(1) COP-BLAM III therapy was given to 18 patients with non-Hodgkin's lymphoma, and the therapeutic effects as well as adverse effects of the treatment were examined.
(2) COP-BLAM therapy, which has recently been reported to be useful in the treatment of malignant lymphoma, was performed on aged patients with non-Hodgkin's lymphoma, and the results and adverse effects of the treatment were evaluated.
(3) The course of disease in 61 consecutive patients with non-Hodgkin lymphoma of high grade malignancy, treated between 1979 and 1985 with either CHOP or COP-BLAM regimen, was analysed retrospectively.
(4) A full but short remission set in during a six-drug COP-BLAM treatment regimen.
(5) COP-BLAM III, an outgrowth of studies using infusional therapy, differed from COP-BLAM by using infusional bleomycin and vincristine alternated with bolus vincristine.
(6) By introducing TnblaM into bacterial cells and selecting ampicillin-resistant (ApR) colonies, the subset of isolates producing extracytoplasmic BlaM, and hence containing TnblaM inserted in genes encoding secreted proteins and cell envelope proteins, can be directly selected.
(7) COP-BLAM V employs four to six sequential cycles of infusional chemotherapy tailored to the rapidity of response.
(8) Elderly patients (aged greater than or equal to 65 years) with non-Hodgkin's lymphoma were treated either with CHOP or COP-BLAM therapy, and the effectiveness and reverse effects of COP-BLAM therapy were compared with those of CHOP therapy.
(9) Of 18 patients (median age; 68 years), who were treated with COP-BLAM therapy, 8 had of large lymphoma and 10 medium lymphomas in histopathological classification.
(10) Moreover, the ApR selection that is used with TnblaM can be fine-tuned to obtain blaM fusions to poorly or well-expressed genes.
(11) These regimens, COP-BLAM III, MACOP-B (methotrexate, doxorubicin, cyclophosphamide, vincristine, prednisone, bleomycin), ProMACE-CytaBOM (ProMACE plus cytarabine, bleomycin, vincristine, methotrexate), and high-dose doxorubicin with cytarabine, have produced over 80% CRs and survival plateaus in excess of 60%.
(12) COP-BLAM (cyclophosphamide, vincristine, prednisone, bleomycin, doxorubicin, procarbazine), M-BACOD (methotrexate, bleomycin, doxorubicin, cyclophosphamide, vincristine, dexamethasone), and ProMACE-MOPP (prednisone, methotrexate, doxorubicin, cyclophosphamide, etoposide, mechlorethamine, vincristine, procarbazine, prednisone) have produced CRs in excess of 70% and have demonstrated an increase in survival that has been associated with a concomitant increase in toxicity.
(13) The components of this system are the direct expression vector, pYZ4, and the mature beta-lactamase (BlaM) cassette plasmid, pYZ5, that can be used to generate translational fusions of BlaM to any synthesized membrane protein.
(14) Among 13 patients in advanced stage treated with COP-BLAM therapy, CR was achieved in 11 (84.6%).
(15) Preliminary results in patients with high-risk Hodgkin's disease suggest COP-BLAM V may be effective despite the shortened treatment time.
(16) Various seats and microphones cover the stage: this is a reading, not a stage adaptation; there will be no blood, just a lot of finger-guns and Tarantino yelling "blam-blam-blam!"
(17) Patients in partial remission (PR) or with less of a response to COP-BLAM were switched to IMV.
(18) The fusion protein conferred ampicillin resistance on individual host cells, indicating that the BlaM portion had been translocated to the bacterial periplasm, and that, by inference, the eukaryotic plasma-membrane protein can insert into the bacterial cytoplasmic membrane.
(19) After completion of three courses of COP-BLAM III therapy, which was started on June 7, a partial response was achieved.
(20) TnblaM is a spectinomycin-resistant derivative of Tn5 with an unexpressed open reading frame encoding mature beta-lactamase (BlaM) at its left end.
Slam
Definition:
(v. t.) To shut with force and a loud noise; to bang; as, he slammed the door.
(v. t.) To put in or on some place with force and loud noise; -- usually with down; as, to slam a trunk down on the pavement.
(v. t.) To strike with some implement with force; hence, to beat or cuff.
(v. t.) To strike down; to slaughter.
(v. t.) To defeat (opponents at cards) by winning all the tricks of a deal or a hand.
(v. i.) To come or swing against something, or to shut, with sudden force so as to produce a shock and noise; as, a door or shutter slams.
(n.) The act of one who, or that which, slams.
(n.) The shock and noise produced in slamming.
(n.) Winning all the tricks of a deal.
(n.) The refuse of alum works.
Example Sentences:
(1) To selectively stain polyanionic macromolecules of growth plate cartilage and to prevent artifacts induced by aqueous fixation, proximal tibial growth plates were excised from rats, slam-frozen, and freeze-substituted in 100% methanol containing the cationic dye Alcian blue.
(2) "More than most British players, I have been asked about it many times when I got close to winning grand slams before.
(3) At that point I was grabbed by the Belgian secret service and slammed against the glass.
(4) When he first became president, Republicans slammed him for being a socialist – an epithet, from their lips, of the worst kind.
(5) Seeb slams a copy of their licence application on the table – it's well over an inch thick.
(6) They've all had the courthouse doors slammed shut in the faces by courts that have accepted the US government's claims that its own secrecy powers and immunity rights bar any such justice.
(7) After a dramatic pause that would have done Harold Pinter proud, Andy Murray has appointed Ivan Lendl as his coach, a move he hopes will bring him his first grand slam victory in the Australian Open, which starts on 16 January.
(8) I’ve lost slam finals and stuff, which has been very tough.
(9) There are going to be downs and I'll lose close matches, but I hope I'll be in a position to play for grand slams in the future.
(10) The chancellor stressed that Britain’s relationship with the EU would remain unchanged for the time being – and ditched the idea, launched alongside his predecessor Alistair Darling during the campaign – that an emergency budget would be necessary within weeks, as Brexit slams the brakes on the economy.
(11) Six systems for defining and evaluating disease activity in patients with systemic lupus erythematosus (SLE) (the Ropes system, the National Institutes of Health [NIH] system, the New York Hospital for Special Surgery system, the British Isles Lupus Assessment Group [BILAG] scale, the University of Toronto SLE Disease Activity Index [SLE-DAI], and the Systemic Lupus Activity Measure [SLAM]) were tested on 25 SLE patients who were selected to represent a range of disease activity.
(12) Given the paucity of British talent in the sport over recent decades, it is a tribute to Murray's remarkable consistency that in his last eight grand slam tournaments, he has reached three finals, four semi-finals and a quarter-final – not to mention overcoming Federer on Wimbledon's Centre Court to win a gold medal at the Olympics.
(13) Andy McDonald, the shadow transport secretary, said: “In opposition the Tories slammed the closure of lines over Christmas for engineering works, but now they’re in a position to do something about it they don’t seem to care.
(14) She has also slammed the “illogical and outright offensive” language used by those against same-sex marriage.
(15) The grand slam champions so far this year are myself and Li Na [in the Australian Open],” she said.
(16) People tend to forget he is playing in an era with 3 players who are likely to be remembered as three of the all-time greatest, so the fact that he is managing to win slams is fairly amazing, and something that won’t be properly appreciated until he retires.
(17) ‘Dysfunctional’ ABC management slammed Trevor Bormann, last year’s Walkley winner for Foreign Correspondent’s “Prisoner X” scoop, has dumped a bucket on ABC news management on the way out the door.
(18) This week people around the internet have taken to photoshopping WWE wrestler Randy Orton’s famous head slam move on to videos of people falling over.
(19) In fact, the whole thing could have been worse had it not been for Carlos Beltran stealing a grand slam away from David Ortiz in the second inning.
(20) Following narrow defeat at the All England Club, Murray provided a glorious coda in the early hours of Tuesday morning with a US Open victory in his fifth grand slam final.