(n.) The hard, calcified tissue of the skeleton of vertebrate animals, consisting very largely of calcic carbonate, calcic phosphate, and gelatine; as, blood and bone.
(n.) One of the pieces or parts of an animal skeleton; as, a rib or a thigh bone; a bone of the arm or leg; also, any fragment of bony substance. (pl.) The frame or skeleton of the body.
(n.) Anything made of bone, as a bobbin for weaving bone lace.
(n.) Two or four pieces of bone held between the fingers and struck together to make a kind of music.
(n.) Dice.
(n.) Whalebone; hence, a piece of whalebone or of steel for a corset.
(n.) Fig.: The framework of anything.
(v. t.) To withdraw bones from the flesh of, as in cookery.
(v. t.) To put whalebone into; as, to bone stays.
(v. t.) To fertilize with bone.
(v. t.) To steal; to take possession of.
(v. t.) To sight along an object or set of objects, to see if it or they be level or in line, as in carpentry, masonry, and surveying.
Example Sentences:
(1) It is concluded that during exposure to simulated microgravity early signs of osteoporosis occur in the tibial spongiosa and that changes in the spongy matter of tubular bones and vertebrae are similar and systemic.
(2) In conclusion, the efficacy of free tissue transfer in the treatment of osteomyelitis is geared mainly at enabling the surgeon to perform a wide radical debridement of infected and nonviable soft tissue and bone.
(3) This bone could not be degraded by human monocytes in vitro as well as control bone (only 54% of control; P less than 0.003).
(4) It is suggested that the Japanese may have lower trabecular bone mineral density than Caucasians but may also have a lower threshold for fracture of the vertebrae.
(5) Osteoporosis is characterized by a reduction in bone density.
(6) The half-life of 45Ca in the various calcium fractions of both types of bone was 72 hours in both the control and malnourished groups except the calcium complex portion of the long bone of the control group, which was about 100 hours.
(7) We have addressed the effect of late intensification with autologous bone marrow transplantation on SCLC through a randomized clinical trial.
(8) Our results indicate that increasing the delay for more than 8 days following irradiation and TCD syngeneic BMT leads to a rapid loss of the ability to achieve alloengraftment by non-TCD allogeneic bone marrow.
(9) Decreased MU stops additions of bone by modeling and increases removal of bone next to marrow by remodeling.
(10) Pokeweed mitogen-stimulated rat spleen cells were identified as a reliable source of rat burst-promoting activity (PBA), which permitted development of a reproducible assay for rat bone marrow erythroid burst-forming units (BFU-E).
(11) The fibrous matrix and cartilage formed within the nonunion site transformed to osteoid and bone with increased vascularity.
(12) Periosteal chondroma is an uncommon benign cartilagenous lesion, and its importance lies primarily in its characteristic radiographic and pathologic appearance which should be of assistance in the differential diagnosis of eccentric lesions of bones.
(13) The compressive strength of bone is proportional to the square of the apparent density and to the strain rate raised to the 0.06 power.
(14) Furthermore echography revealed a collateral subperiosteal edema and a moderate thickening of extraocular muscles and bone periostitis, a massive swelling of muscles and bone defects in subperiosteal abscesses as well as encapsulated abscesses of the orbit and a concomitant retrobulbar neuritis in orbital cellulitis.
(15) Survival was independent of the type of clinical presentation and protocol employed but was correlated with the stage (P less than 0.0005), symptoms (P less than 0.025), bulky disease (P less than 0.025) and bone marrow involvement (P less than 0.025).
(16) There was however no difference in the cross-sectional studies and no significant deleterious effect detected of tobacco use on forearm bone mineral content.
(17) During the digestion of these radiolabeled bacteria, murine bone marrow macrophages produced low-molecular-weight substances that coeluted chromatographically with the radioactive cell wall marker.
(18) According to the finite element analysis, the design bases of fixed restorations applied in the teeth accompanied with the absorption of the alveolar bone were preferred.
(19) At consolidation, the distraction area was composed of lamellar trabecular and partly woven bone.
(20) Periodontal disease activity is defined clinically by progressive loss of probing attachment and radiographically by progressive loss of alveolar bone.
Osteoclast
Definition:
(n.) A myeloplax.
(n.) An instrument for performing osteoclasis.
Example Sentences:
(1) A novel staining procedure for enumerating osteoclasts on neonatal mouse calvaria with the vital fluorescent dye acridine orange is described.
(2) Light microscopic autoradiography after labeling of the cultures with tritiated thymidine showed that both RA and 1,25-(OH)2D3 induced osteoclast differentiation from proliferating and postmitotic precursors.
(3) We have previously shown that multinucleated cells (MNC) with many features of the osteoclast phenotype form in long term human marrow cultures.
(4) Osteoclasts dissolve bone mineral by the vectorial secretion of hydrogen ion at their osseous attachment site.
(5) Superoxide dismutase (SOD) inhibited the accumulation of formazan by the isolated osteoclasts.
(6) Addition of extracellular Ca2+ (5 mM CaCl2), a potent osteoclast inhibitor, increased [Ca2+]i in all osteoclasts, but 10(-6) M salmon calcitonin (sCT) did so only in a subpopulation of osteoclasts.
(7) Osteoclasts were isolated from the long bones of neonatal rabbits and cultured on devitalized bovine bone slices for 8, 24, 48 and 72 h with and without prostaglandin E2 (PGE2) (10(-6) M).
(8) Marrow macrophages, at various stages of in vitro maturation, also possess lysozyme mRNA but in amounts approximately two to four times lower than osteoclasts.
(9) The use of diphosphonates (bisphosphonates), a group of potent osteoclast inhibitors, is discussed in some detail.
(10) Dimethylamiloride (100 microM) inhibited bone resorption by 80% and 65% when added at t = 0 or 1 hr after osteoclast adherence, but was without effect when added at t = 3 or 6 hr.
(11) These results provide strong evidence for the osteoclastic nature of the giant cells in this variant of the MFH.
(12) Since the osteoclast plays an important role in the resorption and remodeling of bone in these middle ear diseases, the source, physiology, and local control of these cells are of prime importance in investigating the pathophysiology of these diseases.
(13) The effects of interleukin-1 did not appear to be related to osteoclast precursor proliferation, since hydroxyurea (which inhibits DNA synthesis in these cultures) had no effect on the response of calvaria calavaria increases osteoclast to interleukin-1.
(14) These results indicate that CT activates PKC in osteoclasts and that this activation, like the activation of cAMP-dependent protein kinase, leads to an inhibition of bone resorption.
(15) Quantitative time-lapse videomicroscopy showed that the CT-induced retraction of osteoclasts also involved activation of the PKC pathway and could therefore be induced by phorbol esters.
(16) Thus, the resorption-antagonizing capacities of EHDP, Cl2MDP and APD reflect metabolic inhibition, with selectivity for the osteoclast resulting from high affinity binding to bone mineral.
(17) NBT staining was detected only in osteoclasts in cultures of resorbing bones.
(18) Band 5 represents the only tartrate-resistant form and is present in bone osteoclasts and in human alveolar macrophages (AMs).
(19) These results suggest that osteoclast resorbs bone by secreting protons through vacuolar H(+)-ATPase.
(20) Hypercalcemia in this model is mediated in part by the effects of PTH-rP to increase osteoclastic bone resorption.