(1) COP-BLAM III therapy was given to 18 patients with non-Hodgkin's lymphoma, and the therapeutic effects as well as adverse effects of the treatment were examined.
(2) COP-BLAM therapy, which has recently been reported to be useful in the treatment of malignant lymphoma, was performed on aged patients with non-Hodgkin's lymphoma, and the results and adverse effects of the treatment were evaluated.
(3) The course of disease in 61 consecutive patients with non-Hodgkin lymphoma of high grade malignancy, treated between 1979 and 1985 with either CHOP or COP-BLAM regimen, was analysed retrospectively.
(4) A full but short remission set in during a six-drug COP-BLAM treatment regimen.
(5) COP-BLAM III, an outgrowth of studies using infusional therapy, differed from COP-BLAM by using infusional bleomycin and vincristine alternated with bolus vincristine.
(6) By introducing TnblaM into bacterial cells and selecting ampicillin-resistant (ApR) colonies, the subset of isolates producing extracytoplasmic BlaM, and hence containing TnblaM inserted in genes encoding secreted proteins and cell envelope proteins, can be directly selected.
(7) COP-BLAM V employs four to six sequential cycles of infusional chemotherapy tailored to the rapidity of response.
(8) Elderly patients (aged greater than or equal to 65 years) with non-Hodgkin's lymphoma were treated either with CHOP or COP-BLAM therapy, and the effectiveness and reverse effects of COP-BLAM therapy were compared with those of CHOP therapy.
(9) Of 18 patients (median age; 68 years), who were treated with COP-BLAM therapy, 8 had of large lymphoma and 10 medium lymphomas in histopathological classification.
(10) Moreover, the ApR selection that is used with TnblaM can be fine-tuned to obtain blaM fusions to poorly or well-expressed genes.
(11) These regimens, COP-BLAM III, MACOP-B (methotrexate, doxorubicin, cyclophosphamide, vincristine, prednisone, bleomycin), ProMACE-CytaBOM (ProMACE plus cytarabine, bleomycin, vincristine, methotrexate), and high-dose doxorubicin with cytarabine, have produced over 80% CRs and survival plateaus in excess of 60%.
(12) COP-BLAM (cyclophosphamide, vincristine, prednisone, bleomycin, doxorubicin, procarbazine), M-BACOD (methotrexate, bleomycin, doxorubicin, cyclophosphamide, vincristine, dexamethasone), and ProMACE-MOPP (prednisone, methotrexate, doxorubicin, cyclophosphamide, etoposide, mechlorethamine, vincristine, procarbazine, prednisone) have produced CRs in excess of 70% and have demonstrated an increase in survival that has been associated with a concomitant increase in toxicity.
(13) The components of this system are the direct expression vector, pYZ4, and the mature beta-lactamase (BlaM) cassette plasmid, pYZ5, that can be used to generate translational fusions of BlaM to any synthesized membrane protein.
(14) Among 13 patients in advanced stage treated with COP-BLAM therapy, CR was achieved in 11 (84.6%).
(15) Preliminary results in patients with high-risk Hodgkin's disease suggest COP-BLAM V may be effective despite the shortened treatment time.
(16) Various seats and microphones cover the stage: this is a reading, not a stage adaptation; there will be no blood, just a lot of finger-guns and Tarantino yelling "blam-blam-blam!"
(17) Patients in partial remission (PR) or with less of a response to COP-BLAM were switched to IMV.
(18) The fusion protein conferred ampicillin resistance on individual host cells, indicating that the BlaM portion had been translocated to the bacterial periplasm, and that, by inference, the eukaryotic plasma-membrane protein can insert into the bacterial cytoplasmic membrane.
(19) After completion of three courses of COP-BLAM III therapy, which was started on June 7, a partial response was achieved.
(20) TnblaM is a spectinomycin-resistant derivative of Tn5 with an unexpressed open reading frame encoding mature beta-lactamase (BlaM) at its left end.
Gunshot
Definition:
(n.) Act of firing a gun; a shot.
(n.) The distance to which shot can be thrown from a gun, so as to be effective; the reach or range of a gun.
(a.) Made by the shot of a gun: as. a gunshot wound.
Example Sentences:
(1) The severity of injury in a gunshot wound is dependent on many factors, including the type of firearm; the velocity, mass, and construction of the bullet; and the structural properties of the tissues that are wounded.
(2) Seconds later the camera turns away as what sounds like at least 15 gunshots are fired amid bystanders’ screams.
(3) Long-term results of treatment of gunshot wounds of the liver are not considered to be satisfactory.
(4) In one horse, the superior aspect of the right ascending ramus of the lower jaw below the coronoid process revealed a gunshot wound; the other skeletons showed no evidence of trauma.
(5) Oleg Konstantinov, editor of local news site dumskaya.net, who was in hospital with gunshot wounds to his back and leg, and splinter wounds in his arm, said he had sent most of his reporters home for the two-day holiday.
(6) Traumatic endothelial rings were observed in the cornea obtained from a 4-year-old boy after a fatal gunshot wound to the forehead.
(7) Barry Roux, Burger added: "I heard petrified screaming before the gunshots and just after the gunshots.
(8) The case of a patient with a hepatic vein bullet embolus complicating a left ventricular gunshot injury is described.
(9) Gunshots were heard during the operation and a police officer was seen injured on a live television report on FMTV cable channel.
(10) The rough spot where protesters say shots were fired from Rice recalled in a telephone interview that he “heard gunshots go off and felt a bullet whizz by my head,” prompting him to take cover from the direction of the shots by hiding behind a car, while facing the police line.
(11) It is indicated that in vitro and at implantation in preliminary infected ordinary and gunshot osseous wounds in rabbits and dogs gentacycol inhibits the growth of aerobic and, that is especially important, anaerobic microflora, limits the development of inflammatory Process and stimulates, to a certain extent, reparative osteogenesis.
(12) Forty patients with 41 fractures of the tibia produced by civilian gunshot injuries were reviewed.
(13) Between 1980 and 1988, 127 patients with 131 low-velocity gunshot wounds to the forearm were treated.
(14) Most organisations would not send humanitarian workers into the field before discussing with them how to handle an incident of shelling or how to react when gunshots are heard.
(15) Overall mortality was 130, 8.7%; 9.5% for gunshot wounds, 3.4% for stab wounds, and 2.5% for blunt trauma.
(16) The coroner, Alan Craze, blamed poor communication and lack of organisation for the death of Lance Corporal Michael Pritchard, who was killed by a gunshot wound to the chest and abdomen in the "blue on blue" incident in Helmand province.
(17) Case report on five fatal gunshot injuries in which discharge of the cranial contents had occurred owing to a skull blast.
(18) Gunshot residue below the surface of the skin is typical of a contact gunshot wound.
(19) Nine cases of multiple-shot suicides (suicides involving more than two gunshot wounds) examined in the last 6 years at the Office of the Chief Medical Examiner.
(20) The authors report on a gunshot wound of the foot with subsequent infection and nonunion.