(1) This peptide is equivalent to the cDNA-derived sequence 468-476 of Ca2+-ATPase [Brandl et al.
(2) Altogether, nine inhibitory antibodies were produced: six of these inhibitory antibodies mapped to the same spatial region, although they appear to bind to two distinct epitopes located within the hinge region and the nucleotide-binding domains of current structural models; one antibody bound to an epitope located within the phosphorylation domain and the stalk-transmembranous region designated M4S4 by Brandl, Green, Korczak & MacLennan [(1986) Cell 44, 597-607].
(3) In contrast, application of 100.0 MPa to the calcium-transport enzyme at room temperature accelerates subsequent tryptic cleavage at the T2 but not at the T1 cleavage site [C. J. Brandl et al.
(4) This additional exon shifts the exon encoding the neonatal carboxyl-terminal sequence, -Asp-Pro-Glu-Asp-Glu-Arg-Arg-Lys (Brandl, C. J., Green, N. M., Korczak, B., and MacLennan, D. H. (1986) Cell 44, 597-607) into a nontranslated region and results in the expression of an adult isoform with a carboxyl-terminal -Gly.
(5) The cDNA (termed FCa) comprised 3,239 base pairs, including an open reading frame encoding 994 amino acids which showed the highest degree of homology with the adult rabbit fast-twitch Ca2+-ATPase isoform (C. J. Brandl, S. de Leon, D. R. Martin, and D. H. MacLennan, J. Biol.
(6) The N-terminal sequence of this peptide, (Trp)-Phe-Met-Tyr-Ala, forms the basis for an oligodeoxynucleotide probe, the use of which to identify cDNA corresponding to the ATPase is described elsewhere [MacLennan, Brandl, Korczak & Green (1985) Nature (London) 316, 696-700].
(7) These results question an earlier proposition that Ca2(+)-binding is located to the "stalk" region of Ca2(+)-ATPase (Brandl, C. J., Green, N. M., Korczak, B., and MacLennan, D. H.) (1986) Cell 44, 597-607) but are in agreement with recent data obtained by oligonucleotide-directed mutagenesis of Ca2(+)-ATPase (Clarke, D. M., Loo, T. W., Inesi, G., and MacLennan, D. H. (1989) Nature 339, 476-478).
(8) The observed calcium fluxes are attributed to a slow channel formed by ATPase transmembrane helices (MacLennan, D. H., Brandl, C. J., Korczak, B., and Green, N. M. (1985) Nature 316, 686-700) and are capable of long range interaction with the catalytic site.
(9) In a previous study (Brandl, C. J., de Leon, S., Martin, D. R., and MacLennan, D. H. (1987) J. Biol.
(10) Domain I (Tm = 50 degrees C) consists of the nucleotide binding region and most likely the phosphorylation and transduction regions [MacLennan, D. H., Brandl, C. J., Korczak, B., & Green, N. M. (1985) Nature 316, 696-700].
(11) Both of these sequences were found in the amino acid sequence of Ca2+-transporting ATPase (Brandl et al.
(12) Pointing out that a vaccine is not expected in the short term, PAHO's Dr. David Brandling-Bennet stressed that the fight against AIDS depends on disseminating information.
(13) These results are consistent with, and support, our model for folding of the Ca2(+)-ATPase (Brandl, C. J., Korczak, B., Green, N. M., and MacLennan, D. H. (1986) Cell 44, 597-607) in which residues 657-672 were proposed to form part of the cytoplasmic nucleotide binding domain, while residues 870-890 were proposed to form a luminal loop between proposed transmembrane sequences M7 and M8.
Worm
Definition:
(n.) A creeping or a crawling animal of any kind or size, as a serpent, caterpillar, snail, or the like.
(n.) Any small creeping animal or reptile, either entirely without feet, or with very short ones, including a great variety of animals; as, an earthworm; the blindworm.
(n.) Any helminth; an entozoon.
(n.) Any annelid.
(n.) An insect larva.
(n.) Same as Vermes.
(n.) An internal tormentor; something that gnaws or afflicts one's mind with remorse.
(n.) A being debased and despised.
(n.) Anything spiral, vermiculated, or resembling a worm
(n.) The thread of a screw.
(n.) A spiral instrument or screw, often like a double corkscrew, used for drawing balls from firearms.
(n.) A certain muscular band in the tongue of some animals, as the dog; the lytta. See Lytta.
(n.) The condensing tube of a still, often curved and wound to economize space. See Illust. of Still.
(n.) A short revolving screw, the threads of which drive, or are driven by, a worm wheel by gearing into its teeth or cogs. See Illust. of Worm gearing, below.
(v. i.) To work slowly, gradually, and secretly.
(v. t.) To effect, remove, drive, draw, or the like, by slow and secret means; -- often followed by out.
(v. t.) To clean by means of a worm; to draw a wad or cartridge from, as a firearm. See Worm, n. 5 (b).
(n.) To cut the worm, or lytta, from under the tongue of, as a dog, for the purpose of checking a disposition to gnaw. The operation was formerly supposed to guard against canine madness.
(n.) To wind rope, yarn, or other material, spirally round, between the strands of, as a cable; to wind with spun yarn, as a small rope.
Example Sentences:
(1) Other filarial worms which are known to occur in the RSA are discussed.
(2) The drugs were moderately potent inhibitors of both E. electricus and C. elegans acetylcholinesterase but at concentrations too high to account for their abilities to contract cut worms.
(3) The sectioned worm tissues from each developmental stage were embedded in Lowicryl HM 20 medium, stained with infected serum IgG and protein A gold complex (particle size: 12 nm) and observed by electron microscopy.
(4) glp-4(bn2ts) mutant worms raised at the restrictive temperature contain approximately 12 germ nuclei, in contrast to the 700-1000 present in wild-type adults.
(5) Fluorescein isothiocyanate (FITC)-ricin exhibited binding to schistosomula and adult worms, but not to cercariae or to freshly transformed schistosomula.
(6) Sera from S. mansoni-infected patients with a high specificity for the diagnostic S. mansoni-antigen cross-reacted with a corresponding component also in S. japonicum worms.
(7) To understand mechanisms involved in sex-specific gene expression in Schistosoma mansoni, a cDNA (fs800) was isolated that hybridized to an 800 nucleotide mRNA present in high levels only in mature female worms.
(8) Three freeze-thaw cycles released a large proportion (50% to 60%) of the TCA-precipitable radioactivity from the worms.
(9) Antigen inhibition studies showed low and high levels of cross-reactivity with anti-worm and anti-egg antibodies, respectively, derived from both Chinese and Philippine patients.
(10) Only eosinophils adhered to 2 h newborn worms and only macrophages to 20 h ones.
(11) Worms had invaded the bile duct in 51 patients, the pancreatic duct in four and both ducts in four.
(12) The number of ovarian balls rises to about 6300 per worm, with the maximum being attained more rapidly in unfertilized than in fertilized females.
(13) Or perhaps the "mad cow"-fuelled beef war in the late 1990s, when France maintained its ban on British beef for three long years after the rest of the EU had lifted it, prompting the Sun to publish a special edition in French portraying then president Jacques Chirac as a worm.
(14) Three bulls selected for high faecal worm egg counts and three bulls selected for low faecal worm egg counts were mated to Africander-Hereford cross cows.
(15) Among 30 villagers who were treated, 4 (13.3%) passed this species with an average of 2.5 worms per infection.
(16) Successful tests were carried out on 84 farms and 68% of these had resistant worms present.
(17) A higher retention rate of intestinal adult worms was observed in hydrocortisone-treated mice.
(18) No evidence was obtained for the involvement of monoamine oxidases in the metabolism of 5-HT in these filarial worms.
(19) Radiocarbons from glucosamine and leucine were incorporated into tissue glycogen of female worms much less than glucose.
(20) The heads were examined for adult and larval meningeal worms (Parelaphostrongylus tenuis) by physical examination of the brain surfaces, and the Baermann technique, respectively, and for ear mites by examination of ear scrapings.