(a.) Of great bulk or dimensions; of great size; large; thick; massive; as, bulky volumes.
Example Sentences:
(1) Survival was independent of the type of clinical presentation and protocol employed but was correlated with the stage (P less than 0.0005), symptoms (P less than 0.025), bulky disease (P less than 0.025) and bone marrow involvement (P less than 0.025).
(2) In Stage III unilateral nonbulky tumors, the pelvic failure rate was 28% compared with 45% to 50% for unilateral bulky lesions (P = 0.002).
(3) The individual micelles are relatively flat, ring-shaped structures, the center offering space for one of the two bulky sugar chains of the saponins.
(4) We describe the case of a 44 year old woman affected by gastric cancer, who only 10 months after such diagnosis and subsequent total gastrectomy, came to our observation with ascites and bulky peritoneal involvement.
(5) The estrogen receptor seems to have a moderate tolerance for bulky substituents: All of the halogen and halomethyl substituents bind with an affinity at least 50% that of estradiol; in the three atom alkyl series, the affinity declined markedly from propargyl (44%) and allyl (38%) to propyl (5%), suggestive of detailed steric constraints or a preference for unsaturation.
(6) Thorough bilateral lymphadenectomy can still be performed, but this technique avoids the principal morbidity of this operation except in some patients with bulky disease.
(7) Mammalian tissue DNA has recently been found, via 32P postlabeling, to contain complex profiles of age-dependent bulky carcinogen adductlike covalent modifications, which have been termed I-compounds, referring to their apparent indigenous origin without exposure to exogenous carcinogens.
(8) All of eight patients had relief from bulky intra-abdominal tumors.
(9) The amino-oligopeptidase of the intestinal brush border possesses high specificity for oligopeptides having bulky side chains and is a candidate for a crucial role in the overall assimilation of dietary protein.
(10) Induction with multiagent chemotherapy and radiotherapy to bulky disease-bearing areas (peripheral lymph nodes and mediastinum) was followed by consolidation, CNS prophylaxis, and cyclical remission maintenance therapy.
(11) The staples of the poor consisted of one or two bulky carbohydrate meals (derivatives of different species of cocoyam, cassava, yam and maize) eaten with vegetable soup in palm oil, melon seeds, snail, occasional meat and fish.
(12) In addition, the enzyme exhibits pronounced secondary specificity for a bulky residue, preferentially phenylalanine, in position P2 of substrates.
(13) The safety and efficacy of two devices in producing elevated temperatures in bulky deep tumours was evaluated in 11 patients with 12 tumours.
(14) An individualized approach is warranted, especially when there is an isolated bulky lesion involving the chest wall.
(15) (5) In a recent study of 23 patients undergoing resection of residual nonseminomatous testicular cancer after intensive chemotherapy, 21 had either teratoma in primary tumor or bulky metastatic disease.
(16) Abdominal findings are also similar for the two diseases, with the most common lesions appearing as low attenuation, hypoechoic masses in the solid abdominal organs; ulcerating nodular or diffusely infiltrating bowel lesions; and bulky retroperitoneal, mesenteric, or omental adenopathy.
(17) Biodistribution, imaging, and autoradiographic studies were performed in nude mice transplanted with four different human tumor cell lines to demonstrate the binding of radiolabeled antinuclear monoclonal antibodies within bulky tumors containing necrotic lesions.
(18) One hundred percent concordance between bilateral bulky parametrial involvement and positive pretreatment paraaortic nodes occurred in clinical stage IIIB and IVA patients with metastatic relapse.
(19) Study 1 concerned 667 patients treated in the period 1971-1979 without special measures for mediastinal bulky disease and with four-drug chemotherapy regimens (MOPP, COPP, ABVD) for stage B or IV.
(20) One hundred thirteen were treated at presentation with short courses of chemotherapy, most often with single-agent chlorambucil for bulky stage II and stages III and IV disease.
Immense
Definition:
(a.) Immeasurable; unlimited. In commonest use: Very great; vast; huge.
Example Sentences:
(1) Immense amounts of data about cancer-associated chromosome aberrations have been collected during the last 10 years, and the systematic evaluation of these data has disclosed a number of correlations between chromosome change and neoplastic disease.
(2) "It's immensely frustrating and I've got to the point now where I can't do internships," he said.
(3) The referendum vote has immense political implications but no direct legal effect.
(4) Resentment towards the political elite, the widening gap between the immensely rich and the poor, the deteriorating social security system, the collapse in oil prices and what Forbes has called "a stampede" of investors out of Russia – an outflow of $42bn in the first four months of 2012 – means the economy is flagging.
(5) The strain and expense of all these moves has been immense.
(6) These questions are the points of collision of two immensely important spheres of interest in our everyday life.
(7) It's the first in our planet's history where one species - ours - has Earth's future in its hands, and could jeopardise not only itself, but life's immense potential.
(8) I would urge her to follow the example of Elizabeth I, who, on appointing as her chief minister Sir William Cecil, said of him: “This opinion I have of you: that whatever you know my personal opinion to be, you will give me advice that is best for the realm.” Valerie Crews Beckenham, Kent • Another immensely qualified person loses their job for not being optimistic enough about Brexit.
(9) After 14 years of great lovemaking, an erection causes him immense pain and has terminated our sex life.
(10) Despite the "immense challenges" which Yves Mersch cited today , BNP reckons the ECB will have to take unconventional action to fight off weak inflation and to stimulate growth.
(11) It may be just as well that Hugh Grant fervently believes a film succeeds on its qualities, not on publicity about its stars, because he did his tabloid reputation as a heartless, feather-brained Lothario immense harm in the process of delivering damning testimony on phone-hacking to the Leveson inquiry on Monday.
(12) Immense occupancy and porta hepatis proximity of the cysts were triggers for developing jaundice.
(13) An immensely cerebral man, who trained himself to need only six hours of sleep - believing that a woman should have seven and only a fool eight - Mishcon was not a man given to small talk, nor one who would tolerate prattle for the sake of it.
(14) During the last years of her life, Shearer wrote book reviews (not just of dance books) for the Daily and Sunday Telegraph, which were immensely readable though not celebrated for their generosity towards authors.
(15) Global policymakers know well the immense value of forests – so why have development interventions largely failed to harness the positive contributions of forested landscapes?
(16) Thanet suffers from immense shortages of housing and jobs.
(17) The kinds of skills graduates bring can be immensely valuable.
(18) At such levels, public outrage would be immense, but we are prepared to tolerate such risks from the climate because the prospects of catastrophic levels of warming are still regarded by many as remote, the study suggested, and we are poor at calculating risk.
(19) A case is reported in which an immense cranial vault was reduced as part of the rehabilitation of a patient with severe hydrocephalus who had preservation of the intellect.
(20) Meanwhile volumes two and three of The Gulag Archipelago appeared to less public acclaim than volume one, but confirmed the uniqueness and immensity of that vast enterprise.