(a.) Of great bulk or dimensions; of great size; large; thick; massive; as, bulky volumes.
Example Sentences:
(1) Survival was independent of the type of clinical presentation and protocol employed but was correlated with the stage (P less than 0.0005), symptoms (P less than 0.025), bulky disease (P less than 0.025) and bone marrow involvement (P less than 0.025).
(2) In Stage III unilateral nonbulky tumors, the pelvic failure rate was 28% compared with 45% to 50% for unilateral bulky lesions (P = 0.002).
(3) The individual micelles are relatively flat, ring-shaped structures, the center offering space for one of the two bulky sugar chains of the saponins.
(4) We describe the case of a 44 year old woman affected by gastric cancer, who only 10 months after such diagnosis and subsequent total gastrectomy, came to our observation with ascites and bulky peritoneal involvement.
(5) The estrogen receptor seems to have a moderate tolerance for bulky substituents: All of the halogen and halomethyl substituents bind with an affinity at least 50% that of estradiol; in the three atom alkyl series, the affinity declined markedly from propargyl (44%) and allyl (38%) to propyl (5%), suggestive of detailed steric constraints or a preference for unsaturation.
(6) Thorough bilateral lymphadenectomy can still be performed, but this technique avoids the principal morbidity of this operation except in some patients with bulky disease.
(7) Mammalian tissue DNA has recently been found, via 32P postlabeling, to contain complex profiles of age-dependent bulky carcinogen adductlike covalent modifications, which have been termed I-compounds, referring to their apparent indigenous origin without exposure to exogenous carcinogens.
(8) All of eight patients had relief from bulky intra-abdominal tumors.
(9) The amino-oligopeptidase of the intestinal brush border possesses high specificity for oligopeptides having bulky side chains and is a candidate for a crucial role in the overall assimilation of dietary protein.
(10) Induction with multiagent chemotherapy and radiotherapy to bulky disease-bearing areas (peripheral lymph nodes and mediastinum) was followed by consolidation, CNS prophylaxis, and cyclical remission maintenance therapy.
(11) The staples of the poor consisted of one or two bulky carbohydrate meals (derivatives of different species of cocoyam, cassava, yam and maize) eaten with vegetable soup in palm oil, melon seeds, snail, occasional meat and fish.
(12) In addition, the enzyme exhibits pronounced secondary specificity for a bulky residue, preferentially phenylalanine, in position P2 of substrates.
(13) The safety and efficacy of two devices in producing elevated temperatures in bulky deep tumours was evaluated in 11 patients with 12 tumours.
(14) An individualized approach is warranted, especially when there is an isolated bulky lesion involving the chest wall.
(15) (5) In a recent study of 23 patients undergoing resection of residual nonseminomatous testicular cancer after intensive chemotherapy, 21 had either teratoma in primary tumor or bulky metastatic disease.
(16) Abdominal findings are also similar for the two diseases, with the most common lesions appearing as low attenuation, hypoechoic masses in the solid abdominal organs; ulcerating nodular or diffusely infiltrating bowel lesions; and bulky retroperitoneal, mesenteric, or omental adenopathy.
(17) Biodistribution, imaging, and autoradiographic studies were performed in nude mice transplanted with four different human tumor cell lines to demonstrate the binding of radiolabeled antinuclear monoclonal antibodies within bulky tumors containing necrotic lesions.
(18) One hundred percent concordance between bilateral bulky parametrial involvement and positive pretreatment paraaortic nodes occurred in clinical stage IIIB and IVA patients with metastatic relapse.
(19) Study 1 concerned 667 patients treated in the period 1971-1979 without special measures for mediastinal bulky disease and with four-drug chemotherapy regimens (MOPP, COPP, ABVD) for stage B or IV.
(20) One hundred thirteen were treated at presentation with short courses of chemotherapy, most often with single-agent chlorambucil for bulky stage II and stages III and IV disease.
Ponderous
Definition:
(a.) Very heavy; weighty; as, a ponderous shield; a ponderous load; the ponderous elephant.
(a.) Important; momentous; forcible.
(a.) Heavy; dull; wanting; lightless or spirit; as, a ponderous style; a ponderous joke.
Example Sentences:
(1) It helped pay the bills and caused me to ponder on the disconnection between theory and reality.
(2) Confirmation of the striking correlation between increased urinary ammonia and lowered neonatal ponderal index may afford a simple test for the identification of nutrient-related growth retardation.
(3) For Argyle the result confirmed their relegation to League One, with the rival fans left to ponder wildly differing prospects next season.
(4) The results indicated significant negative correlations between maternal plasma zinc and albumin-bound zinc concentrations and plasma copper concentration in the third trimester of pregnancy and mid-arm circumference and ponderal index.
(5) A comparison of outcome was made between infants whose birth-weight for gestational age was below the tenth percentile and infants who had a low ponderal index from 37 weeks' gestation.
(6) Some epidemiological data have been collected, among which: the importance of ponderal overload in patients studied and the prevalence of the right joints diseases on the left one's.
(7) Nor do most of its users – as they check out the capital of Georgia or guiltily plagiarise the entry on Marx – ponder how this Eden is sustained in its spotless state of nature.
(8) Sting – a man who had split the Police to pursue a more adult-oriented career, and who would in the following year ponder such poptastic issues as how much Russians loved their children and the plight of miners – took that job in 1984, while this year it falls to Guy Garvey, who may as well just change his middle name to 6Music.
(9) The air was sampled daily by glass fiber's filters; a ponderal determination of total particulate was made; PAH was dosed by gas-chromatography and by mass spectrometry, metals was determined by atomic absorption spectrometry.
(10) In these six pairs a normal ponderal index in the lighter twin members was associated with poorer growth than a low ponderal index.
(11) The ponderal quantity of 140 S antigens and their peptide distribution are controlled in concentrated virulent and inactivated preparations proir to their being transformed into vaccines.
(12) There was still time for Saborio to try an audacious lob from distance to steal the game, but Nielsen, who'd looked ponderous in his movements all game, was able to watch this one safely over.
(13) Objective identification of infants with significant intrauterine growth retardation (IUGR) was done using the ponderal index (PI).
(14) Plasma lipid levels were significantly lower when the animals received the diets containing milk instead of the diet without milk: cholesterol, triacylglycerol, and LDL-cholesterol were reduced by 5.6, 5.8 and 10% respectively (pondered means) while HDL-cholesterol remained unaffected.
(15) I pondered the scene once or twice last week, with the news dominated by Lord Rennard and ongoing allegations of his having groped women .
(16) The mean fetal ponderal index of the controls was 8.60 (SD 0.84) and in the risk group 7.72.
(17) Correlation analysis revealed that longer average initial fixation time was associated with male sex, shorter birth length, and larger ponderal index.
(18) Manning and Snowden cannot have been the only US officials to have pondered blowing a whistle on data abuse.
(19) Ponder this as you take in mountain views through floor-to-ceiling windows or from the secluded patio.
(20) At birth, 14 normal babies had average ponderal indices, 14 were overweight for length (high ponderal index), 18 were underweight for length (low ponderal index), and 15 had short crown-heel lengths for dates and normal ponderal indices.