(1) The first case was a 45-year-old cachectic man with extensive bilateral pulmonary infiltrates.
(2) Within 3 days after 5'-deoxy-5-fluorouridine was administered to cachectic mice with large tumor burdens, the wasting was immediately reversed even at doses in which there was increase or no significant reduction in tumor growth.
(3) When TPN was used in inoperable, cachectic patients (8 patients-group 3) to permit them to tolerate radiotherapy or chemotherapy, the mortality was 37.5%.
(4) Insulin administration resulted in preservation of host nitrogen, fat, potassium, sodium, and chloride in cachectic tumor-bearing rats.
(5) To explore these questions, plasma was sterilely collected and pooled from 103 terminally cachectic Fischer 344 rats implanted with an experimental sarcoma.
(6) This procedure was successfully used in two patients with nephroctic syndrom secondary to a renal amyloïdosis, who where in a cachectic state.
(7) The results are in accordance with the hypothesis that glucocorticoids are involved in the increased protein catabolism of skeletal muscles and other signs of cachectic tumor patients.
(8) The studies reported here were provoked by the observation that tumor-bearing rats become extremely cachectic and develop hypertriglyceridemia as they become hypercalcemic.
(9) Bacterial pathogens which infect pulmonary macrophages may elicit the secretion of TNF-alpha within the lungs and lead to the cachectic state associated with chronic pneumonia.
(10) A particular cachectic syndrome, the "slim disease", which is highly suggestive of AIDS in Africa, constitutes the substratum for the clinical definition for AIDS.
(11) Evidence is presented to support a role for interleukin (IL-6) as a cachectic factor in the development of cancer cachexia in this model system.
(12) We now report that the hyperlipidemic effect of TNF persists during chronic TNF administration in the absence of any cachectic effect of TNF.
(13) Increased TNF-alpha levels have been observed not only in cancer patients but also in cachectic patients with the acquired immunodeficiency syndrome (AIDS), and TNF-alpha is known to increase the expression of the human immunodeficiency virus type 1 (HIV-1) via activating its long terminal repeat (LTR).
(14) Serum cortisol and urinary excretion of vanillymandelic acid were higher, and serum insulin level tended to be lower in cachectic patients postoperatively.
(15) No cachectic effect was detected in either half of the NTB parabionts.
(16) 2) Normal human RBC were made less deformable and their membrane was made fragile by treatment with cachectic plasma from those patients, and these changes in physical properties were irreversible.
(17) The growth rate of the MAC16 tumour in cachectic animals was significantly enhanced by the hypolipidemic agent bezafibrate, while the growth rate of a histologically similar tumour, the MAC13, which grows without an effect on host body compartments was unaffected.
(18) The concentration of SAA did not correlate with the duration of AD or AD-like process although the highest values were found in cachectic AD patients confined to bed.
(19) Fistulization in the transverse colon led to a short-circulting of the small bowel and an advanced cachectic condition.
(20) Once daily NPH insulin for 5 days during cachectic decline was well tolerated (no treatment deaths), and improved median survival of TB rats randomized to insulin (15 days) compared to controls (13 days, p = 0.06).
Cachexia
Definition:
(n.) Alt. of Cachexy
Example Sentences:
(1) Two of the TNF responders subsequently died of cachexia and respiratory infection.
(2) Cachexia and septic shock, syndromes associated with chronic and acute infection, respectively, are mediated by endogenous factors.
(3) The mechanisms by which tumour growth causes anorexia and cachexia in these rats remains obscure.
(4) The findings are consistent with the hypothesis that slow continuous secretion of sublethal amounts of TNF may mediate cancer cachexia.
(5) After an average of 2--3 months an obvious cachexia as well as a steatorrhea could be observed.
(6) Factors affecting early v late weaning from ventilatory support after cardiac surgery were retrospectively compared in 15 patients with cardiac cachexia.
(7) In 1888 cretinism, myxoedema and cachexia strumipriva were attributed to thyroid insufficiency.
(8) TNF is also allied with the effects of cachexia and has been shown to be similar to, if not exactly the same as, cachectin.
(9) Human and rat normal tissues and tumours have been studied for the presence of toxic substances, possibly of importance in the development of cachexia in patients with cancer and other chronic diseases.
(10) But combined activity of TNF and IFN on the vasculature of renal cell carcinoma (JRC 11) and the suppression of cachexia related condition were detected.
(11) IL-6 transfection did not induce immunity, but induced cachexia.
(12) Inadequate growth in chronic inflammatory bowel disease is currently ascribed to inadequate nutrition and TNF alpha may contribute to this through its cachexia inducing effects.
(13) In a more applied sense, such knowledge may also provide a rational approach to controlling metabolic disease syndromes related to adipogenesis gone awry such as obesity-associated diabetes and cachexia.
(14) As the study progressed, clinical signs associated with trypanosomiasis, such as anaemia and cachexia, disappeared gradually in treated bulls.
(15) Mechanisms for the development of cancer cachexia are not well defined.
(16) These aspects of the tumour model make it useful for investigations into host-tumour competition and mechanisms of cachexia.
(17) These findings suggest that gamma-interferon may be an important mediator of cachexia in this rat tumor model.
(18) The serum factor inducing hemorrhagic necrosis of transplantable tumors [tumor necrosis factor (TNF)], and the macrophage hormone associated with cachexia in cancer and certain infectious diseases [cachectin] are known to be the same protein.
(19) However, the stimulatory influence of the tumor-bearing state may be overridden by the inhibitory effects of cachexia.
(20) To evaluate the possible role of altered glucose metabolism in malignant cachexia, metabolic parameters including total glucose turnover, glucose oxidation, and Cori cycle activity were measured in fourteen patients with metastatic carcinoma.