(v. t.) To strain apart; to sever by fracture; to divide with violence; as, to break a rope or chain; to break a seal; to break an axle; to break rocks or coal; to break a lock.
(v. t.) To lay open as by breaking; to divide; as, to break a package of goods.
(v. t.) To lay open, as a purpose; to disclose, divulge, or communicate.
(v. t.) To infringe or violate, as an obligation, law, or promise.
(v. t.) To interrupt; to destroy the continuity of; to dissolve or terminate; as, to break silence; to break one's sleep; to break one's journey.
(v. t.) To destroy the completeness of; to remove a part from; as, to break a set.
(v. t.) To destroy the arrangement of; to throw into disorder; to pierce; as, the cavalry were not able to break the British squares.
(v. t.) To shatter to pieces; to reduce to fragments.
(v. t.) To exchange for other money or currency of smaller denomination; as, to break a five dollar bill.
(v. t.) To destroy the strength, firmness, or consistency of; as, to break flax.
(v. t.) To weaken or impair, as health, spirit, or mind.
(v. t.) To diminish the force of; to lessen the shock of, as a fall or blow.
(v. t.) To impart, as news or information; to broach; -- with to, and often with a modified word implying some reserve; as, to break the news gently to the widow; to break a purpose cautiously to a friend.
(v. t.) To tame; to reduce to subjection; to make tractable; to discipline; as, to break a horse to the harness or saddle.
(v. t.) To destroy the financial credit of; to make bankrupt; to ruin.
(v. t.) To destroy the official character and standing of; to cashier; to dismiss.
(v. i.) To come apart or divide into two or more pieces, usually with suddenness and violence; to part; to burst asunder.
(v. i.) To open spontaneously, or by pressure from within, as a bubble, a tumor, a seed vessel, a bag.
(v. i.) To burst forth; to make its way; to come to view; to appear; to dawn.
(v. i.) To burst forth violently, as a storm.
(v. i.) To open up; to be scattered; to be dissipated; as, the clouds are breaking.
(v. i.) To become weakened in constitution or faculties; to lose health or strength.
(v. i.) To be crushed, or overwhelmed with sorrow or grief; as, my heart is breaking.
(v. i.) To make an abrupt or sudden change; to change the gait; as, to break into a run or gallop.
(v. i.) To fail in musical quality; as, a singer's voice breaks when it is strained beyond its compass and a tone or note is not completed, but degenerates into an unmusical sound instead. Also, to change in tone, as a boy's voice at puberty.
(v. i.) To fall out; to terminate friendship.
(v. t.) An opening made by fracture or disruption.
(v. t.) An interruption of continuity; change of direction; as, a break in a wall; a break in the deck of a ship.
(v. t.) A projection or recess from the face of a building.
(v. t.) An opening or displacement in the circuit, interrupting the electrical current.
(v. t.) An interruption; a pause; as, a break in friendship; a break in the conversation.
(v. t.) An interruption in continuity in writing or printing, as where there is an omission, an unfilled line, etc.
(v. t.) The first appearing, as of light in the morning; the dawn; as, the break of day; the break of dawn.
(v. t.) A large four-wheeled carriage, having a straight body and calash top, with the driver's seat in front and the footman's behind.
(v. t.) A device for checking motion, or for measuring friction. See Brake, n. 9 & 10.
(n.) See Commutator.
Example Sentences:
(1) Lucy and Ed will combine coverage of hard and breaking news with a commitment to investigative journalism, which their track record so clearly demonstrates”.
(2) They spend about 4.3 minutes of each working hour on a smoking break, the study shows.
(3) The mechanism by which pertussis toxin (PT) breaks the unresponsiveness of delayed-type hypersensitivity (DTH) to sheep red blood cells (SRBC) was examined in B10 mice.
(4) After absorption of labeled glucose, two pools of trehalose are found in dormant spores, one of which is extractable without breaking the spores, and the other, only after the spores are disintegrated.
(5) The following possible explanations were discussed: a) the tested psychotropic drugs block prostaglandin receptors in the stomach; b) the test substances react with prostaglandin in the nutritive solution; c) the substances stimulate metabolic processes in the stomach wall that break down prostaglandin.
(6) The ability of ligand to stimulate its own synthesis and that of its receptor suggests the presence of an autocrine positive feedback loop, however we were unable to break this loop in the breast cancer cells by antibodies that blocked the interaction of TGF alpha with the EGF receptor.
(7) Neutral sucrose density sedimentation patterns indicate that neutron-induced double strand-breaks sometimes occur in clusters of more than 100 in the same phage and that the effeciency with which double strand-breaks form is about 50 times that of gamma-induced double strand-breaks.
(8) Possible explanations of the clinical gains include 1) psychological encouragement, 2) improvements of mechanical efficiency, 3) restoration of cardiovascular fitness, thus breaking a vicous circle of dyspnoea, inactivity and worsening dyspnoea, 4) strengthening of the body musculature, thus reducing the proportion of anaerobic work, 5) biochemical adaptations reducing glycolysis in the active tissues, and 6) indirect responses to such factors as group support, with advice on smoking habits, breathing patterns and bronchial hygiene.
(9) At high luminances, the temporal, but not spatial, properties of this mechanism break down in a manner which had not been studied.Low-frequency inhibitory processThis process is manifest as a decrease in sensitivity from that of the simple excitatory process.
(10) These experiments represent the first occasion that the sequence specificity of a DNA damaging agent, which causes only double-strand breaks, has been determined to the exact base-pair in intact cells.
(11) The OPL first appears as a thin, discontinuous break in the cytoblast layer that is frequently interrupted by the profiles of migrating neuro- and glioblasts.
(12) Celebrity woodlanders Tax breaks and tree-hugging already draw the wealthy and well-known to buy British forests.
(13) But we need politicians to break out of historical routines.
(14) For Burroughs, who had been publishing ground-breaking books for 20 years without much appreciable financial return, it was association with fame and the music industry, as well as the possible benefits: a wider readership, film hook-ups and more money.
(15) Once you've invested many years in a career, figuring out how to take time out and then return to a role that's comparable to the one you left (or as comparable as you want it to be) requires more than confidence and enthusiasm - employers need to actively acknowledge the benefits of such breaks and be more receptive to those seeking to return”.
(16) A dose-dependent increase in chromatid lesions, i.e., achromatic lesions, chromatid breaks, chromatid deletions and triradial or quandriradial chromosomal exchange fiqures, was found.
(17) From the stress-strain curve the following values were selected: strain, stress, and slope at 80 mmHg equivalent pressure (1 mmHg = 133.3 Pa); maximum stress, strain, and slope; and breaking stress, strain, and slope if the sample broke.
(18) Everyone worked hard, but it is fair to pick out Willian because of his work-rate, quality on the ball, participation in the first goal and quality of the second.” It had been Willian’s fizzed cross, 11 minutes before the break, which Dragovic had nodded inadvertently inside Shovkovskiy’s near post to earn the hosts their initial lead.
(19) The possibility that mammalian DNA topoisomerase II is an intracellular target which mediates drug-induced DNA breaks is supported by the following studies using 4'-(9-acridinylamino)methane-sulfon-m-anisidide (m-AMSA): (a) a single m-AMSA-dependent DNA cleavage activity copurified with calf thymus DNA topoisomerase II activity at all chromatographic steps of the enzyme purification; (b) m-AMSA-induced DNA cleavage by this purified activity resulted in the covalent attachment of protein to the 5'-ends of the DNA via a tyrosyl phosphate bond.
(20) The authorities had said they used water cannon, teargas and smoke grenades to break up the protest.
Disintegrate
Definition:
(v. t.) To separate into integrant parts; to reduce to fragments or to powder; to break up, or cause to fall to pieces, as a rock, by blows of a hammer, frost, rain, and other mechanical or atmospheric influences.
(v. i.) To decompose into integrant parts; as, chalk rapidly disintegrates.
Example Sentences:
(1) After absorption of labeled glucose, two pools of trehalose are found in dormant spores, one of which is extractable without breaking the spores, and the other, only after the spores are disintegrated.
(2) The interaction between PE and E-IgG involved the extension of micropseudopods toward adherent E-IgG, the formation of a linear uniform cap of roughly 200 A between opposing cell membranes, the ingestion of E-IgG by PE into a membrane-lined compartment, and the disintegration of the ingested ligand into membranous debris.
(3) Their defect in DNA degradation was shown not only after treatment by toluene but also in crude extracts after cell disintegration by ultrasonic and in untreated starved cultures.
(4) In order to identify these anchorage structures, the non-DNA materials that remain firmly bound to chromosomal DNA under conditions that disintegrate the high salt-stable architecture of nuclei were investigated.
(5) Bone cement particles promote polyethylene wear, which in turn promotes granuloma formation, bone resorption, and subsequent bone cement disintegration.
(6) The platelet disintegration is associated with a loss in the metabolic activity, discharge of LDH, increased susceptibility to phospholipid hydrolysis by phospholipase C and is found to be initiated during the actual preparation of platelet concentrates.
(7) By electron microscopy, accumulations of polymorphonuclear leukocytes in various degrees of disintegration were associated with areas of the basement membrane that appeared to be losing their structural integrity, suggesting that the damage to the membrane was brought about by the action of lysosomal enzymes.
(8) Scanning electronmicroscopy examination showed that the morphology of NCH blastula cells, which were obtained from the combination of Tilapia nucleus and goldfish cytoplasm, manifested obviously abnormal features and the cells were arrested at different stages of cell disintegration.
(9) The disruption by means of the Hews press yielded a more active preparation as compared with ultrasonic disintegration.
(10) And even after the disintegration of stone with ESWL, hydronephrosis remained due to ureteral stricture with small stone fragments.
(11) Cases of disintegrating pulmonary metastases are presented.
(12) To ascertain whether azo dyes are associated with risk of development of bladder tumors in workers who handpaint Yuzen-type silk kimonos in Kyoto, we investigated the disintegration of dyes to benzidine.
(13) During more extended exposure (60 and 90 days) the changes in hair cells of the spiral organ, which included nuclear deformation and disintegration of chromatin, mitochondria and endoplasmic reticulum membranes, became irreversible and caused the decay of injured cells.
(14) Corbyn’s ‘new politics’ is neither hateful nor pure: it’s complicated | John Harris Read more Their dilemma is plain: if they make a stand against what is happening, they stand accused of disloyalty by Corbyn’s supporters; but if they go along with it, they are complicit in Labour’s probable disintegration when voters realise the party has been taken over by people they can never vote for.
(15) The dissolution t50 and various pharmacokinetic parameters showed directly compressible starch and carboxymethylstarch to be the most effective disintegrants in the concentrations employed while magnesium aluminum silicate and microcrystalline cellulose were about equal but less effective than the previous disintegrants.
(16) At this stage it appeared as if the basement membrane had also begun to disintegrate.
(17) The effect of 5 per cent starch as a disintegrating agent in the tablet formulation was also studied.
(18) Finally they disintegrate to fragments which are mixed with MPS-granules.
(19) Incorporating polyvinylpyrrolidone, gelatin and methylcellulose binding agents in a metronidazole formulation alters the tensile strength, disintegration and dissolution times of the tablets by reducing their wettability as measured by the adhesion tension of water.
(20) Studies by light and electron microscopy showed that these histiocytes disintegrated to liberate their lamellar inclusions into the alveolar spaces, producing a picture reminiscent of alveolar proteinosis.