(a.) Having dark streaks or spots on a gray or tawny ground; brinded.
Example Sentences:
(1) The brindled mottled mutant mouse, a model of Menkes' disease, has alterations in copper homeostasis which cause, among other sequelae, neuronal degeneration in selected areas of brain.
(2) David Brindle is the Guardian’s public services editor Read more • New series: careers in public services • Why there won’t be mass redundancies in the public sector after the election This article is part of our series on careers in public services .
(3) Neuropathological and enzyme-histochemical studies were performed on brindled mouse hemizygotes (BMs) and normal littermates at the age of 2 days, 7 days, 11 days and 14 days, together with an investigation of their tissue copper levels.
(4) During early development normal and brindled mouse brain use 3-hydroxy-butyrate preferentially to glucose as a source for biosynthetic carbon units.
(5) The most extensively investigated mutants are the mottled mice, in particular brindled mice, which have a mutation analogous to that of Menkes' disease.
(6) Irrespective of how the low levels of the approximately 48-kDa protein may be related to the basic defect in the brindled mice, the data are consistent with an important role for the approximately 48-kDa protein in intracellular copper metabolism.
(7) Brindled mice, which have a genetic defect that affects copper distribution, were compared to their normal brothers.
(8) These results suggest that fetal brain abnormalities caused by Trien-2HCl may be due in part to induction of copper deficiency, which is almost equivalent to that in brindled mutant mouse.
(9) Decreased copper binding and approximately 48-kDa protein were not simply secondary to the abnormal hepatic and renal copper levels that are found in the brindled mice since although their liver copper levels are low, their kidney copper levels are high.
(10) Copper (6 ppm) was administered to pregnant heterozygous brindled and normal mice from 13 to 18 days gestation.
(11) Brindled mice from dams on the -Cu treatment were smaller and had lower packed cell volumes than brindled mice from dams on the +Cu treatment.
(12) Most of the copper in the cytosol of these fibroblasts is bound to metallothionein (MT), which is elevated in Menkes or brindled mouse fibroblasts.
(13) Proteolytically generated fragments of the microfilament anchoring protein brain spectrin were found to accumulate in brindled mouse brain.
(14) At the table David Brindle (Chair) Public services editor, the Guardian Sharon Allen Chief executive, Skills for Care Pete Calveley Chief executive, Barchester Healthcare Michelle Dudderidge Director, Hand in Hands Shaks Ghosh Chief executive, Clore Social Leadership Programme Patrick Vernon Project coordinator, Health Partnership Project, National Housing Federation Martin Green Chief executive, Care England Ray James President, Association of Directors of Adult Social Services in England Des Kelly Executive director, National Care Forum John Kennedy Director of care services, Joseph Rowntree Foundation Neil Matthewman Chief executive, Community Integrated Care John Ransford Non-executive director, HC-One Jon Glasby Professor of health and social care, University of Birmingham Bridget Warr Chief executive, UK Home Care Association There was a recognition from participants that there were some great leaders in social care – but that there was room for improvement, too.
(15) These data show that female brindled mice have neurochemical abnormalities similar to (if less severe than) the male hemizygotes, that these abnormalities are regionally specific, are most apparent prior to 30 days of age, and are linked to behavioral deficits.
(16) Histochemical examinations showed no significant differences in the stainability, morphology and distribution of MAO positive neurons in the brain between normal and brindled mice at the same age.
(17) Copper accumulation by normal fibroblasts containing excess MT was examined to determine if the excess copper accumulation phenotype was secondary to excess MT or associated with the primary defect in fibroblasts from the brindled mice.
(18) Nucleotide levels were low in spleens from brindled mice.
(19) Deficits in oxidative and acetylcholine metabolism occur in the developing brindled mouse, a genetic mutant with a defect in copper homeostasis.
(20) In order to investigate the levels of cytochrome oxidase activity in neuronal mitochondria in the brain of the brindled mouse hemizygote (BM), the cerebella and brain stems from 12 pairs of brindled and normal littermates aged 13-16 days were examined.
Gray
Definition:
(superl.) White mixed with black, as the color of pepper and salt, or of ashes, or of hair whitened by age; sometimes, a dark mixed color; as, the soft gray eye of a dove.
(superl.) Gray-haired; gray-headed; of a gray color; hoary.
(superl.) Old; mature; as, gray experience. Ames.
(n.) A gray color; any mixture of white and black; also, a neutral or whitish tint.
(n.) An animal or thing of gray color, as a horse, a badger, or a kind of salmon.
Example Sentences:
(1) The anatomic and functional development of the suprachiasmatic nuclei (SCN) was studied in the gray short-tailed opossum, Monodelphis domestica.
(2) While the heaviest anterogradely labeled ascending projections were observed to the contralateral ventral posterolateral nucleus of the thalamus, pars oralis (VPLo), efferent projections were also observed to the contralateral ventrolateral thalamic nucleus (VLc) and central lateral (CL) nucleus of the thalamic intralaminar complex, magnocellular (and to a lesser extent parvicellular) red nucleus, nucleus of Darkschewitsch, zona incerta, nucleus of the posterior commissure, lateral intermediate layer and deep layer of the superior colliculus, dorsolateral periaqueductal gray, contralateral nucleus reticularis tegmenti pontis and basilar pontine nuclei (especially dorsal and peduncular), and dorsal (DAO) and medial (MAO) accessory olivary nuclei, ipsilateral lateral (external) cuneate nucleus (LCN) and lateral reticular nucleus (LRN), and to a lesser extent the caudal medial vestibular nucleus (MVN) and caudal nucleus prepositus hypoglossi (NPH), and dorsal medullary raphe.
(3) There was good agreement between the survival of normally oxygenated cells in culture and bright cells from tumors and between hypoxic cells in culture and dim cells from tumors over a radiation dosage range of 2-5 Gray.
(4) White lesions (NRL) against a gray background on cut section of brain increase in size with increasing time of arrest.
(5) Paul Doyle Kick-off Sunday midday Venue St Mary’s Stadium Last season Southampton 2 Leicester City 2 Live Sky Sports 1 Referee Michael Oliver This season G 18, Y 60, R 1, 3.44 cards per game Odds H 5-6 A 4-1 D 5-2 Southampton Subs from Taylor, Martina, Stephens, Davis, Rodriguez, Sims, Ward-Prowse Doubtful Bertrand, Davis, Van Dijk (all match fitness) Injured Boufal (knee, Jan), Hesketh (ankle, Feb), Targett (hamstring, Feb), Austin (shoulder, Mar), Pied (knee, Jun), Gardos (knee, unknown) Suspended None Form DWLLLL Discipline Y37 R2 Leading scorer Austin 6 Leicester City Subs from Zieler, Hamer, Wasilewski, Gray, Fuchs, James, Okazaki, Hernández, Kapustka, King Doubtful None Injured None Suspended None Unavailable Amartey, Mahrez, Slimani (Africa Cup of Nations) Form LDLWDL Discipline Y44 R1 Leading scorers Slimani, Vardy 5
(6) Proenkephalin A-related immunoreactive neuronal perikarya were detected in the central gray, reticular formation, nucleus raphes, trapezoid body, nucleus parabrachialis lateralis and medialis, nucleus spinalis nervi trigemini, nucleus dorsalis nervi vagi, and in the nucleus tractus solitarii.
(7) Ratios of lobar to global gray matter metabolism also were calculated.
(8) To summarize this case, one should consider the possibility that excessive polytherapy induces seizures, particularly in patients with structural brain abnormalities such as heterotopic gray matter.
(9) But Vokes’s second-half penalty and Gray’s 61st-minute strike won it for Burnley and left Fulham two points away from the relegation zone.
(10) Low numbers of [125I]endothelin-1 [( 125I]ET-1) binding sites were detected in the gray matter of the human frontal cortex, with little binding in the white matter.
(11) North Wiltshire MP James Gray said he was "very glad" Islam4UK had abandoned its march, which he said had been shown to be a "media stunt".
(12) Total RNA extracted from both white and gray matter of brain tissue from multiple sclerosis (MS) patients and controls was analyzed using a reverse transcription-polymerase chain reaction for the presence of the nucleic acid of human coronavirus (HCV) 229E and OC43, the two strains characterized to date and associated with respiratory infections.
(13) Bouton-like terminals were found to be of two types according to their vesicle content, namely, boutons with ovoid, clear synaptic vesicles forming Gray type-1 synapses and boutons with pleomorphic clear synaptic vesicles forming Gray type-2 synapses.
(14) These findings support the view that the periaqueductal gray matter is actively involved in endogenous mechanisms of analgesia.
(15) I want to make it very clear that the state’s attorney’s office did not release the Freddie Gray autopsy report,” she said.
(16) ruber, anterodorsolateral midbrain tegmentum, superior and inferior colliculi, pontine gray, cerebral peduncles, medial pontine reticular formation, raphe and vestibular nuclei did not affect the acoustic structure of the calls tested.
(17) Single axon collaterals arising from the descending axons gave off terminal fibers to the left or the right gray matter.
(18) Colloidal gold labeled with monoclonal antibody recognized human hemoglobin was agglutinated with hemoglobin and changed the color from red to gray.
(19) Facebook Twitter Pinterest A child praying at the vigil site for Freddie Gray in Baltimore.
(20) Phoenix will next be seen in James Gray's Lowlife, a historical drama about immigrants in 1900s New York.