(n.) That which is borne with labor or difficulty; that which is grievous, wearisome, or oppressive.
(n.) The capacity of a vessel, or the weight of cargo that she will carry; as, a ship of a hundred tons burden.
(n.) The tops or heads of stream-work which lie over the stream of tin.
(n.) The proportion of ore and flux to fuel, in the charge of a blast furnace.
(n.) A fixed quantity of certain commodities; as, a burden of gad steel, 120 pounds.
(n.) A birth.
(v. t.) To encumber with weight (literal or figurative); to lay a heavy load upon; to load.
(v. t.) To oppress with anything grievous or trying; to overload; as, to burden a nation with taxes.
(v. t.) To impose, as a load or burden; to lay or place as a burden (something heavy or objectionable).
(n.) The verse repeated in a song, or the return of the theme at the end of each stanza; the chorus; refrain. Hence: That which is often repeated or which is dwelt upon; the main topic; as, the burden of a prayer.
(n.) The drone of a bagpipe.
(n.) A club.
Example Sentences:
(1) Senator Bernie Sanders of Vermont, who is also seeking the Democratic presidential nomination, recently proposed a bill that would ease the financial burden of prescription drugs on elderly Americans by allowing Medicare, the national social health insurance program, to negotiate with the pharmaceutical companies to keep prices down.
(2) Finally, before the advent of the third-party payment, operations were avoided because of the financial burden.
(3) However, civil society groups have raised concerns about the ethics of providing ‘climate loans’ which increase the country’s debt burden.
(4) The parasites were highly aggregated within the study community, with most people harbouring low burdens while a few individuals harboured very heavy burdens.
(5) Economic burdens for postmarketing research should be shared jointly by the research-oriented and generic drug companies.
(6) There is general agreement that suicides are likely to be undercounted, both for structural reasons (the burden-of-proof issue, the requirement that the coroner or medical examiner suspect the possibility of suicide) and for sociocultural reasons.
(7) The art Kennard produced formed the basis of his career, as he recounted later: “I studied as a painter, but after the events of 1968 I began to look for a form of expression that could bring art and politics together to a wider audience … I found that photography wasn’t as burdened with similar art historical associations.” The result was his STOP montage series.
(8) The analysis indicated a high cost burden for families in all disease categories studied, although a lack of uniformity in data presentation and in the variables studied prevented specific generalizations to be made about the numbers or characteristics of families with high costs.
(9) "Public servants did nothing to cause the slump but are being asked to bear an unfair share of the burden.
(10) The irony of this type of self-manipulation is that ultimately the child, or adult, finds himself again burdened by impotence, though it is the impotence of guilt rather than that of shame.
(11) The aim of the study was to find whether treatment would result in an improvement of cognition, of functioning in daily life, decrease of behavioural disturbances, and decrease in burden experienced by the carers.
(12) Lymph proliferative disorders with a high mitotic rate, and large tumor burden, regardless of histologic features, should be treated prophylactically against tumor lysis if regrowth between cycles occurs.
(13) These data indicate that, compared with animals at sea level, animals at altitude have an increased body burden of COHb and will attain the COHb level associated with the National Ambient Air Quality Standard for CO more quickly when breathing CO.
(14) Macro-epidemiology is concerned with the absolute and relative contributions of particular causes or diseases to the overall burden of ill-health in a population.
(15) Communicable diseases represent a considerable burden in terms of suffering and costs.
(16) This is indirect evidence suggesting that mercury from dental amalgam fillings may contribute to the body burden of mercury in the brain.
(17) The gender-specific kinship relationship of patients and their care providers has not generally been investigated in studies of caregiver burden and well-being.
(18) In predicting response to therapy, poor prognostic factors included large tumor burdens, advanced disease stage, and chemotherapy-resistant tumors.
(19) Radical postoperative irradiation (A) is burdened by 3 serious complications and a considerably higher amount of complaints.
(20) MMC and 5-FU did not show significant activity against large tumor burden, while a relatively good activity was detected in patients with minimal disease.
Purge
Definition:
(v. t.) To cleanse, clear, or purify by separating and carrying off whatever is impure, heterogeneous, foreign, or superfluous.
(v. t.) To operate on as, or by means of, a cathartic medicine, or in a similar manner.
(v. t.) To clarify; to defecate, as liquors.
(v. t.) To clear of sediment, as a boiler, or of air, as a steam pipe, by driving off or permitting escape.
(v. t.) To clear from guilt, or from moral or ceremonial defilement; as, to purge one of guilt or crime.
(v. t.) To clear from accusation, or the charge of a crime or misdemeanor, as by oath or in ordeal.
(v. t.) To remove in cleansing; to deterge; to wash away; -- often followed by away.
(v. i.) To become pure, as by clarification.
(v. i.) To have or produce frequent evacuations from the intestines, as by means of a cathartic.
(v. t.) The act of purging.
(v. t.) That which purges; especially, a medicine that evacuates the intestines; a cathartic.
Example Sentences:
(1) Thus photosensitization using AISPc may be an effective method of purging marrow autografts in some cases of AML.
(2) Current investigations include the development of more effective cytoreductive regimens, use of recombinant hematopoietic growth factors, improvement of marrow purging techniques, and enhancement of cell-mediated anti-leukemic activity in patients receiving autologous marrow transplants.
(3) Direct detection of chromium in milk, using only argon as purge gas, was inferior.
(4) Indiana Indiana began to purge inactive voters in may 2014 by sending postcards to all registered voters.
(5) Sequential application of the two methods (immunorosette depletion with CD19 McAb followed by a complement lysis with CD9 and CD10 McAbs) led to superior results in causing a 4- to 5-log purging effect.
(6) Reduced caloric intake, a hallmark of both disorders, is manifested by self-induced starvation in anorexia and by binge eating and gastrointestinal purging in bulimia.
(7) Mafosfamide is presently used for the purging of bone marrow in autologous bone marrow transplantation in the treatment of acute leukemia.
(8) The two log difference in the surviving fraction of CFU-L and CFU-S after 120 min exposure to 42.5 degrees C suggests that hyperthermia ex vivo may be a suitable purging method for autologous bone marrow transplantation.
(9) There are already calls for large protests in Egypt this week demanding fair trials and retribution, as well as measures to purge former regime officials from political and economic life.
(10) Our data suggest that this new strategy shows potential for more effective ex vivo marrow purging in autologous marrow transplantation for acute lymphoblastic leukemia.
(11) In summary, laser light-induced photosensitization with MC540 has a selective cytotoxicity to leukemic cells; therefore, this procedure may be useful for purging neoplastic cells from autologous BM.
(12) Pretransplantation regimes were: total-body irradiation (TBI), 456; busulfan plus cyclophosphamide (BU-CY) 174; marrow purging with mafosfamide, 269 (corresponding to 26% of all patients in CR1 and 41% in CR2).
(13) Phase 1 studies of "in vivo purging" with a monovalent CD3 antibody (Clark et al., 1989), and also with a genetically engineered humanized IgG1 (CAMPATH-1H) (Hale et al., 1988b) suggest that these limitations can be overcome.
(14) Despite patient and disease heterogeneity, different sources of hemopoietic stem cells (allogeneic or autologous, bone marrow or blood), ex vivo purging of autografts, and different preparative regimens, some general recommendations can be made: (1) Allogeneic BMT should be reserved for patients under age 50, where transplant-related mortality can be expected not to exceed 30%; 40% will achieve CR with a 3-year relapse-free survival expectation of 70%, and (2) With autologous transplantation, low mortality under 10% and marked therapeutic benefit (greater than 30% CR, 80% overall survival at greater than 3 years) seem to be achievable mainly if performed when tumor bulk is low and standard doses of therapy are still effective.
(15) The transfusion purging leukocytes may diminish the occasions of alloimmunization.
(16) The Brotherhood's Libyan incarnation won only 10% of the vote in last year's congressional elections, but gained support with its campaign to mandate wholesale purges of Gaddafi-era officials.
(17) We feel that this system will prove valuable for monitoring ex vivo tumor removal in future clinical studies and should be considered for use in other purging trials.
(18) The quantitative determination of the efficacy of these purging methods is generally difficult.
(19) The government began aggressively purging the heads of cultural and academic institutions (a notable number of them Jewish and liberal intellectuals suspected of a “foreign” mindset) and installing in their stead true believers in the Magyar way.
(20) The result of our study in patients in second and third remission using in vitro purging of bone marrow with monoclonal antibodies PM-81 and AML2-23 are encouraging, as are the studies of purging with 4-HC.