(a.) Having dark streaks or spots on a gray or tawny ground; brinded.
Example Sentences:
(1) The brindled mottled mutant mouse, a model of Menkes' disease, has alterations in copper homeostasis which cause, among other sequelae, neuronal degeneration in selected areas of brain.
(2) David Brindle is the Guardian’s public services editor Read more • New series: careers in public services • Why there won’t be mass redundancies in the public sector after the election This article is part of our series on careers in public services .
(3) Neuropathological and enzyme-histochemical studies were performed on brindled mouse hemizygotes (BMs) and normal littermates at the age of 2 days, 7 days, 11 days and 14 days, together with an investigation of their tissue copper levels.
(4) During early development normal and brindled mouse brain use 3-hydroxy-butyrate preferentially to glucose as a source for biosynthetic carbon units.
(5) The most extensively investigated mutants are the mottled mice, in particular brindled mice, which have a mutation analogous to that of Menkes' disease.
(6) Irrespective of how the low levels of the approximately 48-kDa protein may be related to the basic defect in the brindled mice, the data are consistent with an important role for the approximately 48-kDa protein in intracellular copper metabolism.
(7) Brindled mice, which have a genetic defect that affects copper distribution, were compared to their normal brothers.
(8) These results suggest that fetal brain abnormalities caused by Trien-2HCl may be due in part to induction of copper deficiency, which is almost equivalent to that in brindled mutant mouse.
(9) Decreased copper binding and approximately 48-kDa protein were not simply secondary to the abnormal hepatic and renal copper levels that are found in the brindled mice since although their liver copper levels are low, their kidney copper levels are high.
(10) Copper (6 ppm) was administered to pregnant heterozygous brindled and normal mice from 13 to 18 days gestation.
(11) Brindled mice from dams on the -Cu treatment were smaller and had lower packed cell volumes than brindled mice from dams on the +Cu treatment.
(12) Most of the copper in the cytosol of these fibroblasts is bound to metallothionein (MT), which is elevated in Menkes or brindled mouse fibroblasts.
(13) Proteolytically generated fragments of the microfilament anchoring protein brain spectrin were found to accumulate in brindled mouse brain.
(14) At the table David Brindle (Chair) Public services editor, the Guardian Sharon Allen Chief executive, Skills for Care Pete Calveley Chief executive, Barchester Healthcare Michelle Dudderidge Director, Hand in Hands Shaks Ghosh Chief executive, Clore Social Leadership Programme Patrick Vernon Project coordinator, Health Partnership Project, National Housing Federation Martin Green Chief executive, Care England Ray James President, Association of Directors of Adult Social Services in England Des Kelly Executive director, National Care Forum John Kennedy Director of care services, Joseph Rowntree Foundation Neil Matthewman Chief executive, Community Integrated Care John Ransford Non-executive director, HC-One Jon Glasby Professor of health and social care, University of Birmingham Bridget Warr Chief executive, UK Home Care Association There was a recognition from participants that there were some great leaders in social care – but that there was room for improvement, too.
(15) These data show that female brindled mice have neurochemical abnormalities similar to (if less severe than) the male hemizygotes, that these abnormalities are regionally specific, are most apparent prior to 30 days of age, and are linked to behavioral deficits.
(16) Histochemical examinations showed no significant differences in the stainability, morphology and distribution of MAO positive neurons in the brain between normal and brindled mice at the same age.
(17) Copper accumulation by normal fibroblasts containing excess MT was examined to determine if the excess copper accumulation phenotype was secondary to excess MT or associated with the primary defect in fibroblasts from the brindled mice.
(18) Nucleotide levels were low in spleens from brindled mice.
(19) Deficits in oxidative and acetylcholine metabolism occur in the developing brindled mouse, a genetic mutant with a defect in copper homeostasis.
(20) In order to investigate the levels of cytochrome oxidase activity in neuronal mitochondria in the brain of the brindled mouse hemizygote (BM), the cerebella and brain stems from 12 pairs of brindled and normal littermates aged 13-16 days were examined.
Tabby
Definition:
(v. t.) To water; to cause to look wavy, by the process of calendering; to calender; as, to tabby silk, mohair, ribbon, etc.
(n.) A kind of waved silk, usually called watered silk, manufactured like taffeta, but thicker and stronger. The watering is given to it by calendering.
(n.) A mixture of lime with shells, gravel, or stones, in equal proportions, with an equal proportion of water. When dry, this becomes as hard as rock.
(n.) A brindled cat; hence, popularly, any cat.
(n.) An old maid or gossip.
(a.) Having a wavy or watered appearance; as, a tabby waistcoat.
(a.) Brindled; diversified in color; as, a tabby cat.
Example Sentences:
(1) Looking up we saw a large tabby on top of a wooden hoarding which was covering a building site in Vauxhall.
(2) I have suggested that the X-linked gene Tabby (Ta) and its autosomal mimics in the mouse may be homologous with the genes for sex-linked anhidrotic (hypohidrotic) ectodermal dysplasia (Christ-Siemens-Touraine syndrome, CST) and its apparent autosomal mimics in the human.
(3) Tabby (Ta), a murine X-linked mutant gene, produces a syndrome of ectodermal dysplasia including anhidrosis (absence of sweat glands).
(4) The findings have potential clinical significance; firstly, because the Tabby gene shows genetic homology to the human gene for hypohidrotic ectodermal dysplasia, and disturbed eyelid opening is a trait of some forms of human ectodermal dysplasia, and secondly, because the gene for epidermal growth factor receptor is an oncogene.
(5) It is possible that deficiency of epidermal growth factor at the tissue level may be involved in the development of some of the traits seen in Tabby mutants.
(6) In addition to analysing the effects of the Tabby gene and of epidermal growth factor on eyelid opening in the mouse, this study appears to be the first detailed histological description of normal eyelid opening.
(7) These probes have been positioned with respect to existing DNA markers utilizing a new interspecific backcross segregating for the Tabby (Ta) locus.
(8) Because Tabby appears to be genetically homologous to the gene for human X-linked hypohidrotic ectodermal dysplasia, these results may have potential clinical significance.
(9) We have also demonstrated that tabby has abnormally elevated epidermal sulphydryl (SH): disulphide (SS) ratios, in common with an autosomal form of ectodermal dysplasia.
(10) Three alleles of the tabby locus (T) have been identified, namely, Abyssinian (Ta), striped (T), and blotched (tb).
(11) Studies from our laboratory have previously shown that the syndrome produced in the mouse by the X-linked gene tabby (Ta) has many features in common with human X-linked hypohidrotic ectodermal dysplasia.
(12) The preputial gland can be excluded as the site of pheromone synthesis since males which are hemizygous for the Tabby-J gene and have no preputial glands blocked pregnancies as effectively as their normal littermates.
(13) Both sequences map to the region of 10 centimorgan lying between the Tabby (Ta) and St14-1 (DxPas8) loci, close to the phosphorylase b kinase locus (Phk).
(14) Nor is it easy to determine how much hybridisation has occurred between the Scottish wildcat, a close relative of the European wildcat, and the domestic tabby, a cousin of the near-eastern wildcat, a separate subspecies.
(15) The first is the apparent absence of blotched tabby and a relatively high frequency of Abyssinian tabby.
(16) We tried to measure the distances between arterioles in about 30 postmortem injected hearts using India ink to produce a kind of reflected imitated tabby (tiger) heart pattern.
(17) Thus epidermal growth factor appears to accelerate eyelid opening by stimulating these morphological processes and the Tabby gene appears to delay eyelid opening by impairing them.
(18) We performed histological studies to explore the mechanisms of action of the Tabby gene and of epidermal growth factor in these processes.
(19) Linkage data relative to the markers tabby and glucose-6-phosphate dehydrogenase are presented to locate X-linked cataract (Xcat) in the distal portion of the mouse X-chromosome between jimpy and hypophosphatemia.
(20) Grafts of the combination tabby epidermis-normal dermis and tabby epidermis-tabby dermis produced hairs with a morphology similar to hairs found in tabby mice.