(n.) A turning or sliding piece which, by the shape of its periphery or face, or a groove in its surface, imparts variable or intermittent motion to, or receives such motion from, a rod, lever, or block brought into sliding or rolling contact with it.
(n.) A curved wedge, movable about an axis, used for forcing or clamping two pieces together.
(n.) A projecting part of a wheel or other moving piece so shaped as to give alternate or variable motion to another piece against which it acts.
(n.) A ridge or mound of earth.
(a.) Crooked.
Example Sentences:
(1) The combined results suggest that any possible heterogeneity in the L-CAM genes is not reflected in the size of either the mRNA or protein.
(2) The chick chorioallantoic membrane (CAM) model was used to study vascular effects of photodynamic therapy (PDT) and hyperthermia (HPT) and the synergism of these modalities.
(3) These studies indicate that at each site of induction during feather morphogenesis, a general pattern is repeated in which an epithelial structure linked by L-CAM is confronted with periodically propagating condensations of cells linked by N-CAM.
(4) By 3 d in the chick embryo, the first neurons detected by antibodies to Ng-CAM are located in the ventral neural tube; these precursors of motor neurons emit well-stained fibers to the periphery.
(5) CD-349 inhibited the [3H]CD-349 binding to CaM, at a concentration producing a 50% inhibition (IC50) of 2.4 microM, whereas the CaM antagonist, trifluoperazine hydrochloride (TFP), stimulated the [3H]CD-349 binding to CaM.
(6) Comparison of the native and derivatized wheat germ CaMs with native bovine testis CaM indicates that the concentrations of these proteins required for half-maximal stimulation of either erythrocyte membrane Ca2+-ATPase activity or cardiac sarcoplasmic reticulum phosphorylation are very similar.
(7) CAM, especially CD11c, were also detected in cytoplasmic granules by immunostaining in IL2-activated NK cells.
(8) compounds tested, chlordecone is a specific inhibitor of CaM-activated PDE.
(9) In situ hybridization in normal visual cortex revealed a complex sublaminar organization of GAD-expressing cells within layers IVC and VI and a distribution of CaM II kinase alpha-expressing cells that was greatest in layers II, III, IVB, and VI.
(10) We are describing two post-translational modifications; glycosylation and glypiation; which affect the neural cell adhesive molecule (N-CAM).
(11) These results show that mitogenic activation of human fibroblasts leads to the binding of Ca2+ to CaM and the subsequent activation of CaM-dependent processes.
(12) Conversion of S180 cells to a communication-competent phenotype by transfection with a cDNA encoding the cell-cell adhesion molecule L-CAM induced phosphorylation of connexin43 to the P2 form; conversely, blocking junctional communication in ordinarily communication-competent cells inhibited connexin43-P2 formation.
(13) The responsiveness of test tissue to low versus high androgen levels was evaluated in this CAM assay using both cellular morphology and mitotic index as response criteria.
(14) Immunoblot together with immunoprecipitation experiments with cell lines or tissue extracts showed that N-CAM are the major glycoproteins bearing such polysialosyl units.
(15) The fluorescent dihydropyridine calcium antagonist drug felodipine binds to calmodulin (CaM) in a Ca2+-dependent manner.
(16) However, whereas a critical value of N-CAM expression is required for increased neurite outgrowth, with small increases above this value having substantial effects, N-cadherin promotes neurite outgrowth in a highly linear manner.
(17) These results provide structural and functional evidence that CaM and CDP-I act synergistically in the regulated proteolysis of fodrin.
(18) In this study, we examined the modulation of cell surface expression of MHC antigens and the CAM intercellular adhesion molecule 1 (ICAM-1), lymphocyte function antigen 3 (LFA-3), and CD44 on human dermal microvascular endothelial cells (HDMEC) both grown in monolayers and differentiated into capillary-like structures on the basement membrane-like substrate matrigel.
(19) The second type of protein bound 125I-CaM only when the free Ca2+ concentration was below 1-2 microM and included polypeptides of 95 kDa (E95) and 105 kDa (E105).
(20) Day and night forms of phosphoenolpyruvate carboxylase (EC 4.1.1.31) (PEPC) were extracted from leaves of the CAM plants Kalanchoe daigremontiana, K. tubiflora and K. blossfeldiana previously fed with [32P] labelled phosphate solution.
Crank
Definition:
(n.) A bent portion of an axle, or shaft, or an arm keyed at right angles to the end of a shaft, by which motion is imparted to or received from it; also used to change circular into reciprocating motion, or reciprocating into circular motion. See Bell crank.
(n.) Any bend, turn, or winding, as of a passage.
(n.) A twist or turn in speech; a conceit consisting in a change of the form or meaning of a word.
(n.) A twist or turn of the mind; caprice; whim; crotchet; also, a fit of temper or passion.
(n.) A person full of crotchets; one given to fantastic or impracticable projects; one whose judgment is perverted in respect to a particular matter.
(n.) A sick person; an invalid.
(n.) Sick; infirm.
(n.) Liable to careen or be overset, as a ship when she is too narrow, or has not sufficient ballast, or is loaded too high, to carry full sail.
(n.) Full of spirit; brisk; lively; sprightly; overconfident; opinionated.
(n.) To run with a winding course; to double; to crook; to wind and turn.
Example Sentences:
(1) A crank arm length of 170 mm and pedalling rate of 100 rpm correspond closely to the cost function minimum.
(2) Known as crank, crystal, ice, crystal meth, and speed, MAP can be produced easily from ephedrine, and it is widely available.
(3) Eighty degrees further forward, along the minor axis, was the crank arm orientation for the second ellipse, Eng90.
(4) Vote for me, and I will complete the job of rebalancing it... January 28, 2014 12.03pm GMT Britain's businesses need to stop sitting on their cash piles and crank up their investment, argues IPPR’s chief economist Tony Dolphin: “The news that manufacturing is growing is welcome.
(5) A defeated Trump could be expected to be even busier, cranking up what many expect will be a far-right Trump TV network, which he’s already been road testing on Facebook.
(6) It’s a sweet, tender, funny reintroduction to a classic character, and after a few recent PR missteps by Archie Comics – which cranked up Kickstarter campaigns to quickly relaunch other modernised versions of some of its classic titles, before abandoning the idea after complaints from fans and industry professionals – looks like a solid launchpad for its 75th-anniversary celebrations.
(7) The method consists of simultaneously measuring both the normal and tangential pedal forces, the EMGs of eight leg muscles, and the crank arm and pedal angles.
(8) Seven subjects were successively submitted to LBNP exposure, arm cranking physical exercise, and to a combination of both procedures (LBNP + arm cranking) in order to check whether this combination enhances RAAS activity.
(9) A progressive continuous arm cranking test, modified for each group, was employed to elicit maximal responses with pulmonary and metabolic determinations made with open circuit spirometry and selected cardiovascular measurements made by impedance cardiography.
(10) Orgasms were the stuff of the academy and of politics in the 1970s, but now, to go anywhere near that stuff would be a fast and effective way to sound like a crank.
(11) Who else would have decided to leave the relative cosiness of Ditchling Village for Hopkins Crank, an unreconstructed Georgian squatter's cottage and outbuildings on Ditchling Common?
(12) A ceiling fan cranked to full capacity was useless against the oppressive summer heat.
(13) In recent weeks Trump has been cranking up his gender attacks on Clinton, accusing her of playing the woman card and criticising her for being an “enabler” of her husband’s infidelities.
(14) And that allows the viewer to read into them his or her own view of the world, and then cranks up the emotional volume as high as it will go.
(15) This system consists of a flexible rod, sheath, crank, and cam to transmit the muscle power to a pusher plate pump and actuate it.
(16) Analysis of variance (ANOVA) indicated that both peak heart rate (HR) and rate pressure product (RPP) increased significantly with increases in cranking rate across the three tests (p less than .05).
(17) Then came Twitter, which really cranked things up in terms of the terror around your own public persona.
(18) The royal soap opera soon cranked up into a Hollywood blockbuster: the wedding at St Paul’s, the babies, infidelities on both sides, divorce, Diana’s shocking death in Paris, national mourning, Elton John at the funeral.
(19) The first of the extra 12,000 Syrian refugees should arrive in Australia before Christmas as officials crank up a $700m process to select, check and resettle them.
(20) Anyway, grab your party hat and some streamers, crank your German rock way up high and let’s get this party started.