(1) The subunits also differ in regulation as determined by their interactions with a purified type I regulatory subunit, which has an IC50 for CAPL-A1 that is 3.5 times higher than the IC50 for CAPL-A2.
(2) CAPL-A1 and CAPL-A2, two catalytic subunits of Aplysia cAMP-dependent protein kinase, are encoded by mRNAs generated by alternative splicing of transcripts of a gene that contains two mutually exclusive exon cassettes.
(3) CAPL transcripts are present in several classes of identified neurons containing transmitter-sensitive adenylate cyclase, including sensory cells, bag cells, and the left pleural giant cell.
(4) Cacy is shown to be within 8 kb of Capl in the mouse genome.
(5) CAPL-A1 and CAPL-A2 have now been expressed in insect cells and purified to homogeneity.
(6) CAPL-A1 and CAPL-A2 have different substrate specificities.
(7) cDNA probes for the related genes calcyclin (CACY) and a mouse placental protein (18A2, suggested name Capl) enabled us to confirm and refine the in situ hybridization result assigning CACY to chromosome 1q21-25 and to demonstrate that both genes cosegregate with CAGA and CAGB.
(8) Peripheral blood leukocytes from rainbow trout were found to be caple of participating in a mixed leukocyte reaction.
(9) Interestingly, the expression pattern of S100 alpha, CACY, and CAPL in human tissues differs significantly from that in rodent tissues.
(10) They derive from alternatively spliced transcripts of a single gene (CAPL) containing two mutually exclusive exon cassettes.
(11) Whereas CACY and CAPL mRNAs are expressed ubiquitously, S100 alpha mRNA is restricted to heart, skeletal muscle, and brain.
(12) Capl was mapped to a region of chromosome 3 in the mouse using the BXD recombinant inbred strain mice where the p11 protein (calpactin light chain Cal1l), another S100 family member, has been localized.
(13) Transcripts encoding CAPL-B, an apparent member of the cyclic-nucleotide-regulated kinase subfamily in Aplysia californica, are found exclusively in the ovotestis and are concentrated in meiotic and postmeiotic spermatogenic cells.
(14) The CAPL-B polypeptide is present in mature spermatozoa, suggesting that the kinase plays a part in regulating events associated with fertilization.
(15) By PCR technology we identified three members of the S100 protein family (S100 alpha, CACY, and CAPL) in the human heart.
(16) For example, kcat and Km values for the peptide LRRASLG (kemptide) are 42 s-1 and 36 microM and 28 s-1 and 17 microM for CAPL-A1 and CAPL-A2, respectively.
Maple
Definition:
(n.) A tree of the genus Acer, including about fifty species. A. saccharinum is the rock maple, or sugar maple, from the sap of which sugar is made, in the United States, in great quantities, by evaporation; the red or swamp maple is A. rubrum; the silver maple, A. dasycarpum, having fruit wooly when young; the striped maple, A. Pennsylvanium, called also moosewood. The common maple of Europe is A. campestre, the sycamore maple is A. Pseudo-platanus, and the Norway maple is A. platanoides.
Example Sentences:
(1) Branched-chain keto acid decarboxylase activity in skin fibroblasts from control subjects and from patients with classical and variant forms of maple syrup urine disease (MSUD) was measured with leucine and alpha-ketoisocaproic acid.
(2) During dietary treatment of a case of maple syrup urine disease, it was found that abnormal EEGs were observed when serum levels of leucine were abnormally high while those of valine and isoleucine were normal, and also when serum levels of valine and isoleucine were abnormally high while serum leucine levels were normal.
(3) Intermittend maple-syrup-urine disease was excluded by oral loading tests with the branched-chain amino acids and with an isocaloric, high-protein diet.
(4) Screening for tyrosinaemia, alpha 1-antitrypsin deficiency, maple syrup urine disease and histidinaemia has been discontinued.
(5) As he was detained, the gunman, wearing a balaclava and a bathrobe, allegedly repeated twice in French with an English accent: "The Anglophones are waking up," an apparent reference to the "maple spring" of student protests against the government that contributed to the snap election being called.
(6) The progress of nine maple syrup urine disease patients (eight classical, one possible variant) was reviewed to look for similarities in developmental patterns.
(7) He now sells over 2,000 litres of milk each week on doorsteps, in restaurants and it’s sold at the local shops for £1.20 a litre under the label Maple Field Milk .
(8) • carteblanchefoodcart.com Miss Kate's Southern Kitchen Miss Kate's Southern Kitchen Photograph: Marina O'Loughlin for the Guardian This folksy cart dishes out Southern comfort food: freshly made mac 'n' cheese, pumpkin-spiced waffles with maple butter, meatloaf and succotash .
(9) The Nature's Calendar project invites people across the country to log their first sightings of autumnal tints on ash, beech, field maple, horse chestnut, oak, rowan, silver birch and sycamore trees.
(10) Maple syrup urine disease (MSUD) results from an inborn metabolic error caused by a deficiency of the branched-chain alpha-ketoacid dehydrogenase complex (BCKDC).
(11) Branched chain alpha-ketoacid dehydrogenase (BCKDH) deficiency results in maple syrup urine disease (MSUD).
(12) Cultured cells of normal individuals and nine patients with different clinical pictures of maple syrup urine disease (MSUD) are studied with both alpha-ketoisocaproic acid (2-oxo-4-methylpentanoic acid (KIC)) and alpha-ketoisovaleric acid (2-oxo-3-methylbutanoic acid (KIVA)) as substrates.
(13) The activity of the branched-chain alpha-keto acid dehydrogenase complex is deficient in patients with the inherited maple syrup urine disease (MSUD).
(14) A case of hypersensitivity pneumonitis is presented which was associated with exposure to Cryptostroma corticale from non-maple bark chips used to grow orchids.
(15) The rats produced IgE antibodies to each of the allergens used (maple, willow, poplar, ash, oak, sycamore, hickory, walnut, birch, and elm), yet the allergens had extremely limited cross-reactivity.
(16) CAVH allowed good compensation of azotemia in critically ill children with acute renal failure, rapid correction of severe hypervolemia, interstitial pulmonary edema, electrolyte disorders, and metabolic crisis in maple syrup urine disease.
(17) Branched chain alpha-ketoacid dehydrogenase (BCKAD) deficiency, or maple syrup urine disease (MSUD), can be categorized as classical, intermediate, intermittent or thiamine responsive, based on generally concordant in vitro BCKAD activity and severity of phenotype.
(18) On what was to become a hot and nearly cloudless day Canadians trudged towards the site, most wearing the national colours, many carrying maple leaf flags in their hair or on their baseball caps or T-shirts.
(19) The molecular basis of one maple syrup urine disease family has been determined for the first time.
(20) Deciduous trees growing in a natural forest on the hillsides downslope from the site were sampled for the presence of tritiated water in sap of maple trees and in leaf water extracted from oak and hickory trees.