(v. t.) To strain apart; to sever by fracture; to divide with violence; as, to break a rope or chain; to break a seal; to break an axle; to break rocks or coal; to break a lock.
(v. t.) To lay open as by breaking; to divide; as, to break a package of goods.
(v. t.) To lay open, as a purpose; to disclose, divulge, or communicate.
(v. t.) To infringe or violate, as an obligation, law, or promise.
(v. t.) To interrupt; to destroy the continuity of; to dissolve or terminate; as, to break silence; to break one's sleep; to break one's journey.
(v. t.) To destroy the completeness of; to remove a part from; as, to break a set.
(v. t.) To destroy the arrangement of; to throw into disorder; to pierce; as, the cavalry were not able to break the British squares.
(v. t.) To shatter to pieces; to reduce to fragments.
(v. t.) To exchange for other money or currency of smaller denomination; as, to break a five dollar bill.
(v. t.) To destroy the strength, firmness, or consistency of; as, to break flax.
(v. t.) To weaken or impair, as health, spirit, or mind.
(v. t.) To diminish the force of; to lessen the shock of, as a fall or blow.
(v. t.) To impart, as news or information; to broach; -- with to, and often with a modified word implying some reserve; as, to break the news gently to the widow; to break a purpose cautiously to a friend.
(v. t.) To tame; to reduce to subjection; to make tractable; to discipline; as, to break a horse to the harness or saddle.
(v. t.) To destroy the financial credit of; to make bankrupt; to ruin.
(v. t.) To destroy the official character and standing of; to cashier; to dismiss.
(v. i.) To come apart or divide into two or more pieces, usually with suddenness and violence; to part; to burst asunder.
(v. i.) To open spontaneously, or by pressure from within, as a bubble, a tumor, a seed vessel, a bag.
(v. i.) To burst forth; to make its way; to come to view; to appear; to dawn.
(v. i.) To burst forth violently, as a storm.
(v. i.) To open up; to be scattered; to be dissipated; as, the clouds are breaking.
(v. i.) To become weakened in constitution or faculties; to lose health or strength.
(v. i.) To be crushed, or overwhelmed with sorrow or grief; as, my heart is breaking.
(v. i.) To make an abrupt or sudden change; to change the gait; as, to break into a run or gallop.
(v. i.) To fail in musical quality; as, a singer's voice breaks when it is strained beyond its compass and a tone or note is not completed, but degenerates into an unmusical sound instead. Also, to change in tone, as a boy's voice at puberty.
(v. i.) To fall out; to terminate friendship.
(v. t.) An opening made by fracture or disruption.
(v. t.) An interruption of continuity; change of direction; as, a break in a wall; a break in the deck of a ship.
(v. t.) A projection or recess from the face of a building.
(v. t.) An opening or displacement in the circuit, interrupting the electrical current.
(v. t.) An interruption; a pause; as, a break in friendship; a break in the conversation.
(v. t.) An interruption in continuity in writing or printing, as where there is an omission, an unfilled line, etc.
(v. t.) The first appearing, as of light in the morning; the dawn; as, the break of day; the break of dawn.
(v. t.) A large four-wheeled carriage, having a straight body and calash top, with the driver's seat in front and the footman's behind.
(v. t.) A device for checking motion, or for measuring friction. See Brake, n. 9 & 10.
(n.) See Commutator.
Example Sentences:
(1) Lucy and Ed will combine coverage of hard and breaking news with a commitment to investigative journalism, which their track record so clearly demonstrates”.
(2) They spend about 4.3 minutes of each working hour on a smoking break, the study shows.
(3) The mechanism by which pertussis toxin (PT) breaks the unresponsiveness of delayed-type hypersensitivity (DTH) to sheep red blood cells (SRBC) was examined in B10 mice.
(4) After absorption of labeled glucose, two pools of trehalose are found in dormant spores, one of which is extractable without breaking the spores, and the other, only after the spores are disintegrated.
(5) The following possible explanations were discussed: a) the tested psychotropic drugs block prostaglandin receptors in the stomach; b) the test substances react with prostaglandin in the nutritive solution; c) the substances stimulate metabolic processes in the stomach wall that break down prostaglandin.
(6) The ability of ligand to stimulate its own synthesis and that of its receptor suggests the presence of an autocrine positive feedback loop, however we were unable to break this loop in the breast cancer cells by antibodies that blocked the interaction of TGF alpha with the EGF receptor.
(7) Neutral sucrose density sedimentation patterns indicate that neutron-induced double strand-breaks sometimes occur in clusters of more than 100 in the same phage and that the effeciency with which double strand-breaks form is about 50 times that of gamma-induced double strand-breaks.
(8) Possible explanations of the clinical gains include 1) psychological encouragement, 2) improvements of mechanical efficiency, 3) restoration of cardiovascular fitness, thus breaking a vicous circle of dyspnoea, inactivity and worsening dyspnoea, 4) strengthening of the body musculature, thus reducing the proportion of anaerobic work, 5) biochemical adaptations reducing glycolysis in the active tissues, and 6) indirect responses to such factors as group support, with advice on smoking habits, breathing patterns and bronchial hygiene.
(9) At high luminances, the temporal, but not spatial, properties of this mechanism break down in a manner which had not been studied.Low-frequency inhibitory processThis process is manifest as a decrease in sensitivity from that of the simple excitatory process.
(10) These experiments represent the first occasion that the sequence specificity of a DNA damaging agent, which causes only double-strand breaks, has been determined to the exact base-pair in intact cells.
(11) The OPL first appears as a thin, discontinuous break in the cytoblast layer that is frequently interrupted by the profiles of migrating neuro- and glioblasts.
(12) Celebrity woodlanders Tax breaks and tree-hugging already draw the wealthy and well-known to buy British forests.
(13) But we need politicians to break out of historical routines.
(14) For Burroughs, who had been publishing ground-breaking books for 20 years without much appreciable financial return, it was association with fame and the music industry, as well as the possible benefits: a wider readership, film hook-ups and more money.
(15) Once you've invested many years in a career, figuring out how to take time out and then return to a role that's comparable to the one you left (or as comparable as you want it to be) requires more than confidence and enthusiasm - employers need to actively acknowledge the benefits of such breaks and be more receptive to those seeking to return”.
(16) A dose-dependent increase in chromatid lesions, i.e., achromatic lesions, chromatid breaks, chromatid deletions and triradial or quandriradial chromosomal exchange fiqures, was found.
(17) From the stress-strain curve the following values were selected: strain, stress, and slope at 80 mmHg equivalent pressure (1 mmHg = 133.3 Pa); maximum stress, strain, and slope; and breaking stress, strain, and slope if the sample broke.
(18) Everyone worked hard, but it is fair to pick out Willian because of his work-rate, quality on the ball, participation in the first goal and quality of the second.” It had been Willian’s fizzed cross, 11 minutes before the break, which Dragovic had nodded inadvertently inside Shovkovskiy’s near post to earn the hosts their initial lead.
(19) The possibility that mammalian DNA topoisomerase II is an intracellular target which mediates drug-induced DNA breaks is supported by the following studies using 4'-(9-acridinylamino)methane-sulfon-m-anisidide (m-AMSA): (a) a single m-AMSA-dependent DNA cleavage activity copurified with calf thymus DNA topoisomerase II activity at all chromatographic steps of the enzyme purification; (b) m-AMSA-induced DNA cleavage by this purified activity resulted in the covalent attachment of protein to the 5'-ends of the DNA via a tyrosyl phosphate bond.
(20) The authorities had said they used water cannon, teargas and smoke grenades to break up the protest.
Gap
Definition:
(n.) An opening in anything made by breaking or parting; as, a gap in a fence; an opening for a passage or entrance; an opening which implies a breach or defect; a vacant space or time; a hiatus; a mountain pass.
(v. t.) To notch, as a sword or knife.
(v. t.) To make an opening in; to breach.
Example Sentences:
(1) Linear and annular gap junctions between neighbouring cells were present, particularly in Group 1.
(2) We conclude that removal of dimers and repair of gaps were similar in all cases.
(3) Hence the major role of the 14-A arm of carboxybiotin is not to permit a large carboxyl migration but, rather to permit carboxybiotin to traverse the gap which occurs at the interface of three subunits and to insinuate itself between the CoA and keto acid sites.
(4) The junctional currents were already constant 1 ms after step changes in the junctional voltage; this was three orders of magnitude faster than the other known examples of voltage-controlled gap junctions between embryonic cells.
(5) These two enzymes may act jointly in filling up the gaps along the DNA molecule and elongating the DNA chain.
(6) Preliminary hearing results of 45 cases show air-bone gap closure of 67% within 10 dB and 98% within 20 dB.
(7) Measurements were made of the width of the marginal gap for three sites at each of four stages: (1) after the shoulder firing, (2) after the body-incisal firing, (3) after the glaze firing, and (4) after a correction firing.
(8) Office of National Statistics figures published in November last year showed that men earn 9.4% more than women, the lowest gender gap since records began in 1997.
(9) To a large extent, the failure has been a consequence of a cold war-style deadlock – Russia and Iran on one side, and the west and most of the Arab world on the other – over the fate of Bashar al-Assad , a negotiating gap kept open by force in the shape of massive Russian and Iranian military support to keep the Syrian regime in place.
(10) These activities define both the polarity of the anterior-posterior (AP) axis and the spatial domains of expression of the zygotic gap genes, which in turn control the subsequent steps in segmentation.
(11) After loss of permanent central incisors the treatment of choice could be either orthodontic closure or maintenance of the gap for a replacement-prosthetic, autotransplantation or implant.
(12) PTH, an inducer of shape change, did not affect the number of gap junctions appreciably.
(13) The primary aim of future work must still be directed toward preventing the formation of a gap between the restoration and the tooth.
(14) Since testosterone influenced both tissue stores and PDBu-stimulated secretion of LHRH and GAP, this steroid may selectively regulate biosynthesis and secretion of pro-LHRH-derived peptides through activation of the metabolic cascade involving the PKC system.
(15) Microsequencing of the peptides resolved by sodium dodecyl sulfate-polyacrylamide gel electrophoresis indicates that the amino terminus of the protein is disposed at or near the cytoplasmic surface of the gap junction, and that this surface also contains a protease-hypersensitive hydrophilic sequence between residues 109 and 123, presumably connecting the second and third transmembrane segments.
(16) The present investigation shows that the intramembranous proteins of tight and gap junctions are mobile structures within the fluid membrane.
(17) The report also recommends including justice and victim of violence targets in the national Closing the Gap strategy, recognising foetal alcohol spectrum disorders as a disability before the courts, and making a national commitment to a justice reinvestment approach to find community-based solutions to youth crime.
(18) Regions within the desmosome where the two plasma membranes converged suggested that gap junctions were a component of the desmosome-like junctions.
(19) The frequency of chromosome and chromatid gaps and chromosome deletions was significantly higher among workers than among controls, and the same was true for the number of individuals with some type of chromosome alteration.
(20) Gap junctions were of different sizes and frequently composed of a small number of connexons organized in polygonal aggregates or linear arrays.