(n.) A powerful vegetable alkaloid, found, associated with strychnine, in the seeds of different species of Strychnos, especially in the Nux vomica. It is less powerful than strychnine. Called also brucia and brucina.
Example Sentences:
(1) The strychnine-like effect was common to other glycine-antagonist tested, such as brucine, morphine and laudanosine.
(2) The hyper-irritability elicited by picrotoxin or penicillin G-K was associated with a relatively localized trigger zone in the face, while that elicited by strychnine or brucine spread beyond the trigeminal region to the first cervical dermatome.
(3) In the presence of large amounts of strychnine, brucine is isolated prior to colorimetric analysis by a quantitative thin layer chromatographic technique.
(4) This paper reports the determination of strychnine and brucine in different parts of Semen Strychni (the seeds of Strychnos nux-vomica and S. pierriana), and makes a comparison of the contents between the crude forms and processed products of the two seeds.
(5) Bisnor-dihydrotoxiferine seems to give dichlorometho compounds and N-oxides easily, analogous with strychnine and brucine.
(6) When the effects of quinine, brucine and caffeine on electrical responses in taste cells were examined, they all produced a depolarization associated with an increased input resistance.
(7) Sodium chloride (1,000 mM) enhanced the affinity of strychnine, brucine, isostrychnine, and the nonselective GABA antagonist pitrazepin for [3H]strychnine binding sites, whereas the affinities of glycine, beta-alanine, and taurine were reduced.
(8) The second was developed for the determination of brucine and is based on measuring the intensity of the violet color produced by treating brucine with nitric acid and methanolic stannous chloride.
(9) In contrast, brucine, the 2,3-dimethoxy derivative of strychnine, caused no increase in duplication frequencies under the identical conditions.
(10) The TMA curves of brucine, griseofulvin and phenobarbital were similar to that of indomethacin.
(11) We found that inferior olive lesioned rats had lower threshold to seizures induced by strychnine and brucine, both glycine antagonists.
(12) The natural abundance 13C-NMR spectra of brucine and strychnine were obtained using the pulse Fourier transform technique.
(13) The paper reports the experimental result of the simultaneous quantitative determination of strychnine (ST) and brucine(BR) in Semen Strychni by dual wavelength spectrophotometry.
(14) Nitrate were determined by the brucine method, while nitrates by the Griess colorimetric method.
(15) The CMA was thought to be of L(+)-form based on the results of optical resolution with brucine and also its susceptibility to L(+)-citramalate lyase of Clostridium tetanomorphum.
(16) In vitro, amoxapine and brucine most effectively reversed the inhibitory action of GABA on 35S-TBPS binding.
(17) Binding was completely inhibited by glycine, alanine, alpha-aminobutyric acid, beta-aminoisobutyric acid, hypotaurine and strychnine, and to a lesser extent by 2,2-dimethyl-beta-alanine, brucine and gelsemine.
(18) On heat treatment, the contents of the major alkaloids such as strychnine and brucine declined significantly with increases in the amounts of isostrychnine, isobrucine, strychnine N-oxide and brucine N-oxide.
(19) 5-(3-Hydroxyphenyl)-5-phenylhydantoin (m-HPPH) has been resolved by crystallization of the brucine salts.
(20) Contents of strychnine and brucine in dry seeds of Strychnos nux-vomica and its preparations were determined by gas chromatography.
Strychnine
Definition:
(n.) A very poisonous alkaloid resembling brucine, obtained from various species of plants, especially from species of Loganiaceae, as from the seeds of the St. Ignatius bean (Strychnos Ignatia) and from nux vomica. It is obtained as a white crystalline substance, having a very bitter acrid taste, and is employed in medicine (chiefly in the form of the sulphate) as a powerful neurotic stimulant. Called also strychnia, and formerly strychnina.
Example Sentences:
(1) The in vitro metabolism of strychnine was studied in the 9000g supernatant fractions from rat and rabbit livers.
(2) 5 alpha-Pregnan-3 alpha-ol-20-one protected mice against metrazol-, bicuculline- and picrotoxin-induced seizures but not against electroshock-and strychnine-induced seizures.
(3) Pre-treatment with subconvulsive doses of strychnine, an antagonist of the neurotransmitter glycine, partially or completely blocked the inhibitory effects on phrenic activity of muscle-afferent stimulation.
(4) From a comparison of activation by strychnine and picrotoxin in normal and chronically decapitated embryos it was deduced that a spinal and a supraspinal component participated in their effect.
(5) Injections of glycine or strychnine (10--100 micrograms) into one SN induced slow ipsiversive or contraversive turning respectively.
(6) alpha-Bungarotoxin (10(-7) M), decamethonium (10(-5) M), d-tubocurarine (5 X 10(-5) M), and strychnine (5 X 10(-5) M) blocked the carbachol depolarization by about 90%.
(7) The action of strychnine and picrotoxin on the values of different reflex components was not identical; this pointed to a different localization of the inhibitory action of GABA and glycine in the central link of the somatosympathetic reflex arch.
(8) The inhibitory effect of bicuculline and strychnine was accompanied by vigorous convulsions.
(9) To determine whether the inhibitory neurotransmitter, glycine, contributes to the action of VS, strychnine, a specific glycine receptor antagonist was administered perispinally via intrathecal catheter in dosages of 1,5,25 and 100 micrograms.
(10) These findings demonstrate that strychnine-induced motor evoked potential changes arise from spinal gray activity induced by efferent pathways activated during transcortical stimulation.
(11) With strychnine, specific antagonist of glycine, excitation prevailed in EI, I and E neurons.
(12) While NAL and OXO did not alter the threshold for convulsions induced by PTZ, strychnine or picrotoxin, both agents lowered the threshold for electroshock-induced seizures.
(13) The intracisternal injection of HEPB or gamma-aminobutyric acid (GABA) in mice resulted in a potentiation of strychnine-induced convulsions.
(14) The effect of equimolar doses of glycine (G) and some related amino acids: beta-alanine (A), taurine (T) and betaine (B) on the strychnine syndrome was tested by administering them (intrathecal route) along with strychnine.
(15) MDL 27,531, which acts functionally like a glycine agonist in its capacity to selectively reverse seizures produced by the glycine antagonist strychnine, was evaluated in a model of spinal injury-induced reflex dysfunction.
(16) Strychnine blockade was also reversed by Cdp (10 micrometer).
(17) A focus of more powerful excitation created with the same strychnine played the role of determinant despatch station (DDS).
(18) The efflux of taurine was unaffected by strychnine, picrotoxin, tubocurarine, atropine, chlorpromazine, and 2-amino-4-phosphonobutyrate, whereas it was increased by glutamate diethyl esther and alpha-amino adipate.
(19) Some neurones failed to demonstrate this behaviour following the administration of strychnine.
(20) Strychnine improved the patient's motoricity presumably by blocking the excessive glycine-mediated inhibition of motoneurons.