(a.) Of great bulk or dimensions; of great size; large; thick; massive; as, bulky volumes.
Example Sentences:
(1) Survival was independent of the type of clinical presentation and protocol employed but was correlated with the stage (P less than 0.0005), symptoms (P less than 0.025), bulky disease (P less than 0.025) and bone marrow involvement (P less than 0.025).
(2) In Stage III unilateral nonbulky tumors, the pelvic failure rate was 28% compared with 45% to 50% for unilateral bulky lesions (P = 0.002).
(3) The individual micelles are relatively flat, ring-shaped structures, the center offering space for one of the two bulky sugar chains of the saponins.
(4) We describe the case of a 44 year old woman affected by gastric cancer, who only 10 months after such diagnosis and subsequent total gastrectomy, came to our observation with ascites and bulky peritoneal involvement.
(5) The estrogen receptor seems to have a moderate tolerance for bulky substituents: All of the halogen and halomethyl substituents bind with an affinity at least 50% that of estradiol; in the three atom alkyl series, the affinity declined markedly from propargyl (44%) and allyl (38%) to propyl (5%), suggestive of detailed steric constraints or a preference for unsaturation.
(6) Thorough bilateral lymphadenectomy can still be performed, but this technique avoids the principal morbidity of this operation except in some patients with bulky disease.
(7) Mammalian tissue DNA has recently been found, via 32P postlabeling, to contain complex profiles of age-dependent bulky carcinogen adductlike covalent modifications, which have been termed I-compounds, referring to their apparent indigenous origin without exposure to exogenous carcinogens.
(8) All of eight patients had relief from bulky intra-abdominal tumors.
(9) The amino-oligopeptidase of the intestinal brush border possesses high specificity for oligopeptides having bulky side chains and is a candidate for a crucial role in the overall assimilation of dietary protein.
(10) Induction with multiagent chemotherapy and radiotherapy to bulky disease-bearing areas (peripheral lymph nodes and mediastinum) was followed by consolidation, CNS prophylaxis, and cyclical remission maintenance therapy.
(11) The staples of the poor consisted of one or two bulky carbohydrate meals (derivatives of different species of cocoyam, cassava, yam and maize) eaten with vegetable soup in palm oil, melon seeds, snail, occasional meat and fish.
(12) In addition, the enzyme exhibits pronounced secondary specificity for a bulky residue, preferentially phenylalanine, in position P2 of substrates.
(13) The safety and efficacy of two devices in producing elevated temperatures in bulky deep tumours was evaluated in 11 patients with 12 tumours.
(14) An individualized approach is warranted, especially when there is an isolated bulky lesion involving the chest wall.
(15) (5) In a recent study of 23 patients undergoing resection of residual nonseminomatous testicular cancer after intensive chemotherapy, 21 had either teratoma in primary tumor or bulky metastatic disease.
(16) Abdominal findings are also similar for the two diseases, with the most common lesions appearing as low attenuation, hypoechoic masses in the solid abdominal organs; ulcerating nodular or diffusely infiltrating bowel lesions; and bulky retroperitoneal, mesenteric, or omental adenopathy.
(17) Biodistribution, imaging, and autoradiographic studies were performed in nude mice transplanted with four different human tumor cell lines to demonstrate the binding of radiolabeled antinuclear monoclonal antibodies within bulky tumors containing necrotic lesions.
(18) One hundred percent concordance between bilateral bulky parametrial involvement and positive pretreatment paraaortic nodes occurred in clinical stage IIIB and IVA patients with metastatic relapse.
(19) Study 1 concerned 667 patients treated in the period 1971-1979 without special measures for mediastinal bulky disease and with four-drug chemotherapy regimens (MOPP, COPP, ABVD) for stage B or IV.
(20) One hundred thirteen were treated at presentation with short courses of chemotherapy, most often with single-agent chlorambucil for bulky stage II and stages III and IV disease.
Cog
Definition:
(v. t.) To seduce, or draw away, by adulation, artifice, or falsehood; to wheedle; to cozen; to cheat.
(v. t.) To obtrude or thrust in, by falsehood or deception; as, to cog in a word; to palm off.
(v. i.) To deceive; to cheat; to play false; to lie; to wheedle; to cajole.
(n.) A trick or deception; a falsehood.
(n.) A tooth, cam, or catch for imparting or receiving motion, as on a gear wheel, or a lifter or wiper on a shaft; originally, a separate piece of wood set in a mortise in the face of a wheel.
(n.) A kind of tenon on the end of a joist, received into a notch in a bearing timber, and resting flush with its upper surface.
(n.) A tenon in a scarf joint; a coak.
(n.) One of the rough pillars of stone or coal left to support the roof of a mine.
(v. t.) To furnish with a cog or cogs.
(n.) A small fishing boat.
Example Sentences:
(1) Photograph: Polish Government Despite his clear-eyed approach to the looted artworks, Wächter maintains that his father was an unwilling cog in the Nazi killing machine, a position that has won him many critics.
(2) Radioimmunoassays carried out on acidic extracts of the same organs confirm the molecular results and lead us to conclude to the presence of substances strongly related to MK in the ovotestis as well as in the circumoesophageal ganglia (COG), and to ascertain that the MK-positive tentacular collar cells do not contain authentic MK.
(3) Recombination at his-3 in Neurospora crassa is thought to be initiated through a site designated cog which lies in the his-3 to ad-3 interval of linkage group I. Fragments of the his-3 gene were used to transform various his-3 mutant alleles to prototrophy in order to link the genetic map to the nucleotide sequence.
(4) On the other hand, the patient was noticed lethargic and showed parkinsonism i.e., rest tremor, cog-wheel rigidity, and hypokinesia.
(5) But this larger-than-life character was only a small cog in Fifa’s global money-making machine and the FBI successfully persuaded him to wear a wire tap and rat on his fellow officials – in a classic law-enforcement sting usually directed at mobsters.
(6) This protein was not detected in surface protein preparations of class 1 COG- mutants.
(7) It added: “A review of declarations of interest confirmed the CoG did not disclose these on the [2014] annual declaration.” In a letter dated 8 March, the government’s Education Funding Agency said there had been “serious breaches of the academies financial handbook, including serious concerns about financial management, control and governance”.
(8) We drive to the seafront, where two fishermen are toiling to the rear of the beach, turning cogs that wind a rope attached to their boat to tug it in from the sea over wooden planks.
(9) Selection for spontaneously occurring Cog- mutants gave rise to two phenotypic classes of mutants.
(10) You take a train from Interlaken to Wilderswil and then the cog railway to Schynige Platte at 2,000m for breakfast with spectacular views of the Eiger, Mönch and Jungfrau.
(11) COG in combination with subsequent behavioral hearing screening was a sensitive strategy for detecting significant hearing loss: only one child was missed with this combination.
(12) The Spurs had a 11-point lead at one point here, James wasn't scoring, Wade had more turnover than points and Rashard Lewis was the biggest offensive cog.
(13) The helices are packed in such a way as to be embedded in each other as cog-wheels.
(14) These findings are confirmed by the COG study of prolonged 5-FU which shows prolongation of disease-free survival of borderline statistical significance for Dukes' C colon (P = 0.051) + rectum (P = 0.016).
(15) Although headache-index comparisons of the two active treatments showed no advantage for adding cognitive therapy to PMR, a measure of clinically significant change showed a trend for PMR + Cog to be superior to PMR alone.
(16) A total of 270 patients with metastatic malignant melanoma were entered into a randomized chemotherapy study conducted by the Central Oncology Group (COG) over a period of 2 years (COG protocol No.
(17) Doctors do not work in a void – we are part of a team, and every part of that team is a necessary cog in the machine.
(18) I would describe my role as a small cog in the gears.
(19) The Cards DH will be another important bat, Allen Craig, one of four Cardinals to hit over .300 this season, but a cog that missed the first two Cardinals postseason series with foot issues - this also turned out just fine for the Cardinals.
(20) Five months after head injury, when he was first admitted to us, he was stable with signs of oligokinesia, katatonic posture, speechlessness, rigid muscle tones and positive cog-wheel phenomenon.