(v. t.) To annoy; to trouble; to worry; to perplex. See Pother.
(v. i.) To feel care or anxiety; to make or take trouble; to be troublesome.
(n.) One who, or that which, bothers; state of perplexity or annoyance; embarrassment; worry; disturbance; petty trouble; as, to be in a bother.
Example Sentences:
(1) Why bother to put the investigators, prosecutors, judge, jury and me through this if one person can set justice aside, with the swipe of a pen.
(2) Unless you are part of some Unite-esque scheme to join up as part of a grand revolutionary plan, why would you bother shelling out for a membership card?
(3) Dinner is the usual “international” menu that few will bother with given the wealth of choice nearby.
(4) Despite excellent control of acute-stage emesis, some patients are still bothered by delayed emesis occurring more than 24 hours after cisplatin administration.
(5) Given this bipartisan strategy to minimise commitments, there is little wonder that voter turnout also reached a historical low, with less than two thirds bothering to vote in the east.
(6) I do think it is set fair but I am more bothered about the eurozone.
(7) These were: urinary symptoms, degree of bother due to urinary symptoms, BPH-specific interference with activities, general psychological well-being, worries and concerns, and sexual satisfaction.
(8) Interactive guide Election countdown: the key dates up to June 7 Interactive quizzes Can you be bothered?
(9) TV's Jeremy Paxman didn't even bother hiding his disdain for the introduction of weather reports to Newsnight – "It's April.
(10) And indeed both E.ON and SSE offer these for those who bother to switch,” he added.
(11) After the first couple days like everyone was like: 'Ah, I can't be bothered.
(12) Had they bothered to inquire of a veteran from the ranks, they might have heard how exasperating it is to see the dainty long-range patriots of Labour thrashing it out with the staunch gutter jingoists of the Conservative party – and barely a non-commissioned vet among them.
(13) I have been noticing, with sadness, that politicians do not even bother invoking the American Dream anymore.
(14) "No one ever bothered him at the suppers," former pastor Bob Moyer of Hartland told the paper.
(15) Refusing to play in the Seven Kingdoms league, the all black kit helps the team in matches against Wildling FC, who never bother to wear the same colours.
(16) No one else need bother to paint them as a ramshackle and rancorous rabble marooned in the past and without a plausible account of the future.
(17) With the coming of the meritocracy, the now leaderless masses were partially disfranchised; as time has gone by, more and more of them have been disengaged, and disaffected to the extent of not even bothering to vote.
(18) A cursory web search would have helped but fewer of us bother when the news is relatively inconsequential.
(19) What bothers me is that a club would contact the manager of a national team without first notifying the Federation.
(20) Arsenal responded in the only way they know, with Ramsey, Mesut Özil, Jack Wilshere and Oxlade-Chamberlain all involved in intricate passing patterns on the edge of the area, though there was no end product to bother Tim Howard apart from another long shot from Oxlade-Chamberlain that drifted wide.
Pucker
Definition:
(v. t. & i.) To gather into small folds or wrinkles; to contract into ridges and furrows; to corrugate; -- often with up; as, to pucker up the mouth.
(n.) A fold; a wrinkle; a collection of folds.
(n.) A state of perplexity or anxiety; confusion; bother; agitation.
Example Sentences:
(1) As in the protein sample, a tendency for the cis-proline residues to have the DOWN pucker was observed, but the effect was less pronounced.
(2) The ultrastructural findings of the macular pucker removed by vitreoretinal surgery are demonstrated.
(3) Sugar puckers and proton distances are very sensitive criteria to monitor molecular dynamics.
(4) Intranucleotide proton-proton distances combined with the knowledge of sugar puckers have been used to fix the glycosidic bond torsion angle (chi).
(5) High proliferative activities were found in 4 of 5 PVR membranes, in 9 of 14 PDR membranes, in 6 of 11 recurrent membranes after intraocular silicone oil tamponade, and in 2 of 6 macular pucker membranes.
(6) No "flips" to the opposite puckering for this ring were found in the simulations starting from the global minimum, although such a transition was observed for a trajectory initiated with one of the higher local minimum energy conformations.
(7) Thus, flexibility in psi as well as in omega and omega, and in the sugar pucker is indicated.
(8) These facts suggest that astrocytes play an important role in preretinal membrane formation in macular pucker.
(9) The free duplex adopts a regular right-handed B-type conformation in which all glycosidic bond angles are anti and all sugar puckers lie in the C2'-endo range.
(10) All cases occurred in eyes with existing retinal holes or tears, including eight cases of macular pucker after previous retinal detachment.
(11) The conformations of the terminal residues of helix I, which corresponds to bases (-1)-11 and 108-120 of native 5S RNA, are less well-determined, and their sugar puckers are intermediate between C2' and C3'-endo, on average.
(12) Different ester substituents affect 1,4-dihydropyridine ring puckering to a small extent in most cases.
(13) Scalar couplings from correlated experiments and interproton distances from NOESY experiments at short mixing times have been used to determine glycosidic angles, sugar puckers, and other conformational features.
(14) There appeared to be a possibility that this muscular thickening might give rise to the rectosigmoidal mucosal puckering often seen through a sigmoidoscope.
(15) Intranucleotide NOEs from the sugar protons H1', H2', and H3' to the base protons were used to determine the conformation of each nucleotide (puckers and glycosidic torsion angles).
(16) The most flexible conformational angles in the structure are the glycosidic angle and the sugar pucker.
(17) Of these, 89% of the cis-proline residues exhibit the DOWN pucker, while the trans-proline residues, on average, are about evenly distributed between the two forms.
(18) The folding of the polynucleotide chain is accomplished either solely by rotations around the P-O bonds or in concert with rotations around the nucleotide C4'-C5' bond with or without changes in the sugar ring pucker.
(19) Postoperative proliferative vitreoretinopathy occurred in six eyes (10%) and macular pucker in two (3%).
(20) The glycosidic torsional angle, chiCN = -28.4 degrees, is in the anti region; the sugar pucker is C(2')exo-C(3')endo in a nearly pure 32H twist; and the conformation of C(4')-C(5') is gauche-gauche.