(n.) The external or limiting line, either real or imaginary, of any object or space; that which limits or restrains, or within which something is limited or restrained; limit; confine; extent; boundary.
(v. t.) To limit; to terminate; to fix the furthest point of extension of; -- said of natural or of moral objects; to lie along, or form, a boundary of; to inclose; to circumscribe; to restrain; to confine.
(v. t.) To name the boundaries of; as, to bound France.
(v. i.) To move with a sudden spring or leap, or with a succession of springs or leaps; as the beast bounded from his den; the herd bounded across the plain.
(v. i.) To rebound, as an elastic ball.
(v. t.) To make to bound or leap; as, to bound a horse.
(v. t.) To cause to rebound; to throw so that it will rebound; as, to bound a ball on the floor.
(n.) A leap; an elastic spring; a jump.
(n.) Rebound; as, the bound of a ball.
(n.) Spring from one foot to the other.
() imp. & p. p. of Bind.
(p. p. & a.) Restrained by a hand, rope, chain, fetters, or the like.
(p. p. & a.) Inclosed in a binding or cover; as, a bound volume.
(p. p. & a.) Under legal or moral restraint or obligation.
(p. p. & a.) Constrained or compelled; destined; certain; -- followed by the infinitive; as, he is bound to succeed; he is bound to fail.
(p. p. & a.) Resolved; as, I am bound to do it.
(p. p. & a.) Constipated; costive.
(v.) Ready or intending to go; on the way toward; going; -- with to or for, or with an adverb of motion; as, a ship is bound to Cadiz, or for Cadiz.
Example Sentences:
(1) These studies led to the following conclusions: (a) all the prominent NHP which remain bound to DNA are also present in somewhat similar proportions in the saline-EDTA, Tris, and 0.35 M NaCl washes of nuclei; (b) a protein comigrating with actin is prominent in the first saline-EDTA wash of nuclei, but present as only a minor band in the subsequent washes and on washed chromatin; (c) the presence of nuclear matrix proteins in all the nuclear washes and cytosol indicates that these proteins are distributed throughout the cell; (d) a histone-binding protein (J2) analogous to the HMG1 protein of K. V. Shooter, G.H.
(2) The results demonstrated that K2PtCl4 was bound to a greater degree than CDDP in this system with 3-5 and 1-2 platinum atoms respectively, bound per transferrin molecule.
(3) Extensive studies during recent years have shown that the interaction between hormone and membrane-bound receptor can affect the receptor characteristics in at least two ways.
(4) These results are discussed in relation to the possible existence of enzyme-bound intermediates of nitrogen fixation.
(5) In the second approach, attachment sites of DTPA groups were directed away from the active region of the molecule by having fragment E1,2 bound in complex, with its active sites protected during the derivatization.
(6) For similar inotropic responses, normo- and hyperkalaemic dogs had similar levels of (Na+, K+)-ATPase inhibition and microsomal-bound digoxin.
(7) The penicillin-resistant Enterococcus hirae R40 has a typical profile of membrane-bound penicillin-binding proteins (PBPs) except that the 71 kDa PBP5 of low penicillin affinity represents about 50% of all the PBPs present.
(8) Electron spin resonance studies indicate the formation of two vanadyl complexes that are 1:1 in vanadyl and deferoxamine, but have two or three bound hydroxamate groups.
(9) Treatment of the bound F1-ATPase with 4-chloro-7-nitrobenzofurazan prevented complete release of the enzyme by ATP.
(10) Only estrogenic hormones are bound with high affinity.
(11) Plasma for beta-endorphin assay was preincubated with sepharose-bound anti-beta-lipotropin to remove beta-lipotropin that cross-reacted with the beta-endorphin RIA.
(12) I think part of it is you can either go places where that's bound to happen.
(13) Freshly isolated sarcoplasmic reticulum vesicles contain 0.05 mol of tightly bound ADP and 0.03 mol of tightly bound ATP per mol of Ca2+, Mg2+-ATPase (ATP phosphohydrolase, EC 3.6.1.3).
(14) Agarose-albumin beads may be useful for removing protein-bound substances from the blood of patients with liver failure, intoxication with protein-bound drugs, or specific metabolic deficits.
(15) Immunoabsorption studies showed that these four antibodies bound to the same molecule as OKT9, an antibody to the transferrin receptor.
(16) We investigated this suppression quantitatively, using a chemical assay for cell-bound and dissolved capsular polysaccharide.
(17) Only IgG2a and IgG2b myeloma proteins bound readily to IC-21 Fc-receptors, the former in nonaggregated as well as aggregated form, the latter only as aggregated complexes.
(18) When antibodies were bound to cell-surface DPP IV at 4 degrees C, the immune complex remained stable for more than 1 h after rewarming to 37 degrees C, despite ongoing metabolic and membrane transport processes.
(19) Plasmids containing the inverted repeat alone bound ER, though less efficiently than did plasmids containing the entire sequence.
(20) Inhibition of fast axonal transport by an antibody specific for kinesin provides direct evidence that kinesin is involved in the translocation of membrane-bounded organelles in axons.
Demonstration
Definition:
(n.) The act of demonstrating; an exhibition; proof; especially, proof beyond the possibility of doubt; indubitable evidence, to the senses or reason.
(n.) An expression, as of the feelings, by outward signs; a manifestation; a show.
(n.) The exhibition and explanation of a dissection or other anatomical preparation.
(n.) (Mil.) a decisive exhibition of force, or a movement indicating an attack.
(n.) The act of proving by the syllogistic process, or the proof itself.
(n.) A course of reasoning showing that a certain result is a necessary consequence of assumed premises; -- these premises being definitions, axioms, and previously established propositions.
Example Sentences:
(1) The Na+ ionophore, gramicidin, had a small but significant inhibitory effect on Na(+)-dependent KG uptake, demonstrating that KG uptake was not the result of an intravesicular positive Na+ diffusion potential.
(2) Patient plasma samples demonstrated evidence of marked complement activation, with 3-fold elevations of C3a desArg concentrations by the 8th day of therapy.
(3) The influence of the various concepts for the induction of lateral structure formation in lipid membranes on integral functional units like ionophores is demonstrated by analysing the single channel current fluctuations of gramicidin in bimolecular lipid membranes.
(4) Of the patients 73% demonstrated clinically normal sensibility test results within 23 days after operation.
(5) Lucy and Ed will combine coverage of hard and breaking news with a commitment to investigative journalism, which their track record so clearly demonstrates”.
(6) These immunocytochemical studies clearly demonstrated that cells encountered within the fibrous intimal thickening in the vein graft were inevitably smooth muscle cell in origin.
(7) Competition with the labelled 10B12 MAb for binding to the purified antigen was demonstrated in sera of tumor-bearing and immune rats.
(8) Using monoclonal antibodies directed against the plasma membrane of Madin-Darby canine kidney (MDCK) cells, we demonstrated previously that a glycoprotein with an Mr = 23,000 (gp23) had a non-polarized cell surface distribution and was observed on both the apical and basolateral membranes (Ojakian, G. K., Romain, R. E., and Herz, R. E. (1987) Am.
(9) These results demonstrate that increased availability of galactose, a high-affinity substrate for the enzyme, leads to increased aldose reductase messenger RNA, which suggests a role for aldose reductase in sugar metabolism in the lens.
(10) Intravesical BCG is clearly superior to oral BCG, and controlled studies have demonstrated that percutaneous administration is not necessary.
(11) We have previously shown that serotonin is present in secretory granules of frog adrenochromaffin cells; concurrently, we have demonstrated that serotonin is a potent stimulator of corticosterone and aldosterone secretion by adrenocortical cells.
(12) Microionophoretically applied excitatory amino acids induced firing of extracellularly recorded single units in a tissue slice preparation of the mouse cochlear nucleus, and the similarly applied antagonist 2-amino-5-phosphonovalerate (2APV) was demonstrated to be a selective N-methyl-D-aspartate (NMDA) receptor antagonist.
(13) The results demonstrated that K2PtCl4 was bound to a greater degree than CDDP in this system with 3-5 and 1-2 platinum atoms respectively, bound per transferrin molecule.
(14) These studies, in addition to demonstrating that the placenta contains TRH deamidase activity, suggest that losses of fetal TRH through the placenta are not large.
(15) Light microscopic studies of pancreata from mice sacrificed at this time demonstrated insulitis and beta cell necrosis.
(16) Western blot analysis of these mitochondria using an antibody against carnitine palmitoyltransferase II purified from beef heart demonstrates a 68-kDa protein, which under ischemic conditions apparently is decreased by 2 kDa.
(17) Acquired drug resistance to INH, RMP, and EMB can be demonstrated in M. kansasii, and SMX in combination with other agents chosen on the basis of MIC determinations are effective in the treatment of disease caused by RMP-resistant M. kansasii.
(18) In 1 of the 3, anterior capsular detachment was also demonstrated radiographically and confirmed surgically.
(19) This result demonstrates that branching enzyme belongs to a family of the amylolytic enzymes.
(20) Histological studies of nerves 2 years following irradiation demonstrated loss of axons and myelin, with a corresponding increase in endoneurial, perineurial, and epineurial connective tissue.