(n.) Forward to meet danger; venturesome; daring; not timorous or shrinking from risk; brave; courageous.
(n.) Exhibiting or requiring spirit and contempt of danger; planned with courage; daring; vigorous.
(n.) In a bad sense, too forward; taking undue liberties; over assuming or confident; lacking proper modesty or restraint; rude; impudent.
(n.) Somewhat overstepping usual bounds, or conventional rules, as in art, literature, etc.; taking liberties in composition or expression; as, the figures of an author are bold.
(n.) Standing prominently out to view; markedly conspicuous; striking the eye; in high relief.
(n.) Steep; abrupt; prominent.
(v. t.) To make bold or daring.
(v. i.) To be or become bold.
Example Sentences:
(1) Obamacare price hikes show that now is the time to be bold | Celine Gounder Read more No longer able to keep patients off their plans outright, insurers have resorted to other ways to discriminate and avoid paying for necessary treatments.
(2) Moments later, Strauss introduces the bold human character with an energetic, upwards melody which he titles "the climb" in the score.
(3) And that is why we have taken bold action at home – by making historic investments in renewable energy; by putting our people to work increasing efficiency in our homes and buildings; and by pursuing comprehensive legislation to transform to a clean energy economy.
(4) No doubt it was intended as a bold and graphic way of presenting the Iranian nuclear threat, but much of the initial response – on Twitter, at least – was ridicule.
(5) Noonan was also bold in his projection for Irish economic growth by 3.9% for 2015, which is higher than the original 2.7% growth predicted back in April this year.
(6) He Peirong has been at the forefront of a bold and innovative campaign by Chinese activists to free Chen and his family from their lengthy captivity.
(7) But Di Matteo has made bold selections before, not least when he asked Ramires to play on the left of midfield against Barcelona in an attempt to nullify the threat posed by the marauding Daniel Alves down the flank.
(8) But Sanders, 73, rejected the idea his appeal is limited to voters on the left, boldly predicting on Wednesday that his message would appeal to both fellow independents and Republicans.
(9) Read more The agreement earned a mixed initial reception, with the UN hailing a “bold” and “groundbreaking” outcome even as other delegates complained of “a terrible precedent” and lack of moral leadership.
(10) There is effective use of a scuba-like neoprene fabric which is slickly practical and gives a bold, shell-like silhouette to hooded coats and to sweatshirts which seems to reference the balloon and cocoon shapes that Cristobal Balenciaga invented to great acclaim in the 1950s.
(11) Previously a cover-up and reworking of a tattoo beneath, when she was performing across the UK with Girls Aloud in February , you could see the bold work in progress poking above her backless stage costumes.
(12) Blowing up the flats will on the one hand "serve as an unforgettable statement of how Glasgow is confidently embracing the future and changing for the better", while on the other it will "serve as a respectful recognition and celebration of the role the Red Road flats have played in shaping the lives of thousands of city families for whom these flats have simply been home … " According to David Zolkwer, who as the games' artistic director may have had the idea, the demolition will be "a bold and confident statement that says: 'Bring on the future'."
(13) But the equaliser was fair reward for the best move of the game and for Strachan’s own boldness in putting a player on to push back Séamus Coleman on Ireland’s right.
(14) Carney will have to defend his bold pledge to peg UK interest rates to their current record low of 7% until unemployment rate has dropped to 7%, sometime in 2016 by the Bank's reckoning.
(15) But US security experts criticised the administration for appearing to time its intervention to suit conflicting agendas of the Asean and Paris summits rather than more boldly assert the principle of freedom of navigation.
(16) Charlotte Emma Aitchison suits the bold, bratty music she makes.
(17) Advising renegotiation was "a bold recommendation" but showed the depth of backbench feeling on the issue, he added: "This is a joint committee of the Lords and the Commons, with a coalition government majority, and it's a unanimous report."
(18) The only Newcastle player that regularly took initiatives in the first half was Andros Townsend but he lacked the accuracy to make good on bold intentions.
(19) In 2007 a fresh-faced MP spent two days at the home of a Muslim family in Birmingham and then wrote boldly of how it wasn’t possible to “bully people into feeling British: we have to inspire them”; “you can’t even start to talk about a truly integrated society while people are suffering racist … abuse … on a daily basis”.
(20) After meeting the summit host, the president of the Philippines, Obama said the US and Manila had agreed on the need for “bold steps to lower tensions, including pledging to halt reclamation, new construction and militarisation of disputed islands in the South China Sea”.
Fold
Definition:
(v. t.) To lap or lay in plaits or folds; to lay one part over another part of; to double; as, to fold cloth; to fold a letter.
(v. t.) To double or lay together, as the arms or the hands; as, he folds his arms in despair.
(v. t.) To inclose within folds or plaitings; to envelop; to infold; to clasp; to embrace.
(v. t.) To cover or wrap up; to conceal.
(v. i.) To become folded, plaited, or doubled; to close over another of the same kind; to double together; as, the leaves of the door fold.
(v.) A doubling,esp. of any flexible substance; a part laid over on another part; a plait; a plication.
(v.) Times or repetitions; -- used with numerals, chiefly in composition, to denote multiplication or increase in a geometrical ratio, the doubling, tripling, etc., of anything; as, fourfold, four times, increased in a quadruple ratio, multiplied by four.
(v.) That which is folded together, or which infolds or envelops; embrace.
(n.) An inclosure for sheep; a sheep pen.
(n.) A flock of sheep; figuratively, the Church or a church; as, Christ's fold.
(n.) A boundary; a limit.
(v. t.) To confine in a fold, as sheep.
(v. i.) To confine sheep in a fold.
Example Sentences:
(1) Patient plasma samples demonstrated evidence of marked complement activation, with 3-fold elevations of C3a desArg concentrations by the 8th day of therapy.
(2) 5-Azacytidine (I) stability was increased approximately 10-fold over its stability in water or lactated Ringer injection by the addition of excess sodium bisulfite and the maintenance of pH approximately 2.5.
(3) Radioligand binding studies revealed the presence of a single class of high-affinity (Kd = 2-6 X 10(-10) M) binding sites for ET-1 in both cells, although the maximal binding capacity of cardiac receptor was about 6- to 12-fold greater than that of vascular receptor.
(4) The enzyme was solubilized by Triton X-100 and purified approximately 480-fold by gel filtration and affinity chromatography on alanine methyl ketone-AH-Sepharose 4B.
(5) The DNA untwisting enzyme has been purified approximately 300-fold from rat liver nuclei.
(6) IP3 increased 1.7-fold and IP2 1.6-fold after 20 and 40 s, respectively.
(7) Short incubations with heparin (5 min) caused a release of the enzyme into the media, while longer incubations caused a 2-8-fold increase in net lipoprotein lipase secretion which was maximal after 2-16 h depending on cell type, and persisted for 24 h. The effect of heparin was dose-dependent and specific (it was not duplicated by other glycosaminoglycans).
(8) The following conclusions emerge: (i) when the 3' or the 3' penultimate base of the oligonucleotide mismatched an allele, no amplification product could be detected; (ii) when the mismatches were 3 and 4 bases from the 3' end of the primer, differential amplification was still observed, but only at certain concentrations of magnesium chloride; (iii) the mismatched allele can be detected in the presence of a 40-fold excess of the matched allele; (iv) primers as short as 13 nucleotides were effective; and (v) the specificity of the amplification could be overwhelmed by greatly increasing the concentration of target DNA.
(9) Epicanthal folds were present in 46%, mongoloid slanting of the lids in 72% of cases.
(10) The estimated DNA compaction ratio (approximately 3-fold) is consistent with a significant degree of nucleosome unfolding in the hyperstimulated BR genes.
(11) Two hours after refeeding rats fasted for 48 h, ODC activity increased 40-fold in mucosa from the intact jejunum and 4-fold in the mucosa of the bypassed segments.
(12) Transfection of the treated DNA into SOS-induced spheroplasts results in an increase in mutagenesis as great as 50-fold.
(13) ACh released from the vesicular fraction was about 100-fold more than could be accounted for by miniature end-plate potentials; possible causes of this overestimate are discussed.
(14) In strains completely deleted for galR, the gene which encodes the Gal repressor, the operon is derepressed by only 10-fold without an inducer.
(15) The amount of water, creatinine, electrolytes, proteins, and enzymes were higher during the day (up to three fold, p always less than 0.05), while equal amounts of amino acids were excreted in the day and the night period.
(16) TNBS reacts to an extremely small extend with hemoglobin over the concentration range 0.4 to 4 mM whereas FDNB reacts with hemoglobin to a very large extent (50 fold more than TNBS).
(17) Rates of PC in vitro metabolism by liver and kidney cytosolic cysteine conjugate beta-lyases (beta-lyases) were similar, but metabolism by renal mitochondrial beta-lyase occurred at a 3-fold higher rate than the rate obtained with hepatic mitochondrial beta-lyase.
(18) Dietary factors affect intestinal P450s markedly--iron restriction rapidly decreased intestinal P450 to beneath detectable values; selenium deficiency acted similarly but was less effective; Brussels sprouts increased intestinal AHH activity 9.8-fold, ECOD activity 3.2-fold, and P450 1.9-fold; fried meat and dietary fat significantly increased intestinal EROD activity; a vitamin A-deficient diet increased, and a vitamin A-rich diet decreased intestinal P450 activities; and excess cholesterol in the diet increased intestinal P450 activity.
(19) On the other hand, if we correct for the population of HMM with degraded light chain 2, the difference in the binding constants in the presence and absence of Ca2+ may be as great as 5-fold.
(20) The gene, which is located at chromosome XIII, is transcribed as a mRNA of about 2.7 kilobases, and the amount of message has been found to increase 3- to 4-fold during the culture.