(v. t.) The shutting up of a place by troops or ships, with the purpose of preventing ingress or egress, or the reception of supplies; as, the blockade of the ports of an enemy.
(v. t.) An obstruction to passage.
(v. t. ) To shut up, as a town or fortress, by investing it with troops or vessels or war for the purpose of preventing ingress or egress, or the introduction of supplies. See note under Blockade, n.
(n.) Hence, to shut in so as to prevent egress.
(n.) To obstruct entrance to or egress from.
Example Sentences:
(1) In dogs, cibenzoline given i.v., had no effects on the slow response systems, probably because of sympathetic nervous system intervention since the class 4 effects of cibenzoline appeared after beta-adrenoceptor blockade.
(2) The blockade of H2 receptors is the primary action of these drugs; however, they possess also secondary actions which may represent untoward effects but in some cases may be actually useful (increase in prostaglandin synthesis, inhibition of LTB4 synthesis, etc.)
(3) With profound blockade, the slope of the edrophonium dose-response relationship was significantly flatter (P less than 0.05) than that of neostigmine.
(4) Subthreshold concentrations of the drug to induce complete blockade (5 x 10(-8)M) allowed to observe a greater depression of bioelectric cell characteristics in primary than in transitional fibres.
(5) At 100 microM-ACh the apparent open time became shorter probably due to channel blockade by ACh molecules.
(6) The Ca2+ channel current recorded under identical conditions in rat dorsal root ganglion neurones was less sensitive to blockade by PCP (IC50, 90 microM).
(7) Propranolol, 0.85 X 10(-6) M, did not significantly depress the ouabain-enhanced rate of phase 4 depolarization but did attenuate the response to epinephrine through beta blockade.
(8) Adding prazosin (30 nM) to the perfusate completely (approximately 90%) reversed this effect (p less than 0.05), while alpha 2-adrenergic receptor blockade with yohimbine (300 nM) had no effect.
(9) In the case of unilateral blockade at the groin or pelvis, the grafts connect the lymphatics of the thigh of the affected leg with lymphatics in the contralateral healthy groin.
(10) Ten patients received intercostal nerve blockade on a total of 29 occasions in order to provide analgesia following liver transplantation and to facilitate weaning from artificial ventilation of the lungs.
(11) beta-Adrenergic blockade and Ca2+ antagonists markedly suppressed Ca2+ influx, phospholipase A2 activity, phospholipase C activity and cell death.
(12) Blockade of beta-adrenoceptors interferes with haemodynamic and metabolic adaptations and ion balance during dynamic exercise.
(13) The fractional rate constants for the accumulation or disappearance of the metabolites could be determined after pharmacological blockade of catabolic enzymes or the acid metabolite carrier.
(14) Free radical generation did not antagonise the antiarrhythmic activity of alpha adrenergic blockade.
(15) At these high doses, doxepin may cause orthostatic hypotension via a peripheral alpha-receptor blockade.
(16) In order to increase the efficiency of androgen blockade, we have used 4-MA, an inhibitor of 5 alpha-reductase, the enzyme which converts testosterone into DHT, to reduce intracellular DHT concentrations and thus facilitate the action of the antiandrogen Flutamide.
(17) As stimulus rate was decreased, blockade of secretion resulted from fewer stimuli but no difference in ACh content was found between stimulated and unstimulated glands.
(18) This phenomenon is similar in many respects to the antigen-induced blockade of normal antibody-secreting cells, and provides a valuable model system for analyzing the mechanisms of antigen-mediated cellular inactivation.
(19) The anesthesiologist assessed the degree of neuromuscular blockade intraoperatively prior to pharmacologic reversal either by the standard method of visually counting the number of evoked thumb twitches elicited by supramaximal train-of-four stimulation of the ulnar nerve (i.e., thumb train-of-four count), or by an alternative method such as 1) visually counting the number of evoked orbicularis oculi muscle twitches elicited by supramaximal train-of-four stimulation of the facial nerve, or 2) observing the patient for clinical evidence of partial recovery (e.g., swallowing or attempts to breathe).
(20) In conclusion, block of inhibitory innervation, and induction of electrical slow waves as a control mechanism for phasic contractile activity, seems to require blockade of an aminacrine- but not TEA-sensitive potassium conductance.
Shutter
Definition:
(n.) One who shuts or closes.
(n.) A movable cover or screen for a window, designed to shut out the light, to obstruct the view, or to be of some strength as a defense; a blind.
(n.) A removable cover, or a gate, for closing an aperture of any kind, as for closing the passageway for molten iron from a ladle.
Example Sentences:
(1) I watched as she made the briefest eye contact with me on their way back, the flicker of hurt and sadness in her eyes reflecting mine, before the shutters came down.
(2) After they were shuttered, they were supposed to be replaced by community outreach programs.
(3) They also need to pass a bill to reopen the federal government, which has been partially shuttered for 14 days now (it closed on 1 October).
(4) If photographs are taken of moving objects at slow shutter speeds the images of the objects are blurred.
(5) Animal Rescue is based on a screenplay by the novelist Dennis Lehane , author of Gone Baby Gone, Mystic River and Shutter Island, all of which have been made into films by Hollywood.
(6) A PLZT electrooptic shutter stereoradiology system in which dual x-ray tubes are used to generate stereo pairs of fluoroscopic images is presented.
(7) Comet, the electricals retailer that has collapsed into administration, is the latest high street casualty, emblematic of thousands of shuttered shops up and down the land.
(8) H2 is now a near-ghost town: shuttered shops, empty houses, deserted streets, packs of wild dogs, and armed soldiers on most street corners.
(9) So all these things are going through your head as I'm on my belly crawling to get underneath this shutter.
(10) Conveniently, it is not far from the Via Algarviana , allowing us to leave the car and hike the stretch to Alte (16km), passing shuttered houses smothered in creepers in old, abandoned villages.
(11) The ceasefire, declared on Monday night, had brought a palpable sense of relief and optimism to Gaza, but on Friday streets were deserted once more and any shops that had opened were hastily bring down their shutters.
(12) With five police officers standing guard outside the room, and more on the street below where the iron shutters had been closed since Wednesday, a delivery of computers was accepted on loan from Le Monde, the heating was turned up and the windows were opened to let the team smoke.
(13) In the small hours of the previous morning, an attacker had forced open a shutter, broken a window and set the inside alight .
(14) The results tended to overestimate RGF by up to 10 percent points, when image contrast was high and the ventricle was masked poorly by the lead shutters.
(15) All told, the 30-year space shuttle program cost nearly $200bn before it was shuttered in July 2011.
(16) Our guide extinguished the light and began to open the shutter, rotating the lens with a brass handle.
(17) Next to Cannabis City, a shuttered business advertised liquidation sales.
(18) It is painted all in black, save for three steel roller shutters that each represent a juncture of White's life: one is yellow, a nod to the livery of the upholstery business he started when he was 21; the second is red, the signature colour of his blues-rock band, the White Stripes; the last is blue, the colour he has latterly adopted for his solo career.
(19) Shops were closed, some shopping malls were shuttered, professional football was cancelled, concerts were called off and music venues, museums, and galleries shut their doors for the weekend.
(20) "Like one person can't lift up a shutter, so to come together and become one big group and be able to lift up something's that heavy like that, it just shows that people can work together.