(n.) Forward to meet danger; venturesome; daring; not timorous or shrinking from risk; brave; courageous.
(n.) Exhibiting or requiring spirit and contempt of danger; planned with courage; daring; vigorous.
(n.) In a bad sense, too forward; taking undue liberties; over assuming or confident; lacking proper modesty or restraint; rude; impudent.
(n.) Somewhat overstepping usual bounds, or conventional rules, as in art, literature, etc.; taking liberties in composition or expression; as, the figures of an author are bold.
(n.) Standing prominently out to view; markedly conspicuous; striking the eye; in high relief.
(n.) Steep; abrupt; prominent.
(v. t.) To make bold or daring.
(v. i.) To be or become bold.
Example Sentences:
(1) Obamacare price hikes show that now is the time to be bold | Celine Gounder Read more No longer able to keep patients off their plans outright, insurers have resorted to other ways to discriminate and avoid paying for necessary treatments.
(2) Moments later, Strauss introduces the bold human character with an energetic, upwards melody which he titles "the climb" in the score.
(3) And that is why we have taken bold action at home – by making historic investments in renewable energy; by putting our people to work increasing efficiency in our homes and buildings; and by pursuing comprehensive legislation to transform to a clean energy economy.
(4) No doubt it was intended as a bold and graphic way of presenting the Iranian nuclear threat, but much of the initial response – on Twitter, at least – was ridicule.
(5) Noonan was also bold in his projection for Irish economic growth by 3.9% for 2015, which is higher than the original 2.7% growth predicted back in April this year.
(6) He Peirong has been at the forefront of a bold and innovative campaign by Chinese activists to free Chen and his family from their lengthy captivity.
(7) But Di Matteo has made bold selections before, not least when he asked Ramires to play on the left of midfield against Barcelona in an attempt to nullify the threat posed by the marauding Daniel Alves down the flank.
(8) But Sanders, 73, rejected the idea his appeal is limited to voters on the left, boldly predicting on Wednesday that his message would appeal to both fellow independents and Republicans.
(9) Read more The agreement earned a mixed initial reception, with the UN hailing a “bold” and “groundbreaking” outcome even as other delegates complained of “a terrible precedent” and lack of moral leadership.
(10) There is effective use of a scuba-like neoprene fabric which is slickly practical and gives a bold, shell-like silhouette to hooded coats and to sweatshirts which seems to reference the balloon and cocoon shapes that Cristobal Balenciaga invented to great acclaim in the 1950s.
(11) Previously a cover-up and reworking of a tattoo beneath, when she was performing across the UK with Girls Aloud in February , you could see the bold work in progress poking above her backless stage costumes.
(12) Blowing up the flats will on the one hand "serve as an unforgettable statement of how Glasgow is confidently embracing the future and changing for the better", while on the other it will "serve as a respectful recognition and celebration of the role the Red Road flats have played in shaping the lives of thousands of city families for whom these flats have simply been home … " According to David Zolkwer, who as the games' artistic director may have had the idea, the demolition will be "a bold and confident statement that says: 'Bring on the future'."
(13) But the equaliser was fair reward for the best move of the game and for Strachan’s own boldness in putting a player on to push back Séamus Coleman on Ireland’s right.
(14) Carney will have to defend his bold pledge to peg UK interest rates to their current record low of 7% until unemployment rate has dropped to 7%, sometime in 2016 by the Bank's reckoning.
(15) But US security experts criticised the administration for appearing to time its intervention to suit conflicting agendas of the Asean and Paris summits rather than more boldly assert the principle of freedom of navigation.
(16) Charlotte Emma Aitchison suits the bold, bratty music she makes.
(17) Advising renegotiation was "a bold recommendation" but showed the depth of backbench feeling on the issue, he added: "This is a joint committee of the Lords and the Commons, with a coalition government majority, and it's a unanimous report."
(18) The only Newcastle player that regularly took initiatives in the first half was Andros Townsend but he lacked the accuracy to make good on bold intentions.
(19) In 2007 a fresh-faced MP spent two days at the home of a Muslim family in Birmingham and then wrote boldly of how it wasn’t possible to “bully people into feeling British: we have to inspire them”; “you can’t even start to talk about a truly integrated society while people are suffering racist … abuse … on a daily basis”.
(20) After meeting the summit host, the president of the Philippines, Obama said the US and Manila had agreed on the need for “bold steps to lower tensions, including pledging to halt reclamation, new construction and militarisation of disputed islands in the South China Sea”.
Tricycle
Definition:
(n.) A three-wheeled velocipede. See Illust. under Velocipede. Cf. Bicycle.
Example Sentences:
(1) Accidentally discovered nearly 40 years ago as the first true antidepressants, the MAOIs soon fell into disfavor due to concerns about toxicity and seemingly lesser efficacy compared with the newer tricyclic compounds.
(2) The results prove the efficacy of the drug in all the examined patients, along with the rapidity of effects in comparison with the tricyclic antidepressants.
(3) After application of tricyclic antidepressant a larger increase in pulmonary arterial enddiastolic pressure was observed during ergometric exercise.
(4) Tricyclic antidepressants are often associated with adverse drug reactions in the elderly, so alternatives such as MAO inhibitors, alprazolam, bupropion and psychostimulants are currently being explored in this patient population.
(5) It appears that tricyclic antidepressants act in a fashion different from opiate drugs that alter the sensory discriminative component of pain.
(6) Effects of both tricyclic and non-tricyclic drugs on the extrinsic Cotton effects of dicumarol bound to human alpha 1-acid glycoprotein (AGP) have been investigated.
(7) It is concluded that the NA potentiation by tricyclic antidepressants is not the main reason for their cardiotoxic effects.
(8) As a basis for the discussion a possible structure for the DNA complex of the phenylated neutral red is considered in which the extra phenyl ring at N-5 of the phenazinium system, protrudes into the large groove of the DNA helix while the tricyclic part of the ligand is inserted between the DNA base-pairs.
(9) Because new drugs, which are really "defibrillating" drugs, are available (bretylium tosylate, bethanidine, clofilium, tricyclic antidepressants, phenotiazine derivatives), we plan to investigate these defibrillating drugs in isolated hearts, found in suitable animals like dogs (sheep and swine are difficult to defibrillate) and in humans during routine electropharmacological studies.
(10) The MAOIs represent effective alternatives to the tricyclic antidepressants.
(11) All three antagonists are composed of a very similar tricyclic ring system linked to a 1-methyl-4-piperidylene ring.
(12) The effects of a series of tricyclic and non-tricyclic antidepressants on the transport of [3H]-serotonin into synaptosomal fractions from rat brain in vitro and in vivo are summarized.
(13) Uptake of [123I]MIBG into the heart was inhibited by the tricyclic drug, imipramine, and this agent also accelerated the rate of loss of [123I]MIBG.
(14) Awareness of these factors is necessary to insure proper therapeutic utilization of the tricyclics as well as to treat effectively their toxicity.
(15) Research on plasma levels of tricyclic antidepressants suggest new clinical strategies for adjusting dosages; neurochemical studies may provide an appropriate selection process for choosing a tricyclic antidepressant.
(16) The tricyclic psychotropic drug opipramol (Insidon) reacts in vitro with sodium nitrite in acidic solution to form products including mutagens for Salmonella typhimurium TA98 and TA100.
(17) This clinical trial of a new antidepressant, fluoxetine, shows it to be as effective as a standard tricyclic drug, imipramine.
(18) Contrary to our previous study, no significant correlation was obtained between the plasma concentrations of amitriptyline, nortriptyline or total tricyclics with Hamilton rating score at 6 weeks or percentage improvement after 6 weeks treatment.
(19) The effect of low doses of antidepressants (almost always a tricyclic) appeared to be less beneficial than either higher doses or clinical management without antidepressant drugs.
(20) The fractions containing congeners with two to four ortho chlorines and the di- and tricyclic compounds had no significant effects on tissue vitamin A contents.