(1) The subunits also differ in regulation as determined by their interactions with a purified type I regulatory subunit, which has an IC50 for CAPL-A1 that is 3.5 times higher than the IC50 for CAPL-A2.
(2) CAPL-A1 and CAPL-A2, two catalytic subunits of Aplysia cAMP-dependent protein kinase, are encoded by mRNAs generated by alternative splicing of transcripts of a gene that contains two mutually exclusive exon cassettes.
(3) CAPL transcripts are present in several classes of identified neurons containing transmitter-sensitive adenylate cyclase, including sensory cells, bag cells, and the left pleural giant cell.
(4) Cacy is shown to be within 8 kb of Capl in the mouse genome.
(5) CAPL-A1 and CAPL-A2 have now been expressed in insect cells and purified to homogeneity.
(6) CAPL-A1 and CAPL-A2 have different substrate specificities.
(7) cDNA probes for the related genes calcyclin (CACY) and a mouse placental protein (18A2, suggested name Capl) enabled us to confirm and refine the in situ hybridization result assigning CACY to chromosome 1q21-25 and to demonstrate that both genes cosegregate with CAGA and CAGB.
(8) Peripheral blood leukocytes from rainbow trout were found to be caple of participating in a mixed leukocyte reaction.
(9) Interestingly, the expression pattern of S100 alpha, CACY, and CAPL in human tissues differs significantly from that in rodent tissues.
(10) They derive from alternatively spliced transcripts of a single gene (CAPL) containing two mutually exclusive exon cassettes.
(11) Whereas CACY and CAPL mRNAs are expressed ubiquitously, S100 alpha mRNA is restricted to heart, skeletal muscle, and brain.
(12) Capl was mapped to a region of chromosome 3 in the mouse using the BXD recombinant inbred strain mice where the p11 protein (calpactin light chain Cal1l), another S100 family member, has been localized.
(13) Transcripts encoding CAPL-B, an apparent member of the cyclic-nucleotide-regulated kinase subfamily in Aplysia californica, are found exclusively in the ovotestis and are concentrated in meiotic and postmeiotic spermatogenic cells.
(14) The CAPL-B polypeptide is present in mature spermatozoa, suggesting that the kinase plays a part in regulating events associated with fertilization.
(15) By PCR technology we identified three members of the S100 protein family (S100 alpha, CACY, and CAPL) in the human heart.
(16) For example, kcat and Km values for the peptide LRRASLG (kemptide) are 42 s-1 and 36 microM and 28 s-1 and 17 microM for CAPL-A1 and CAPL-A2, respectively.
Horse
Definition:
(n.) A hoofed quadruped of the genus Equus; especially, the domestic horse (E. caballus), which was domesticated in Egypt and Asia at a very early period. It has six broad molars, on each side of each jaw, with six incisors, and two canine teeth, both above and below. The mares usually have the canine teeth rudimentary or wanting. The horse differs from the true asses, in having a long, flowing mane, and the tail bushy to the base. Unlike the asses it has callosities, or chestnuts, on all its legs. The horse excels in strength, speed, docility, courage, and nobleness of character, and is used for drawing, carrying, bearing a rider, and like purposes.
(n.) The male of the genus horse, in distinction from the female or male; usually, a castrated male.
(n.) Mounted soldiery; cavalry; -- used without the plural termination; as, a regiment of horse; -- distinguished from foot.
(n.) A frame with legs, used to support something; as, a clotheshorse, a sawhorse, etc.
(n.) A frame of timber, shaped like a horse, on which soldiers were made to ride for punishment.
(n.) Anything, actual or figurative, on which one rides as on a horse; a hobby.
(n.) A mass of earthy matter, or rock of the same character as the wall rock, occurring in the course of a vein, as of coal or ore; hence, to take horse -- said of a vein -- is to divide into branches for a distance.
(n.) See Footrope, a.
(a.) A breastband for a leadsman.
(a.) An iron bar for a sheet traveler to slide upon.
(a.) A jackstay.
(v. t.) To provide with a horse, or with horses; to mount on, or as on, a horse.
(v. t.) To sit astride of; to bestride.
(v. t.) To cover, as a mare; -- said of the male.
(v. t.) To take or carry on the back; as, the keeper, horsing a deer.
(v. t.) To place on the back of another, or on a wooden horse, etc., to be flogged; to subject to such punishment.
(v. i.) To get on horseback.
Example Sentences:
(1) Such was the mystique surrounding Rumsfeld's standing that an aide sought to clarify that he didn't stand all the time, like a horse.
(2) Hyperimmunization with the tick encephalitis and Western horse encephalomyelitis viruses reproduced in the brain of albino mice, intensified the protein synthesis in the splenic tissue during the productive phase of the immunogenesis (the 7th day).
(3) Electron self-exchange has been measured by an NMR technique for horse-heart myoglobin.
(4) By adjustment to the swaying movements of the horse, the child feels how to retain straightening alignment, symmetry and balance.
(5) Biosyntheses of TXA2 and PGI2 were carried out using arachidonic acid as a substrate and horse platelet and aorta microsomes as sources of TXA2 and PGI2 synthetases respectively.
(6) The Sports Network broadcasts live NHL, Nascar, golf and horse racing – having also recently purchased the rights for Formula One – and will show 154 of the 196 games that NBC will cover.
(7) Just before Christmas the independent Kerslake report severely criticised Birmingham city council for its dysfunctional politics and, in particular, its handling of the so-called Trojan Horse affair, in which school governors were said to have set out to bring about an Islamic agenda into the curriculum contents and the day-to-day running of some schools.
(8) The subjects were divided into 4 ages groups, each comprising 8 horses (4 of each sex).
(9) The assay was developed using serum antibodies collected from horses convalescing from strangles.
(10) One middle carpal joint of each horse was injected 3 times with 100 mg of 6-alpha-methylprednisolone acetate, at 14-day intervals.
(11) Horses in heavy training may require more energy than they can consume on a conventional diet.
(12) These melanocytic tumors in young horses are distinct from melanomas in aged horses in their location, epithelial involvement, and age of horses affected.
(13) This finding supports the view that their sphincteroid action would be less efficient and that an additional closing mechanism of vascular origin may be required at the ileocaecal papilla of the horse.
(14) Report on the results of serological studies on the species Leptospira interrogans in cattle (19,607), swine (6,348), dogs (182) and horses (88) from the Netherlands during the period from 1969 to 1974.
(15) When rabbit and horse sera were used instead of human serum for cultivation, in both groups the share of positive cultures increased and more large forms of B. hominis cells were observed.
(16) Bacteriologic culturing of fecal samples from 28 clinically normal horses yielded only 2 salmonella isolations, S manhattan in each case.
(17) The wide variation in potency explains the variation found in absolute bioavailability, and the increase in release rate when the pellets are crushed explains the differences seen in peak plasma times, since the pellets will be chewed to varying degrees by the horse.
(18) Five horses raced successfully and lowered the lifetime race records, 1 horse was sound and trained successfully, but died of colic, and 1 horse was not lame in early training.
(19) It’s exhilarating – until you see someone throw a firework at a police horse.
(20) Western immunoblot reactivity showed that the antisera collected from these infected horses at 4 to 5 weeks PI recognized some or all of the six major E. risticii component antigens (70, 55, 51, 44, 33, and 28 kilodaltons), all of which were apparent surface components.