(a.) Having dark streaks or spots on a gray or tawny ground; brinded.
Example Sentences:
(1) The brindled mottled mutant mouse, a model of Menkes' disease, has alterations in copper homeostasis which cause, among other sequelae, neuronal degeneration in selected areas of brain.
(2) David Brindle is the Guardian’s public services editor Read more • New series: careers in public services • Why there won’t be mass redundancies in the public sector after the election This article is part of our series on careers in public services .
(3) Neuropathological and enzyme-histochemical studies were performed on brindled mouse hemizygotes (BMs) and normal littermates at the age of 2 days, 7 days, 11 days and 14 days, together with an investigation of their tissue copper levels.
(4) During early development normal and brindled mouse brain use 3-hydroxy-butyrate preferentially to glucose as a source for biosynthetic carbon units.
(5) The most extensively investigated mutants are the mottled mice, in particular brindled mice, which have a mutation analogous to that of Menkes' disease.
(6) Irrespective of how the low levels of the approximately 48-kDa protein may be related to the basic defect in the brindled mice, the data are consistent with an important role for the approximately 48-kDa protein in intracellular copper metabolism.
(7) Brindled mice, which have a genetic defect that affects copper distribution, were compared to their normal brothers.
(8) These results suggest that fetal brain abnormalities caused by Trien-2HCl may be due in part to induction of copper deficiency, which is almost equivalent to that in brindled mutant mouse.
(9) Decreased copper binding and approximately 48-kDa protein were not simply secondary to the abnormal hepatic and renal copper levels that are found in the brindled mice since although their liver copper levels are low, their kidney copper levels are high.
(10) Copper (6 ppm) was administered to pregnant heterozygous brindled and normal mice from 13 to 18 days gestation.
(11) Brindled mice from dams on the -Cu treatment were smaller and had lower packed cell volumes than brindled mice from dams on the +Cu treatment.
(12) Most of the copper in the cytosol of these fibroblasts is bound to metallothionein (MT), which is elevated in Menkes or brindled mouse fibroblasts.
(13) Proteolytically generated fragments of the microfilament anchoring protein brain spectrin were found to accumulate in brindled mouse brain.
(14) At the table David Brindle (Chair) Public services editor, the Guardian Sharon Allen Chief executive, Skills for Care Pete Calveley Chief executive, Barchester Healthcare Michelle Dudderidge Director, Hand in Hands Shaks Ghosh Chief executive, Clore Social Leadership Programme Patrick Vernon Project coordinator, Health Partnership Project, National Housing Federation Martin Green Chief executive, Care England Ray James President, Association of Directors of Adult Social Services in England Des Kelly Executive director, National Care Forum John Kennedy Director of care services, Joseph Rowntree Foundation Neil Matthewman Chief executive, Community Integrated Care John Ransford Non-executive director, HC-One Jon Glasby Professor of health and social care, University of Birmingham Bridget Warr Chief executive, UK Home Care Association There was a recognition from participants that there were some great leaders in social care – but that there was room for improvement, too.
(15) These data show that female brindled mice have neurochemical abnormalities similar to (if less severe than) the male hemizygotes, that these abnormalities are regionally specific, are most apparent prior to 30 days of age, and are linked to behavioral deficits.
(16) Histochemical examinations showed no significant differences in the stainability, morphology and distribution of MAO positive neurons in the brain between normal and brindled mice at the same age.
(17) Copper accumulation by normal fibroblasts containing excess MT was examined to determine if the excess copper accumulation phenotype was secondary to excess MT or associated with the primary defect in fibroblasts from the brindled mice.
(18) Nucleotide levels were low in spleens from brindled mice.
(19) Deficits in oxidative and acetylcholine metabolism occur in the developing brindled mouse, a genetic mutant with a defect in copper homeostasis.
(20) In order to investigate the levels of cytochrome oxidase activity in neuronal mitochondria in the brain of the brindled mouse hemizygote (BM), the cerebella and brain stems from 12 pairs of brindled and normal littermates aged 13-16 days were examined.
Spotted
Definition:
(imp. & p. p.) of Spot
(a.) Marked with spots; as, a spotted garment or character.
Example Sentences:
(1) O'Connell first spotted 14-year-old David Rudisha in 2004, running the 200m sprint at a provincial schools race.
(2) These lanes encourage cyclists to 'ride in the gutter' which in itself is a very dangerous riding position – especially on busy congested roads as it places the cyclist right in a motorist's blind spot.
(3) The effect of the mutation for white belly spot controlled by the dominant gene W on spermatogenesis in mice was examined by experimental cryptorchidism and its surgical reversal.
(4) Moments later, explosive charges blasted free two tungsten blocks, to shift the balance of the probe so it could fly itself to a prearranged landing spot .
(5) Our findings: (1) both forms, LC1 and LC3, migrate in the two species with rather similar electrophoretic constants (both in terms of pI and Mr); (2) the LC2 forms of rabbit and humans exhibit the same Mr but quite different pI values, the rabbit forms being more acidic; (3) the chain LC2Sb is resolved into two spots in both rabbit and humans.
(6) You just have to be the first person to spot a coach.
(7) The overall effect achieved with LTS was less than that with LTP, but it is possible to reduce IOP by selecting more reasonable parameters, e.g., a laser setting of 200mW, a 50 microns spot size and a 0.5 to 1-sec duration.
(8) The average repetitive yields and initial coupling of proteins spotted or blotted into PVDF membranes ranged between 84-98% and 30-108% respectively, and were comparable with the yields measured for proteins spotted onto Polybrene-coated glass fiber discs.
(9) In north-west Copenhagen, among the quiet, graffiti-tagged streets of red-brick blocks and low-rise social housing bordering the multi-ethnic Nørrebro district, police continued to cordon off roads and search a flat near the spot where officers killed a man believed to be behind Denmark’s bloodiest attacks in over a decade.
(10) Detection limits were then calculated for the different sizes of cold spots.
(11) These complications were believed to be caused by the use of a small spot size with high energy.
(12) In the brownish skin and in the black spots of the dorsal region all types of chromatophores are found.
(13) I can always spot something for my sisters Gretchen and Amy.
(14) Debeaking had no effect on the incidence of blood-spotting in the eggs.
(15) Six abnormal colonoscopic appearances were documented, namely mucosal edema, ulcers, friability, punctate spots, erythematous areas and luminal exudate.
(16) The town's Castle Hill is the perfect climb for travellers with energy to burn off: at the top is a picnic spot with far-reaching views, and there is a small children's play area at its foot.
(17) This appears to be a newly described entity, although it resembles a Becker's nevus without hypertrichosis or an typical café au lait spot.
(18) A £100,000 bronze statue of an ordinary family, the Joneses, will be unveiled in a prime spot outside the city’s library which opened last year.
(19) When delta phi was enlarged, first saccades were either directed near the green or the red spot (bistable response mode).
(20) Join us for a spot of future gazing as we discuss: The challenges and opportunities colleges and training providers will face over the next five years International expansion The role of FE in higher education New ways to diversify New technology – the possibilities and risks.