(n.) State or condition of being blind, literally or figuratively.
Example Sentences:
(1) Clonazepam was added to the treatment of patients with poorly controlled epilepsy in a double-blind trial and an open trial.
(2) One rare case of blind-ending branch originating in the upper third of the ureter are described.
(3) We report the results of a double-blind, placebo-controlled trial of acitretin (Soriatane) in 15 patients with moderate to severe psoriasis.
(4) In a double-blind, crossover-designed study, 9 male subjects (age range: 18-25 years) received 25 mg orally, four times per day of either S or an identically-appearing placebo (P) 2 d prior to and during HA.
(5) In a randomized double-blind study, 40 patients with coronary heart disease received intravenously either 0.025 mg nitroglycerin or placebo.
(6) Eighty micrograms of the topically active parasympatholytic drug ipratropium were applied intranasally four times daily in 20 adults with perennial rhinitis and severe watery rhinorrhoea in a double-blind controlled cross-over trial.
(7) The effect of ipratropium bromide administered at two dosage levels, 40 and 80 mug, isoproterenol, 150 mug, and placebo using a metered dose inhaler was evaluated in ten adult patients with asthma in a double-blind, crossover study.
(8) The epidemiological effectiveness of dipyridamol, an interferon-inducing agent used for the prevention of influenza and viral acute respiratory diseases, was tested in 4 epidemiological trials, 3 of them carried out as double blind trials.
(9) These lanes encourage cyclists to 'ride in the gutter' which in itself is a very dangerous riding position – especially on busy congested roads as it places the cyclist right in a motorist's blind spot.
(10) A randomised double-blind trial comparing this preparation with a so-called 'shotgun' combination containing 0.05% betamethasone 17-valerate, 0.1% gentamicin, 1.0% tolnaftate and 1.0% clioquinol in 288 patients in the Philippines resulted in a better efficacy for the diflucortolone preparation in the 80 patients with bacterially or mycotically infected skin diseases.
(11) Blinded outcomes of depression and cognition were measured initially and twice in each phase.
(12) Therefore, two-dimensional echocardiographic findings in 22 patients with perivalvular abscess found at surgery or necropsy were compared with those in 24 patients without abscess in a retrospective but blinded study.
(13) In a double-blind trial, 50 patients with subcostal incisions performed for cholecystectomy or splenectomy, received 10 ml of either 0.5% bupivacaine plain or physiological saline twice daily by wound perfusion through an indwelling drainage tube for 3 days after operation.
(14) In a double-blind, randomized, within-patient comparative study, the efficacy and tolerability of Ro 14-9706 (an arotinoid methyl sulfone) in the treatment of actinic keratoses was compared with that of tretinoin (all-trans-retinoic acid).
(15) Eighteen adult epileptic patients under CBZ therapy were evaluated in this single-blind, randomized cross-over study.
(16) A total of 17 patients suffering from musculoskeletal disease were included in a double blind study to compare the efficacy and safety of piroxicam and indomethacin.
(17) Each subject applied a vehicle cream containing 0.075% capsaicin (Axsain, GalenPharma Inc.) to a 4 cm2 area of skin on one volar forearm and vehicle alone to an identical treatment area on the other forearm, according to a double-blind procedure.
(18) A prospective, double-blind study was undertaken to assess the effectiveness of oral dexamethasone premedication in reducing a variety of side effects associated with metrizamide myelography.
(19) They then entered, on a randomized and double-blind basis, a cross-over trial of two 16-week periods, blood pressure being measured fortnightly.
(20) The design was a single-blind randomised controlled study.
Unblind
Definition:
(v. t.) To free from blindness; to give or restore sight to; to open the eyes of.
Example Sentences:
(1) In an unblinded, randomized parallel group trial three different therapeutic dose schedules of fenticonazole (vaginal ovules) were compared in the treatment of vaginal candidiasis.
(2) The limits of detectability were tested in a blinded, then unblinded analysis of CT scans from 25 acute stroke patients.
(3) In the past, stereotactic surgery was a regular treatment for prominent unilateral tremor in Parkinson's disease (PD), but follow-up studies were usually short-term and always unblinded.
(4) Ivermectin (19 'double-blinded' and 22 'unblinded' patients) caused an abrupt reduction in mf count to 1.5% of the pre-treatment level 12 h after drug administration and to 0.06% on day 14, with recrudescence to 1.8% after one month and to 9.2% after 3 months.
(5) The unblinded second phase involved the steady state conditions using halothane or isoflurane and atracurium infusions.
(6) Babies in either group developing RDS during the following 18 hours received 2 unblinded doses of surfactant 12 hours apart.
(7) An unblinded, in vitro trial simulating clinical conditions.
(8) These results suggest that in double-blind studies, differences in outcome or incidence of adverse drug reactions may act as unblinding factors.
(9) The results of this study differed substantially from previous unblinded studies; therefore, it is suggested that a randomized, double-blind design with simultaneous succinylcholine controls be considered a prerequisite for future studies of intubation conditions.
(10) In an adjunctive, unblinded trial, the same patients received 400 micrograms fenoterol.
(11) These findings suggest that the effects of unblinding should be considered when alcohol is administered in placebo designs.
(12) Prolonged unblinded passive surveillance of the trial cohort from the Swedish 1986-87 pertussis vaccine efficacy trial indicates that a two-component vaccine, containing pertussis toxoid and filamentous haemagglutinin, provided better long-term protection against pertussis than a monocomponent pertussis toxoid vaccine.
(13) We therefore tested the long-term effect of metoprolol on eight patients in a double-blind, randomized protocol and 12 patients in an unblinded, crossover protocol who were treated for 12 months (range 10 to 24), and compared them with 16 similar subjects who were treated with placebo for 10 months (range 6 to 12) in a double-blind, randomized protocol.
(14) One hundred five early babies and 142 selective babies developed RDS requiring unblinded surfactant (50% versus 68%; 95% CI of difference, 9% to 27%).
(15) There was no evidence for the development of resistance to polyenes or imidazoles in fungal isolates recovered from patients in this randomized trial or an increase in Aspergillus infections in patients who received miconazole in this randomized trial or in 121 subsequently treated patients who received unblinded use of miconazole.
(16) A blinded interpretation of the pretherapy and posttherapy noise-added images was performed in the same way as the initial unblinded interpretation.
(17) Blinded and unblinded readers analyzed brain and spine MRI studies from a multicenter clinical trial involving 101 patients at 11 sites.
(18) A survey of two cohorts of patients with AIDS who participated in nonrandomized, unblinded, non-placebo-controlled investigations of the toxicity and efficacy of interleukin-2 and interferon-gamma.
(19) Six months after lithotripsy, patients receiving placebo were crossed over to UDCA therapy without unblinding the study.
(20) The bioavailability and in vitro pharmacokinetic characteristics of this novel PPA preparation were compared with those of a reference sustained-release 75 mg Q16 PPA tablet (Acutrim), in a pilot, 3 subject, unblinded, cross-over, single dose study.