(a.) Of great bulk or dimensions; of great size; large; thick; massive; as, bulky volumes.
Example Sentences:
(1) Survival was independent of the type of clinical presentation and protocol employed but was correlated with the stage (P less than 0.0005), symptoms (P less than 0.025), bulky disease (P less than 0.025) and bone marrow involvement (P less than 0.025).
(2) In Stage III unilateral nonbulky tumors, the pelvic failure rate was 28% compared with 45% to 50% for unilateral bulky lesions (P = 0.002).
(3) The individual micelles are relatively flat, ring-shaped structures, the center offering space for one of the two bulky sugar chains of the saponins.
(4) We describe the case of a 44 year old woman affected by gastric cancer, who only 10 months after such diagnosis and subsequent total gastrectomy, came to our observation with ascites and bulky peritoneal involvement.
(5) The estrogen receptor seems to have a moderate tolerance for bulky substituents: All of the halogen and halomethyl substituents bind with an affinity at least 50% that of estradiol; in the three atom alkyl series, the affinity declined markedly from propargyl (44%) and allyl (38%) to propyl (5%), suggestive of detailed steric constraints or a preference for unsaturation.
(6) Thorough bilateral lymphadenectomy can still be performed, but this technique avoids the principal morbidity of this operation except in some patients with bulky disease.
(7) Mammalian tissue DNA has recently been found, via 32P postlabeling, to contain complex profiles of age-dependent bulky carcinogen adductlike covalent modifications, which have been termed I-compounds, referring to their apparent indigenous origin without exposure to exogenous carcinogens.
(8) All of eight patients had relief from bulky intra-abdominal tumors.
(9) The amino-oligopeptidase of the intestinal brush border possesses high specificity for oligopeptides having bulky side chains and is a candidate for a crucial role in the overall assimilation of dietary protein.
(10) Induction with multiagent chemotherapy and radiotherapy to bulky disease-bearing areas (peripheral lymph nodes and mediastinum) was followed by consolidation, CNS prophylaxis, and cyclical remission maintenance therapy.
(11) The staples of the poor consisted of one or two bulky carbohydrate meals (derivatives of different species of cocoyam, cassava, yam and maize) eaten with vegetable soup in palm oil, melon seeds, snail, occasional meat and fish.
(12) In addition, the enzyme exhibits pronounced secondary specificity for a bulky residue, preferentially phenylalanine, in position P2 of substrates.
(13) The safety and efficacy of two devices in producing elevated temperatures in bulky deep tumours was evaluated in 11 patients with 12 tumours.
(14) An individualized approach is warranted, especially when there is an isolated bulky lesion involving the chest wall.
(15) (5) In a recent study of 23 patients undergoing resection of residual nonseminomatous testicular cancer after intensive chemotherapy, 21 had either teratoma in primary tumor or bulky metastatic disease.
(16) Abdominal findings are also similar for the two diseases, with the most common lesions appearing as low attenuation, hypoechoic masses in the solid abdominal organs; ulcerating nodular or diffusely infiltrating bowel lesions; and bulky retroperitoneal, mesenteric, or omental adenopathy.
(17) Biodistribution, imaging, and autoradiographic studies were performed in nude mice transplanted with four different human tumor cell lines to demonstrate the binding of radiolabeled antinuclear monoclonal antibodies within bulky tumors containing necrotic lesions.
(18) One hundred percent concordance between bilateral bulky parametrial involvement and positive pretreatment paraaortic nodes occurred in clinical stage IIIB and IVA patients with metastatic relapse.
(19) Study 1 concerned 667 patients treated in the period 1971-1979 without special measures for mediastinal bulky disease and with four-drug chemotherapy regimens (MOPP, COPP, ABVD) for stage B or IV.
(20) One hundred thirteen were treated at presentation with short courses of chemotherapy, most often with single-agent chlorambucil for bulky stage II and stages III and IV disease.
(superl.) Firm; tough; materially strong; enduring; as, a stout vessel, stick, string, or cloth.
(superl.) Large; bulky; corpulent.
(n.) A strong malt liquor; strong porter.
Example Sentences:
(1) Second, Stout felt that the high mitotic rate was the best predictor of malignancy, but he recognized that some tumors, even with low rates, could metastasize.
(2) The cell bodies are usually between 8 and 10 mu in diameter and have dividing pseudopodial processes which may be broad or narrow, flat or stout, smooth or varicosed.
(3) The Lib Dems and Labour, after frantic consultations, announced they would table alternative amendments to introduce an element of statute and ensure the new press regulatory body was free from industry interference – two issues that the majority of newspaper proprietors have stoutly opposed.
(4) It also highlights law professor Lynn Stout’s recent book, The Shareholder Value Myth .
(5) Stout – even the name is robust: broad-mouthed and curtly clipped at the end.
(6) Tune into BBC1 on Sunday morning and you will find the corporation complicit in Marr's convalescent strategy of stout denial.
(7) Against my will I had to keep watching those two black companions who persistently marked out our movements ahead of us, like walking silhouettes, and it gave me – our feelings are sometimes so childish – a certain reassurance to see that my shadow was longer, slimmer, I almost said "better-looking", than the short, stout shadow of my companion.
(8) A stout man with close-cropped hair, Jones was dressed in denim, his temples soaked with sweat.
(9) Heat the sugar, cocoa powder, double cream, stout and salt in a small pan until scalding.
(10) Aside from history enthusiasts and couples seeking privacy from the crowded city, few enter the red sandstone gate between the fort’s stout bastions.
(11) Chocolate stout pudding (above) Admittedly, with summer creeping in and temperatures rising, it's hardly pudding season.But I'm a firm believer in the restorative powers of stodge, and I'd hate for the pleasures of pudding – steamed sponges, sticky toffee, spotted dick and custard – to be out of bounds for part of the year.
(12) This investigation is a replication and extension of an earlier study by Stout, Holmes, and Rothstein (1977) of the predoctoral clinical psychology intern graduates at the William S. Hall Psychiatric Institute.
(13) The differential diagnosis of the morphological substrate is discussed and the preference of the termination introduced by Stout and Lattes is established.
(14) The pyriform cells had a short stem from which extended 4-5 stout dendrites, while the fusiform cells extended similar dendrites from the soma.
(15) All these characters are fictionalised, but they are based on real people: Frank Stokes is modelled on George Stout ; Campbell on Robert K. Posey ; Garfield on Walker Hancock ; Granger on James Rorimer .
(16) There’s nothing flash or trendy about it, just an immaculate, traditionally brewed, higher alcohol stout; a reminder that, for all the cool stuff going on in the beer world today, you can always learn from the past.
(17) At the pub on the island there was a concertina-player and we got the feeling – fuelled by pints of rich dark stout – that we were being absorbed into a community.
(18) The stout-candied air, high beams and heavy pews are reminiscent of church-scale pubs on Galway’s Quay Street, but the beams are hung with Arthurian standards.
(19) Cysteines 358, 421, and 424 are ligands to the Fe-S cluster in the inactive [3Fe-4S] (Robbins, A. H., and Stout, C. D. (1989) Proteins 5, 289-312) and active [4Fe-4S] (Robbins, A. H., and Stout, C. D. (1989) Proc.
(20) Solid and traditional, all acres of dark wood and stained glass, it prides itself on its list of around 18 mainly bottled Irish beers from such breweries as Kinsale, Hilden, Station Works, Farmageddon, Clever Man (look out for its Ejector Seat turf-smoked stout) and Hercules.