(1) Two of the TNF responders subsequently died of cachexia and respiratory infection.
(2) Cachexia and septic shock, syndromes associated with chronic and acute infection, respectively, are mediated by endogenous factors.
(3) The mechanisms by which tumour growth causes anorexia and cachexia in these rats remains obscure.
(4) The findings are consistent with the hypothesis that slow continuous secretion of sublethal amounts of TNF may mediate cancer cachexia.
(5) After an average of 2--3 months an obvious cachexia as well as a steatorrhea could be observed.
(6) Factors affecting early v late weaning from ventilatory support after cardiac surgery were retrospectively compared in 15 patients with cardiac cachexia.
(7) In 1888 cretinism, myxoedema and cachexia strumipriva were attributed to thyroid insufficiency.
(8) TNF is also allied with the effects of cachexia and has been shown to be similar to, if not exactly the same as, cachectin.
(9) Human and rat normal tissues and tumours have been studied for the presence of toxic substances, possibly of importance in the development of cachexia in patients with cancer and other chronic diseases.
(10) But combined activity of TNF and IFN on the vasculature of renal cell carcinoma (JRC 11) and the suppression of cachexia related condition were detected.
(11) IL-6 transfection did not induce immunity, but induced cachexia.
(12) Inadequate growth in chronic inflammatory bowel disease is currently ascribed to inadequate nutrition and TNF alpha may contribute to this through its cachexia inducing effects.
(13) In a more applied sense, such knowledge may also provide a rational approach to controlling metabolic disease syndromes related to adipogenesis gone awry such as obesity-associated diabetes and cachexia.
(14) As the study progressed, clinical signs associated with trypanosomiasis, such as anaemia and cachexia, disappeared gradually in treated bulls.
(15) Mechanisms for the development of cancer cachexia are not well defined.
(16) These aspects of the tumour model make it useful for investigations into host-tumour competition and mechanisms of cachexia.
(17) These findings suggest that gamma-interferon may be an important mediator of cachexia in this rat tumor model.
(18) The serum factor inducing hemorrhagic necrosis of transplantable tumors [tumor necrosis factor (TNF)], and the macrophage hormone associated with cachexia in cancer and certain infectious diseases [cachectin] are known to be the same protein.
(19) However, the stimulatory influence of the tumor-bearing state may be overridden by the inhibitory effects of cachexia.
(20) To evaluate the possible role of altered glucose metabolism in malignant cachexia, metabolic parameters including total glucose turnover, glucose oxidation, and Cori cycle activity were measured in fourteen patients with metastatic carcinoma.
Chronic
Definition:
(a.) Relating to time; according to time.
(a.) Continuing for a long time; lingering; habitual.
Example Sentences:
(1) Biochemical, immunocytochemical and histochemical methods were used to study the effect of chronic acetazolamide treatment on carbonic anhydrase (CA) isoenzymes in the rat kidney.
(2) We conclude that chronic emphysema produced in dogs by aerosol administration of papain results in elevated pulmonary artery pressure, which is characterized pathologically by medial hypertrophy of small pulmonary arteries.
(3) Theophylline kinetics, as an in vivo probe for the potentially toxic cytochrome P-450I pathway of drug metabolism, were studied in 11 healthy volunteers and 11 patients with calcific chronic pancreatitis at Madras, South India.
(4) Experience of pain is modified by intern and extern influences, and it can appear very multiformly in the chronicity.
(5) We determined whether serological investigations can assist to distinguish between chronic idiopathic autoimmune thrombocytopenia (cAITP) and immune-mediated thrombocytopenia in patients at risk to develop systemic lupus erythematosus (SLE); 82 patients were seen in this institution for the evaluation of immune thrombocytopenia.
(6) Patients were chronically ill homosexual men with multiple systemic opportunistic infections.
(7) The present study examined whether the lack of chronic hemodynamic effects of ANP in control rats was due to changes in vascular reactivity to the peptide.
(8) Until the 1960's there was great confusion, both within and between countries, on the meaning of diagnostic terms such as emphysema, asthma, and chronic brochitis.
(9) A chronic cannulation procedure is described which allows for sampling vomeronasal organ (VNO) contents repeatedly in freely moving conscious subjects.
(10) During the chronic phase, pain was assessed using visual analogue scales at 8 AM and 4 PM daily.
(11) These data indicate that CSF levels are not inversely related to the blood neutrophil count in chronic idiopathic neutropenia and suggest that CSF is not a hormone regulating the blood neutrophil count in a manner analogous to the erythropoietin regulation of circulating erythrocyte levels.
(12) Erythrocyte membrane choline transport is abnormally high in chronic renal failure.
(13) 1 The effects of chronic ethanol intake on the elimination kinetics of antipyrine were determined in nineteen male alcoholic subjects with comparison made to fourteen male volunteers.
(14) The leukemic T-cells in two patients with chronic lymphocytic leukemia (CLL) had specific features of large granular lymphocytes (LGL), and those in two patients with acute lymphocytic leukemia (ALL) had L2 morphologic characteristics.
(15) The authors conclude that H. pylori alone causes little or no effect on an intact gastric mucosa in the rat, that either intact organisms or bacteria-free filtrates cause similar prolongation and delayed healing of pre-existing ulcers with active chronic inflammation, and that the presence of predisposing factors leading to disruption of gastric mucosal integrity may be required for the H. pylori enhancement of inflammation and tissue damage in the stomach.
(16) Alcohol abuse remains the predominant cause of chronic liver disease in the Western world.
(17) These results show that lipo-PGI2 at a very low dose would be beneficial as a treatment for relieving the clinical symptoms of chronic cerebral infarction and that lipid microspheres are a useful drug carrier for PGI2 analogue therapy.
(18) Anxious mood and other symptoms of anxiety were commonly seen in patients with chronic low back pain.
(19) Asthma is probably the commonest chronic disease in the United Kingdom, and its attendant morbidity extends outside the possible scope of the hospital sector.
(20) We recommend analysing the urine for porphyrins in HIV-positive patients who have chronic photosensitivity of the skin.