(a.) Of great bulk or dimensions; of great size; large; thick; massive; as, bulky volumes.
Example Sentences:
(1) Survival was independent of the type of clinical presentation and protocol employed but was correlated with the stage (P less than 0.0005), symptoms (P less than 0.025), bulky disease (P less than 0.025) and bone marrow involvement (P less than 0.025).
(2) In Stage III unilateral nonbulky tumors, the pelvic failure rate was 28% compared with 45% to 50% for unilateral bulky lesions (P = 0.002).
(3) The individual micelles are relatively flat, ring-shaped structures, the center offering space for one of the two bulky sugar chains of the saponins.
(4) We describe the case of a 44 year old woman affected by gastric cancer, who only 10 months after such diagnosis and subsequent total gastrectomy, came to our observation with ascites and bulky peritoneal involvement.
(5) The estrogen receptor seems to have a moderate tolerance for bulky substituents: All of the halogen and halomethyl substituents bind with an affinity at least 50% that of estradiol; in the three atom alkyl series, the affinity declined markedly from propargyl (44%) and allyl (38%) to propyl (5%), suggestive of detailed steric constraints or a preference for unsaturation.
(6) Thorough bilateral lymphadenectomy can still be performed, but this technique avoids the principal morbidity of this operation except in some patients with bulky disease.
(7) Mammalian tissue DNA has recently been found, via 32P postlabeling, to contain complex profiles of age-dependent bulky carcinogen adductlike covalent modifications, which have been termed I-compounds, referring to their apparent indigenous origin without exposure to exogenous carcinogens.
(8) All of eight patients had relief from bulky intra-abdominal tumors.
(9) The amino-oligopeptidase of the intestinal brush border possesses high specificity for oligopeptides having bulky side chains and is a candidate for a crucial role in the overall assimilation of dietary protein.
(10) Induction with multiagent chemotherapy and radiotherapy to bulky disease-bearing areas (peripheral lymph nodes and mediastinum) was followed by consolidation, CNS prophylaxis, and cyclical remission maintenance therapy.
(11) The staples of the poor consisted of one or two bulky carbohydrate meals (derivatives of different species of cocoyam, cassava, yam and maize) eaten with vegetable soup in palm oil, melon seeds, snail, occasional meat and fish.
(12) In addition, the enzyme exhibits pronounced secondary specificity for a bulky residue, preferentially phenylalanine, in position P2 of substrates.
(13) The safety and efficacy of two devices in producing elevated temperatures in bulky deep tumours was evaluated in 11 patients with 12 tumours.
(14) An individualized approach is warranted, especially when there is an isolated bulky lesion involving the chest wall.
(15) (5) In a recent study of 23 patients undergoing resection of residual nonseminomatous testicular cancer after intensive chemotherapy, 21 had either teratoma in primary tumor or bulky metastatic disease.
(16) Abdominal findings are also similar for the two diseases, with the most common lesions appearing as low attenuation, hypoechoic masses in the solid abdominal organs; ulcerating nodular or diffusely infiltrating bowel lesions; and bulky retroperitoneal, mesenteric, or omental adenopathy.
(17) Biodistribution, imaging, and autoradiographic studies were performed in nude mice transplanted with four different human tumor cell lines to demonstrate the binding of radiolabeled antinuclear monoclonal antibodies within bulky tumors containing necrotic lesions.
(18) One hundred percent concordance between bilateral bulky parametrial involvement and positive pretreatment paraaortic nodes occurred in clinical stage IIIB and IVA patients with metastatic relapse.
(19) Study 1 concerned 667 patients treated in the period 1971-1979 without special measures for mediastinal bulky disease and with four-drug chemotherapy regimens (MOPP, COPP, ABVD) for stage B or IV.
(20) One hundred thirteen were treated at presentation with short courses of chemotherapy, most often with single-agent chlorambucil for bulky stage II and stages III and IV disease.
Hefty
Definition:
(a.) Moderately heavy.
Example Sentences:
(1) Childcare carves out a hefty third of household income for one in three families, overshadowing mortgage repayments as the biggest family expenditure .
(2) There is, of course, a place for regulatory vigilance, for forcing entire institutions to clean up after themselves by paying hefty fines, and weeding out bad practices.
(3) She is now suing the French statesman in a civil court, which could result in a hefty damages award.
(4) The last time I visited they were rollerblading and after plenty of assistance managing the straps and buckles on the hefty skates, I took to the floor.
(5) But it had at its disposal a hefty deterrent: forgery was a capital offence between 1697 and 1832.
(6) If he makes the move from NYPD commissioner to Homeland Security secretary, Kelly will carry with him to Washington some very hefty baggage.
(7) Tory hedge fund and multimillionaire donors will face no similar restrictions, leaving boards free to write hefty cheques backing the Tory party.
(8) In a hard-hitting report on the countries facing macroeconomic imbalances, such as overvalued housing markets or hefty government debts, the European commission identified a total of 13 member states – including France, the Netherlands and Belgium – which it said should take urgent action to restore the health of their economies.
(9) Nine months later, the details of the scheme are yet to be agreed and Lloyds is determined to escape paying a hefty premium for the government to insure its toxic assets because it believes its losses have peaked.
(10) Pick it up and it is a surprisingly hefty bit of kit.
(11) A ustralians are routinely being told that hefty mining taxes would hinder the country’s largest exports of coal and iron ore.
(12) Oxfam's Lucy Brinicombe is blogging for the Guardian from Cancún, and here's a bit of her first post : There's an air of uncertainty here, of controlled hope mixed with a hefty dose of pragmatism compared with the heady days before last year's UN climate talks in Copenhagen, where a deadline to secure a fair, safe and legally binding climate deal came – and went.
(13) Averaged projections of the complex resemble those found for the purified PSI reaction centre after reconstitution (Ford, R.C, Hefti, A. and Engel, A.
(14) Linguistic trespassers will be prosecuted with a hefty fine.
(15) For those who like verisimilitude in their faux fags there are disposables – the hefty but effective Ten Motives or the petite, feminine NJOY – and rechargeable kits complete with USB chargers and cartridges from the likes of E-Lites, Halo and Skycig.
(16) It's probably just a fire in one of the townships.” Following Torino, Seoul and Helsinki, Cape Town is the fourth city to be awarded the title of World Design Capital, an accolade bestowed by the Montreal-based International Council for Societies of Industrial Design , which charges a hefty fee to honour a different city with its logo each year.
(17) It was certainly his best moment for the north London club after he missed a large portion of last season through injury and failed to live up to his hefty transfer fee.
(18) In animals kept on a diet with caseine the proportion of the heterohemagglutinines production and of specific antibodies had a reciprocal character, which manifested itself in a hefty depression of the agglutinines biosynthesis to sheep erythrocytes with an accruing titres of antidiphtherial antibodies.
(19) The organisers said the next generation would be more evenly split as a hefty 70% of the "ones to watch" (with just three to five years experience) were women.
(20) While small stuffed birds used to dangle from rear view mirrors – the Maltese version of fluffy dice – such displays are now rare and hunters can face hefty fines of up to €5,000 (£3,600) and jail if they are caught killing protected species.