(n.) A coarse garment or cloak; also, coarse clothing, in general.
(n.) A coarse kind of apron for keeping the clothes clean; a bib.
(n.) A child; an offspring; -- formerly used in a good sense, but now usually in a contemptuous sense.
(n.) The young of an animal.
(n.) A thin bed of coal mixed with pyrites or carbonate of lime.
Example Sentences:
(1) a) synovial bursa ( schleimbeutel ) b) sneeze guard ( Spukschutz ) c) snotty-nosed brat – literally snot spoon ( rotzloeffel ) d) grumpy bastard – literally lump of vomit ( kotzbrocken ) 4,000 Jet-setters complain of a) Jetleg b) Jetleck c) Jetlag d) Jetlack 8,000 Who, if a contestant on Who Wants To Be A Millionaire, would definitely not call the Joker?
(2) Founded in 1982, Twenty Twenty is the company behind factual programmes such as The Choir, That'll Teach 'Em', Bad Lads Army, Brat Camp and current BBC2 show Grandad's Back in Business.
(3) The hack by the group Guardians of Peace revealed email conversations between Sony executives and actors, discussing the likes of Pitt’s wife Angelina Jolie, who was described as a “minimally talented spoiled brat” by producer Scott Rudin.
(4) After the jet-black high school satire Heathers pulled the rug out from under John Hughes and his oversharing Brat Pack, in 1989, American adolescents were left with few offerings, most of them wistful odes to another age – either stylistically, as with the overblown, pirate-radio-themed Christian Slater vehicle Pump Up the Volume; or quite literally, in the case of Richard Linklater’s nostalgia-fuelled 70s pastiche, Dazed and Confused.
(5) It’s not only the very young who can be immature comical brats when the music doesn’t go their way.
(6) After Obama's re-election, Nugent said on Twitter: "Pimps whores & welfare brats & their soulless supporters have a president to destroy America."
(7) By the time the dust finally settled in Virginia's primary election earthquake just 7,212 votes separated the House majority leader, Eric Cantor, from his Tea Party nemesis, David Brat.
(8) In the course of their exchanges, Rudin called Angelina Jolie “a minimally talented spoiled brat” with a “rampaging ego”.
(9) Some felt it was the most likable she had ever been while others believed it to be evidence that she was nothing but a spoilt brat.
(10) The shadow defence secretary, Jim Murphy, said on Twitter : "Some of these Tories are foul-mouthed spoilt little brats and now one caught by the Sun."
(11) Rudin described the star as “a minimally talented spoiled brat” in possession of a “rampaging ego”.
(12) With strong support from business groups – which back Republlican leaders on immigration reform – Cantor used his substantial funding advantage to run aggressive attack ads against the relatively unknown Brat.
(13) I just came up short and the voters elected another candidate.” But the Republican heavyweight, once seen as a natural successor to speaker John Boehner, insisted he had not neglected his constituents as Brat has claimed.
(14) "This is a miracle from God," said a triumphant Brat.
(15) But his defeat by Brat, a relatively unknown economics professor, will send shockwaves through a party leadership that thought it had survived the 2014 primary election season with relatively limited damage from the Tea Party.
(16) It sold nearly 3m copies and established Franzen as one of the leading literary voices of his generation, but, thanks to his perceived snub to Winfrey, it also established his reputation as, variously, an "ego-blinded snob" (Boston Globe), a "pompous prick" (Newsweek) and a "spoiled, whiny little brat" (Chicago Tribune).
(17) Cantor’s primary opponent in Virginia’s seventh congressional district, a professor named David Brat, was not backed by any of the national Tea Party organisations.
(18) In one of Sony Pictures’ many hacked emails , producer Scott Rudin called Jolie, an Oscar winner and recipient of the Jean Hersholt Humanitarian Award , “a minimally talented spoiled brat”.
(19) She's dragged herself from unloved brat to brass to millionaire (via some dead husbands, but let's be real, a good few Guardian readers would do the same if a plush three-bed Victorian terrace was their prize).
(20) But although turnout in the open primary was 28 per cent higher than normal, Cantor’s total vote dropped from 37,698 in 2012 to 28,898 and Brat did best in heavily Republican precincts.
Imp
Definition:
(n.) A shoot; a scion; a bud; a slip; a graft.
(n.) An offspring; progeny; child; scion.
(n.) A young or inferior devil; a little, malignant spirit; a puny demon; a contemptible evil worker.
(n.) Something added to, or united with, another, to lengthen it out or repair it, -- as, an addition to a beehive; a feather inserted in a broken wing of a bird; a length of twisted hair in a fishing line.
(n.) To graft; to insert as a scion.
(n.) To graft with new feathers, as a wing; to splice a broken feather. Hence, Fig.: To repair; to extend; to increase; to strengthen to equip.
Example Sentences:
(1) Intramembrane particles (IMP) were quantitatively assessed in the perikaryal plasma membranes of infundibular neurons.
(2) The inhibition by TAD of IMP DH activity in ovarian carcinomas (N = 4) was 81%.
(3) Incubation of I diaphragms with isoproterenol did not significantly increase the concentrations of AMP, IMP or inorganic phosphate, activators of phosphorylase beta activity, nor was there a decrease in ATP and glucose 6-phosphate content, allosteric inhibitors of phosphorylase beta activity.
(4) Second, interconversion of adenine nucleotides to guanine nucleotides, is curtailed by the inhibition of IMP dehydrogenase by these same IMP analogues.
(5) Under optimal reaction conditions, HhaI and RsaI cleaved the DMTS-std duplex to 76-77% completion and the DMTS-imp duplex to 96-99% completion.
(6) The incorporation of inosine or hypoxanthine into the IMP and ITP has been proved.
(7) At all times, a tight inverse correlation exists between ATP and IMP concentrations.
(8) It was concluded that the IMP content of human skeletal muscle is very low at rest and after low-intensity exercise, but increases after moderate and high-intensity exercise.
(9) The synthetic "C" nucleoside, tiazofurin (2-beta-D-ribofuranosylthiazole-4-carboxamide), its selenium analogue selenazofurin, and the related inhibitor of inosine 5'-phosphate (IMP) dehydrogenase, mycophenolic acid, are effective inducers of the terminal differentiation of HL-60 promyelocytic leukemia cells.
(10) After 60 min recovery, exercise was performed for 8-10 min each at 20, 30, 40 and 50 W. Measurements of pulmonary oxygen uptake, heart rate, blood pressure, leg blood flow, and femoral arterial-venous differences of oxygen content and lactate were performed as well as determination of ATP, creatine phosphate (CP) inosine monophosphate (IMP) and lactate concentrations on biopsy material from the quadriceps muscle before and immediately after the intense exercise, and at 3, 10 and 60 min into recovery.
(11) Virazole 5'-phosphate was subsequently found to be a potent competitive inhibitor of inosine 5'-phosphate dehydrogenase (IMP:NAD(+) oxidoreductase, EC 1.2.1.14) isolated from Escherichia coli (K(m) = 1.8 x 10(-5) M) with a K(i) of 2.7 x 10(-7) M. Guanosine 5'-phosphate (GMP) was a competitive inhibitor of this enzyme with a K(i) of 7.7 x 10(-5) M. Virazole 5'-phosphate was similarly active against IMP dehydrogenase isolated from Ehrlich ascites tumor cells, with a K(i) of 2.5 x 10(-7) M. The K(m) for this enzyme was 1.8 x 10(-5) M, and the K(i) for GMP was 2.2 x 10(-4) M. These results suggest that the antiviral activity of Virazole might be due to the inhibition of GMP biosynthesis in the infected cell at the step involving the conversion of IMP to xanthosine 5'-phosphate.
(12) Initial rate kinetic studies demonstrate the ppGpp inhibition is competitive with respect to GTP and noncompetitive with respect to L-aspartate and IMP.
(13) Uptake of IMP was calculated from the arteriovenous difference of 14C-IMP across the lung and lung effluents and homogenates were analyzed for the presence of metabolites of IMP.
(14) During continuous isometric exercise with constant stimulation time, the amount of IMP was linearly and inversely related to the age of the animals; a higher IMP concentration was found in intermittent isometric and dynamic exercise.
(15) We evaluated the effect of high partial pressures of O2 on pulmonary uptake and metabolism of IMP.
(16) Thus, 123I-IMP and 99mTc-HM-PAO SPECTs seemed to be a useful tool in the diagnosis, deciding of whether the treatment was suspended or continued, and clarifying the pathophysiology in HSE.
(17) It was considered that the analysis of the lung release of 123I-IMP forms a new lung dysfunction index.
(18) The increased activity in cancer cells of inosine 5'-monophosphate dehydrogenase (IMP DH, EC 1.1.1.205), the rate-limiting enzyme of de novo GTP biosynthesis, was suggested as a sensitive target for chemotherapy.
(19) To determine the biochemical mechanisms of cytotoxicity of these drugs, assay procedures have been developed for measurement of the levels of intermediates proximal to IMP in the pathway for de novo purine biosynthesis in mouse L1210 leukemia cells.
(20) Our review indicates that 123I-IMP SPECT may have an important future role in the early diagnosis and management of patients with acute infarctive stroke and AD.