(n.) One guilty of buggery or unnatural vice; a sodomite.
(n.) A wretch; -- sometimes used humorously or in playful disparagement.
Example Sentences:
(1) There's a stunning atmosphere in Wembley tonight, one even the Sheffield Wednesday band can't bugger up.
(2) If they try, they invariably bugger up the punchline.
(3) If Rooney is having a bad game (as he did against Algeria) England are buggered.
(4) The ref blows for a free kick, but doesn't book the saucy bugger.
(5) Very rarely now, but it still does happen that some police officer still does think, ‘Bugger that, I won’t make the call this time.’ “If they then try to use any evidence they obtained from that Aboriginal person, we’re very confident that any court will exclude that evidence,” he said.
(6) ", seconds before splashing about in the sub-zero Atlantic muttering "bugger".
(7) Stoke City and England defender Neil Franklin was the first to think BUGGER THAT, and along with team-mate George Mountford, agreed a move to Santa Fe in the summer of 1950.
(8) Michael Buerk would be there, trying to calm things, and behind him, through the window, I could see the producer mouthing the words: 'Fuck the bugger!'
(9) The French left’s preference for in-your-face secularism and scatologically offensive satire goes back to the Jacobins, for whom the words “priest, bugger and fuck” were in the core political vocabulary.
(10) As the buggered ploughs and botched pottage mounted, any residual rose-tinted sentimentality flaked off like the skin of a psoriatic shire horse.
(11) I wandered down to the local shop, and mumbled something about cigarettes, and was served: it wasn't until a day or two later that I realised my speech had become a bit buggered-about-with as well.
(12) But he told me he was housemaster in a home and he would say they were bad buggers in there and you have to discipline them.
(13) In a gag over the former Have I Got News For You star reading out his bank details, Deayton inadvertently said: "Bugger, yes."
(14) The ones who, when faced with a massive terrifying conspiracy, will offer just a weary sniff of "bugger to that, chuck".
(15) In my best Australian, total buggeration.” Prideaux scoffed at the theory shared by some local people that big landowners secretly favoured HS2 because they will make millions.
(16) The bugger who stabbed me, I'm the fourth person he had stabbed."
(17) I went to fill, from the cold tap in the kitchen, the glass percolator, and my cuffs (now I come to think about it, they had been a real bugger) managed to catch two plates from the night before and send them, breaking, to the floor.
(18) Just kidnap the bugger, like they did to Eichmann,” he added in a comment, referring to the Nazi war criminal Adolf Eichmann, who was captured in Argentina in 1960 and put on trial in Israel.
(19) As I stood just outside the ring of onlookers, a Ukip member leaned close to my ear and said, “If he went under a bus tomorrow, we’d be buggered.” On election day Ukip supporters were offered a glimpse of just such a future when Farage was injured in a light aircraft crash .
(20) If you're staying here, food and wine are included in the rate, and if you're here, you may as well stay because it's a bugger to get back to the coast after dark.
Chap
Definition:
(v. t.) To cause to open in slits or chinks; to split; to cause the skin of to crack or become rough.
(v. t.) To strike; to beat.
(v. i.) To crack or open in slits; as, the earth chaps; the hands chap.
(v. i.) To strike; to knock; to rap.
(n.) A cleft, crack, or chink, as in the surface of the earth, or in the skin.
(n.) A division; a breach, as in a party.
(n.) A blow; a rap.
(n.) One of the jaws or the fleshy covering of a jaw; -- commonly in the plural, and used of animals, and colloquially of human beings.
(n.) One of the jaws or cheeks of a vise, etc.
(n.) A buyer; a chapman.
(n.) A man or boy; a youth; a fellow.
(v. i.) To bargain; to buy.
Example Sentences:
(1) For this, different detergents such as Triton X-100, CHAPS and n-octyl beta-D glucopyranoside were tested at various concentrations, durations and temperatures of incubation.
(2) At detergent concentrations above their critical micelle concentrations, C12E8 was also much more effective than CHAPS, suggesting that micelles are not involved.
(3) That’s plain wrong, has been for decades, and a clever chap like Nelson should know it.
(4) End-on views of G on virus clearly showed triangles consisting of three dots indicating the trimeric nature of native G. End-on views of CHAPS-isolated G showed very similar triangles confirming that, using this detergent, G was solubilized in its native trimeric structure.
(5) Previous investigations (El Mestikawy et al., J Neurochem 51: 1031-1040, 1988) have shown that 5-HT1A binding sites (R[5-HT1A]) solubilized by CHAPS from rat hippocampal membranes can be modulated by guanine nucleotides, as expected from their solubilization together with associated G regulatory proteins (G).
(6) Initially, peripheral polypeptides were removed from apically enriched vesicles by washing with alkaline buffer (pH 10.8) containing 2 mM CHAPS.
(7) The enzymes could be solubilized from the membrane fractions using CHAPS, and the detergent-soluble activity partially restored by addition of phospholipids.
(8) Furthermore, the effects of detergents other than CHAPS on hydrodynamic parameters and on [3H]TCDD binding to the receptor were studied.
(9) Cation exchange chromatography on carboxymethylcellulose-Sephadex with a starting buffer of pH 5 containing 2 mM CHAPS plus 20 mM beta-OG, followed by a pH 8 buffer, showed a very small OD peak at the void volume (P) and a second peak with about 95% of the protein (E).
(10) The binding of CHAPS to the SynChropak Propyl stationary phase and its effects on retention were found to be readily reversible.
(11) Leukotriene C4 (LTC4) synthase was solubilized from the microsomes of guinea-pig lung by the new procedures of a combination of 3-[3-cholamidopropyl)dimethylammonio)-1-propanesulfonate (CHAPS), digitonin and KCl.
(12) These treatments also caused an altered distribution of phosphorylated integrin between the CHAPS soluble and insoluble fractions.
(13) The ryanodine receptor protein of sheep cardiac muscle sarcoplasmic reticulum membranes functions as a ligand-regulated ion channel following solubilization with the zwitterionic detergent CHAPS (3-[(3-cholamidopropyl)-dimethylammonio]-1- propane sulphonate); purification by density gradient centrifugation, reconstitution into proteo-liposomes and incorporation into planar phospholipid bilayers.
(14) The chap who assessed my brother was a physiotherapist,” she said.
(15) The augmentation of tone was endothelium-dependent as it did not occur following functional destruction of the endothelium by perfusion of the vascular bed with the detergent CHAPS (0.3%) for 150s.
(16) Isoelectric focusing in 2% 3-[(3-cholamidopropyl)dimethylammonio]-1-propanesulfonate (CHAPS) without urea gives good results as does 2% Nonidet-P40 with 8 M urea.
(17) Sodium nitroprusside was approximately 200 times less potent than acetylcholine in the presence of the endothelium and was the only vasorelaxant to be active after destruction of the endothelium by perfusion with 0.3% CHAPS; in the absence of the endothelium it was 3.7 times more potent as a vasodilator than in its presence.
(18) Among three detergents tested, CHAPS is the best in preserving hormonal binding affinity and specificity.
(19) In addition, the 44% peak became increasingly resistant to the inhibitory effect of CHAPS.
(20) Optimal yield was obtained by pretreatment of whole M. pneumoniae cells with buffer containing 1% Chaps and subsequent extraction with octylglucosid at a detergent to protein ratio of 5 and at octylglycoside concentrations between 1.5 and 2%.