(n.) A turning or sliding piece which, by the shape of its periphery or face, or a groove in its surface, imparts variable or intermittent motion to, or receives such motion from, a rod, lever, or block brought into sliding or rolling contact with it.
(n.) A curved wedge, movable about an axis, used for forcing or clamping two pieces together.
(n.) A projecting part of a wheel or other moving piece so shaped as to give alternate or variable motion to another piece against which it acts.
(n.) A ridge or mound of earth.
(a.) Crooked.
Example Sentences:
(1) The combined results suggest that any possible heterogeneity in the L-CAM genes is not reflected in the size of either the mRNA or protein.
(2) The chick chorioallantoic membrane (CAM) model was used to study vascular effects of photodynamic therapy (PDT) and hyperthermia (HPT) and the synergism of these modalities.
(3) These studies indicate that at each site of induction during feather morphogenesis, a general pattern is repeated in which an epithelial structure linked by L-CAM is confronted with periodically propagating condensations of cells linked by N-CAM.
(4) By 3 d in the chick embryo, the first neurons detected by antibodies to Ng-CAM are located in the ventral neural tube; these precursors of motor neurons emit well-stained fibers to the periphery.
(5) CD-349 inhibited the [3H]CD-349 binding to CaM, at a concentration producing a 50% inhibition (IC50) of 2.4 microM, whereas the CaM antagonist, trifluoperazine hydrochloride (TFP), stimulated the [3H]CD-349 binding to CaM.
(6) Comparison of the native and derivatized wheat germ CaMs with native bovine testis CaM indicates that the concentrations of these proteins required for half-maximal stimulation of either erythrocyte membrane Ca2+-ATPase activity or cardiac sarcoplasmic reticulum phosphorylation are very similar.
(7) CAM, especially CD11c, were also detected in cytoplasmic granules by immunostaining in IL2-activated NK cells.
(8) compounds tested, chlordecone is a specific inhibitor of CaM-activated PDE.
(9) In situ hybridization in normal visual cortex revealed a complex sublaminar organization of GAD-expressing cells within layers IVC and VI and a distribution of CaM II kinase alpha-expressing cells that was greatest in layers II, III, IVB, and VI.
(10) We are describing two post-translational modifications; glycosylation and glypiation; which affect the neural cell adhesive molecule (N-CAM).
(11) These results show that mitogenic activation of human fibroblasts leads to the binding of Ca2+ to CaM and the subsequent activation of CaM-dependent processes.
(12) Conversion of S180 cells to a communication-competent phenotype by transfection with a cDNA encoding the cell-cell adhesion molecule L-CAM induced phosphorylation of connexin43 to the P2 form; conversely, blocking junctional communication in ordinarily communication-competent cells inhibited connexin43-P2 formation.
(13) The responsiveness of test tissue to low versus high androgen levels was evaluated in this CAM assay using both cellular morphology and mitotic index as response criteria.
(14) Immunoblot together with immunoprecipitation experiments with cell lines or tissue extracts showed that N-CAM are the major glycoproteins bearing such polysialosyl units.
(15) The fluorescent dihydropyridine calcium antagonist drug felodipine binds to calmodulin (CaM) in a Ca2+-dependent manner.
(16) However, whereas a critical value of N-CAM expression is required for increased neurite outgrowth, with small increases above this value having substantial effects, N-cadherin promotes neurite outgrowth in a highly linear manner.
(17) These results provide structural and functional evidence that CaM and CDP-I act synergistically in the regulated proteolysis of fodrin.
(18) In this study, we examined the modulation of cell surface expression of MHC antigens and the CAM intercellular adhesion molecule 1 (ICAM-1), lymphocyte function antigen 3 (LFA-3), and CD44 on human dermal microvascular endothelial cells (HDMEC) both grown in monolayers and differentiated into capillary-like structures on the basement membrane-like substrate matrigel.
(19) The second type of protein bound 125I-CaM only when the free Ca2+ concentration was below 1-2 microM and included polypeptides of 95 kDa (E95) and 105 kDa (E105).
(20) Day and night forms of phosphoenolpyruvate carboxylase (EC 4.1.1.31) (PEPC) were extracted from leaves of the CAM plants Kalanchoe daigremontiana, K. tubiflora and K. blossfeldiana previously fed with [32P] labelled phosphate solution.
Lever
Definition:
(a.) More agreeable; more pleasing.
(adv.) Rather.
(n.) A rigid piece which is capable of turning about one point, or axis (the fulcrum), and in which are two or more other points where forces are applied; -- used for transmitting and modifying force and motion. Specif., a bar of metal, wood, or other rigid substance, used to exert a pressure, or sustain a weight, at one point of its length, by receiving a force or power at a second, and turning at a third on a fixed point called a fulcrum. It is usually named as the first of the six mechanical powers, and is of three kinds, according as either the fulcrum F, the weight W, or the power P, respectively, is situated between the other two, as in the figures.
(n.) A bar, as a capstan bar, applied to a rotatory piece to turn it.
(n.) An arm on a rock shaft, to give motion to the shaft or to obtain motion from it.
Example Sentences:
(1) In this experiment animals were trained to lever press in two distinctive contexts.
(2) Orientation and lever responding were not functionally related.
(3) In older stages, the cervical joints rotate according to geometric and lever arm principles.
(4) In EastEnders , the mystery surrounding the identity of Kat's secret squeeze continues amid the grinding of narrative levers and the death rattle of overflogged script-horses.
(5) Cats were trained to press a lever for 0.5--1.0 ml of milk reward both in the presence and absence of ambient light.
(6) Setting out how Britain would have a lever over the rest of the EU to demand repatriation of UK competences, Cameron said: "What's happening in Europe right now is massive change being driven by the existence of the euro.
(7) When lever pressing was established, the 2-kHz signal was presented through a speaker adjacent to the response lever according to a different set of variable intertrial intervals.
(8) Officials said the changes to the planning rules will mean it is possible to lever in billions of private sector development in low-cost housing.
(9) Rats were allowed to bar press on either of two levers (left and right).
(10) Knee flexion is synchronized with ankle dorsiflexion by a synchronizer rod and lever.
(11) In order to study the interactions between serotonergic mechanism and electrical stimulation of the mesencephalic central gray substance, rats were trained to lever-press for terminating aversive electric stimuli applied at the Periaqueductal gray and adjoining tectum of the mesencephalon.
(12) Rats were trained to press a lever to obtain a brief burst of pulses to the lateral hypothalamus.
(13) But its original meaning is the practice of using the levers of the state and of government to get difficult things done that otherwise wouldn't happen.
(14) Intact rats and rats bearing lesions of the suprachiasmatic nuclei (SCNX rats) were trained to obtain food by pressing either of two levers located on opposite sides of a cylindrical cage.
(15) We found that attenuation of lever-pressing and water intake by raclopride were not more separated in dose than after, for example, haloperidol.
(16) Young rats weaned at 16 days were taught to press a lever by shaping at 18 days and trained for 11 days (from 20 to 30 days of age) on a fixed-interval 60-sec schedule, at a rate of 5 half-hour sessions per day.
(17) In contrast, the selective norepinephrine uptake inhibitors, desipramine and talsupram, and the selective serotonin uptake inhibitor, citalopram, occasioned averages of only 13 to 19% drug-lever responding.
(18) When reinforcement was not available, each lever response produced a 0.5-sec green light on the key.
(19) Rats implanted with placebo pellets and given access to morphine reestablished lever pressing, while those given access to isotonic saline extinguished their lever pressing.
(20) Levels of acetylcholine were significantly elevated in the telencephalon and diencephalon + mesencephalon of rats killed by near-freezing during conditioned suppression of food-reinforced lever pressing, whereas levels of serotonin, dopamine, and norepinephrine were not altered.