(n.) That which is borne with labor or difficulty; that which is grievous, wearisome, or oppressive.
(n.) The capacity of a vessel, or the weight of cargo that she will carry; as, a ship of a hundred tons burden.
(n.) The tops or heads of stream-work which lie over the stream of tin.
(n.) The proportion of ore and flux to fuel, in the charge of a blast furnace.
(n.) A fixed quantity of certain commodities; as, a burden of gad steel, 120 pounds.
(n.) A birth.
(v. t.) To encumber with weight (literal or figurative); to lay a heavy load upon; to load.
(v. t.) To oppress with anything grievous or trying; to overload; as, to burden a nation with taxes.
(v. t.) To impose, as a load or burden; to lay or place as a burden (something heavy or objectionable).
(n.) The verse repeated in a song, or the return of the theme at the end of each stanza; the chorus; refrain. Hence: That which is often repeated or which is dwelt upon; the main topic; as, the burden of a prayer.
(n.) The drone of a bagpipe.
(n.) A club.
Example Sentences:
(1) Senator Bernie Sanders of Vermont, who is also seeking the Democratic presidential nomination, recently proposed a bill that would ease the financial burden of prescription drugs on elderly Americans by allowing Medicare, the national social health insurance program, to negotiate with the pharmaceutical companies to keep prices down.
(2) Finally, before the advent of the third-party payment, operations were avoided because of the financial burden.
(3) However, civil society groups have raised concerns about the ethics of providing ‘climate loans’ which increase the country’s debt burden.
(4) The parasites were highly aggregated within the study community, with most people harbouring low burdens while a few individuals harboured very heavy burdens.
(5) Economic burdens for postmarketing research should be shared jointly by the research-oriented and generic drug companies.
(6) There is general agreement that suicides are likely to be undercounted, both for structural reasons (the burden-of-proof issue, the requirement that the coroner or medical examiner suspect the possibility of suicide) and for sociocultural reasons.
(7) The art Kennard produced formed the basis of his career, as he recounted later: “I studied as a painter, but after the events of 1968 I began to look for a form of expression that could bring art and politics together to a wider audience … I found that photography wasn’t as burdened with similar art historical associations.” The result was his STOP montage series.
(8) The analysis indicated a high cost burden for families in all disease categories studied, although a lack of uniformity in data presentation and in the variables studied prevented specific generalizations to be made about the numbers or characteristics of families with high costs.
(9) "Public servants did nothing to cause the slump but are being asked to bear an unfair share of the burden.
(10) The irony of this type of self-manipulation is that ultimately the child, or adult, finds himself again burdened by impotence, though it is the impotence of guilt rather than that of shame.
(11) The aim of the study was to find whether treatment would result in an improvement of cognition, of functioning in daily life, decrease of behavioural disturbances, and decrease in burden experienced by the carers.
(12) Lymph proliferative disorders with a high mitotic rate, and large tumor burden, regardless of histologic features, should be treated prophylactically against tumor lysis if regrowth between cycles occurs.
(13) These data indicate that, compared with animals at sea level, animals at altitude have an increased body burden of COHb and will attain the COHb level associated with the National Ambient Air Quality Standard for CO more quickly when breathing CO.
(14) Macro-epidemiology is concerned with the absolute and relative contributions of particular causes or diseases to the overall burden of ill-health in a population.
(15) Communicable diseases represent a considerable burden in terms of suffering and costs.
(16) This is indirect evidence suggesting that mercury from dental amalgam fillings may contribute to the body burden of mercury in the brain.
(17) The gender-specific kinship relationship of patients and their care providers has not generally been investigated in studies of caregiver burden and well-being.
(18) In predicting response to therapy, poor prognostic factors included large tumor burdens, advanced disease stage, and chemotherapy-resistant tumors.
(19) Radical postoperative irradiation (A) is burdened by 3 serious complications and a considerably higher amount of complaints.
(20) MMC and 5-FU did not show significant activity against large tumor burden, while a relatively good activity was detected in patients with minimal disease.
Channel
Definition:
(n.) The hollow bed where a stream of water runs or may run.
(n.) The deeper part of a river, harbor, strait, etc., where the main current flows, or which affords the best and safest passage for vessels.
(n.) A strait, or narrow sea, between two portions of lands; as, the British Channel.
(n.) That through which anything passes; means of passing, conveying, or transmitting; as, the news was conveyed to us by different channels.
(n.) A gutter; a groove, as in a fluted column.
(n.) Flat ledges of heavy plank bolted edgewise to the outside of a vessel, to increase the spread of the shrouds and carry them clear of the bulwarks.
(v. t.) To form a channel in; to cut or wear a channel or channels in; to groove.
(v. t.) To course through or over, as in a channel.
Example Sentences:
(1) These channels may, at least in some cases, be responsible for the generation of pacemaker depolarizations, thereby regulating firing behaviour.
(2) The influence of the various concepts for the induction of lateral structure formation in lipid membranes on integral functional units like ionophores is demonstrated by analysing the single channel current fluctuations of gramicidin in bimolecular lipid membranes.
(3) RNAs encoding a wild-type (RBK1) and a mutant (RBK1(Y379V,V381T); RBK1*) subunit of voltage-dependent potassium channels were injected into Xenopus oocytes.
(4) The dramas are part of the BBC2 controller Janice Hadlow's plans for her "unashamedly intelligent" channel over the coming months.
(5) This was unlike the action of the calcium channel blocker, cadmium, which reduced the calcium action potential and the a.h.p.
(6) Circuitry has been developed to feed the output of an ear densitogram pickup into one channel of a two-channel Holter monitor.
(7) It is concluded the decrease in cellular volume associated with substitution of serosal gluconate for Cl results in a loss of highly specific Ba2+-sensitive K+ conductance channels from the basolateral plasma membrane.
(8) Stimulation of atrial H1-receptors is suggested to directly cause an increase in Ca-channel conductance independent of intracellular cAMP content.
(9) Similarly, 50 microM D-600, a Ca+2 channel antagonist, significantly (P less than 0.01) reduced basal and 5-HETE-induced PRL release.
(10) The purpose of the present study was to analyze the effects of cromakalim (BRL 34915), a potent drug from a new class of drugs characterized as "K+ channel openers", on the electrical activity of human skeletal muscle.
(11) This promotion of repetitive activity by the introduction of additional potassium channels occurred up to an "optimal" value beyond which a further increase in paranodal potassium permeability narrowed the range of currents with a repetitive response.
(12) Channel activation persists through the process of platelet isolation and washing and is manifested in higher measured values of [Ca2+]cyt and [Ca2+]dt in the "resting state."
(13) At 100 microM-ACh the apparent open time became shorter probably due to channel blockade by ACh molecules.
(14) The effects of low doses of dihydropyridine (DHP) calcium channel antagonists nimodipine, nifedipine, (-)-R-202-791, and amlodipine, the DHP calcium channel agonist BAY K 8644 were investigated on clonic convulsions to pentylenetetrazole (PTZ) in mice.
(15) The following model is suggested: exogenous ATP interacts with a membrane receptor in the presence of Ca2+, a cascade of events occurs which mobilizes intracellular calcium, thereby increasing the cytosolic free Ca2+ concentration which consequently opens the calcium-activated K+ channels, which then leads to a change in membrane potential.
(16) SDS-PAGE analysis of the immunoprecipitates under reducing conditions revealed that the cardiac channel is mainly composed of two large polypeptides of 190 and 150 kDa, and five smaller polypeptides of 60, 55, 35, 30, and 25 kDa.
(17) In the presence of high external Cl, a component of outward current that was inhibited by the anion channel blocker diphenylamine-2-carboxylate (DPC) appeared in 70% of the cells.
(18) In vitro studies in cardiac Purkinje fibers suggested that reversal of amitriptyline-induced cardiac membrane effects by sodium bicarbonate may be attributed not only to alkalinization but also to increased in extracellular sodium concentration, diminishing the local anesthetic action of amitriptyline and resulting in less sodium channel block.
(19) The Ca2+ channel current recorded under identical conditions in rat dorsal root ganglion neurones was less sensitive to blockade by PCP (IC50, 90 microM).
(20) In voltage-clamp experiments the ion current flowing through the channels was homogeneous indicating a defined conformation and a uniform size.