma-membrane protein can insert into the bacterial cytoplasmic membrane.
(19) After completion of three courses of COP-BLAM III therapy, which was started on June 7, a partial response was achieved.
(20) TnblaM is a spectinomycin-resistant derivative of Tn5 with an unexpressed open reading frame encoding mature beta-lactamase (BlaM) at its left end.
Explosive
Definition:
(a.) Driving or bursting out with violence and noise; causing explosion; as, the explosive force of gunpowder.
(n.) An explosive agent; a compound or mixture susceptible of a rapid chemical reaction, as gunpowder, or nitro-glycerine.
(n.) A sound produced by an explosive impulse of the breath; (Phonetics) one of consonants p, b, t, d, k, g, which are sounded with a sort of explosive power of voice. [See Guide to Pronunciation, Ã 155-7, 184.]
Example Sentences:
(1) According to some reports as many as 30 people were killed in the explosion, although that figure could not be independently confirmed.
(2) Recognition of this deficiency in our knowledge spurred a belated explosion of research that began with an exploration of the fine structure of the mesothelium.
(3) Moments later, explosive charges blasted free two tungsten blocks, to shift the balance of the probe so it could fly itself to a prearranged landing spot .
(4) There were soon tales of claimants dying after having had money withdrawn, but the real administrative problem was the explosion of appeals, which very often succeeded because many medical problems were being routinely ignored at the earlier stage.
(5) But late last month, Amisom pushed them out of Afgoye, a strategic stronghold 30km from Mogadishu, where Amisom officials say the militants used to manufacture explosives used in attacks on the capital.
(6) When you have champions of financial rectitude such as the International Monetary Fund and OECD warning of the international risk of an "explosion of social unrest" and arguing for a new fiscal stimulus if growth continues to falter, it's hardly surprising that tensions in the cabinet over next month's spending review are spilling over.
(7) Gunfire and explosions rocked Bangkok following clashes between pro-government "red shirts" and protesters, leading to fears of further violence as Thais head to the polls.
(8) He explained that in Iraq , vehicles loaded with explosive devices only had their hazard warning lights on.” When Fitzsimons applied for a job in Iraq with the security firm Armour Group Security , owned by G4S, he didn’t tell his family.
(9) A month later there were explosions in High Wycombe and London's King's Road.
(10) Progress on treaties underpinning nuclear disarmament – which have too long been stalled – has also recently begun to look more hopeful, with renewed prospects for achieving the entry into force of the comprehensive test ban treaty and for starting negotiations on a treaty to ban the production of fissile material for nuclear weapons or other nuclear explosive purposes.
(11) Technology assessment is becoming increasingly important in the area of critical care due both to the explosion of technology associated with this discipline and to the realization that future demand for these health care resources will undoubtedly exceed the ability to pay.
(12) Morphine was previously found to elicit an explosive excitatory behavior following its injection at a high dose in the rat periaqueductal gray (PAG).
(13) The World Health Organisation has convened an emergency committee to discuss the “explosive” spread of the Zika virus , with one of its scientists estimating there there could be 3m-4m Zika infections in the Americas over the next year.
(14) Certainly the affidavit against Ferdaus paints a compelling picture of a man hellbent on waging jihad in America and eager to take the guns and explosives eventually supplied to him by the undercover FBI agents.
(15) Thus the main population explosion – or to give it its proper name, the population implosion – is still to come.
(16) GMCs during the radiation schedule were associated with explosive diarrhea on seven occasions.
(17) The bigger question to pose is whether these reforms can possibly meet the challenge the NHS faces from an explosion in chronic diseases, such as diabetes .
(18) A massive explosion in a highly secure diplomatic area of Kabul has killed at least 90 people and wounded more than 461, Afghan officials have said.
(19) Unfortunately, this explosion is mild compared with the number of myths, falsehoods and downright lies which have accompanied these ideas.
(20) A car bomb and suspected suicide bomber have killed at least 15 people in two explosions at a restaurant in the Somali capital, Mogadishu, local police said.