(v. t.) To deprive of the testicles; to emasculate; to geld; to alter.
(v. t.) To cut or take out; esp. to remove anything erroneous, or objectionable from, as the obscene parts of a writing; to expurgate.
Example Sentences:
(1) Intact rams exhibited GH secretory episodes of greater (P less than 0.01) amplitude than did castrated lambs.
(2) Positive feedback effects on serum gonadotrophins in castrates were observed following injection of certain doses of some steroids.
(3) In contrast, castration during pseudopregnancy did not abolish the secondary peaks.
(4) No specific labeling could be detected in the adrenocorticotrophs of adrenalectomized rats or gonadotrophs (castration cells) of castrated rats.
(5) In a final experiment, prostatic atrophy in castrate rats was not enhanced by either adrenalectomy or flutamide treatment.
(6) Castrated rams did not show this increase, with or without supplementary testosterone.
(7) Naloxone also prevented testosterone's negative feedback inhibition of serum LH in the castrated male rat.
(8) Moreover, the levels of these parameters were comparable in tumours whether implanted in non-castrated or gonadectomized animals.
(9) Castration of male rats results in a decrease in submandibular gland RSKG-7 mRNA, which can be restored to the normal level by treatment with thyroxine or testosterone.
(10) In vivo administration of anti-EGF antibody or anti-TGF-alpha antibody significantly reduced estrogen-induced labelling index in castrated mouse uterus.
(11) In castrates, the prostatic stroma became thickened, with a large increase in fibrous material between and surrounding each acinus, although smooth muscle cells retained their normal cytology.
(12) Median survival was significantly prolonged in primed animals 191 vs 40 days for untreated animals and 150 days for the nonprimed castration + chemotherapy animals (P less than 0.02).
(13) Adreno-cortical compensation of the concentration of the hormone did not occur in the post-castration period.
(14) Rat dorsal prostate epithelium was studied in intact adult animals, in animals castrated for three days and in rats after inhibition of prolactin secretion.
(15) The ability of melatonin to influence LH pulse frequency in entire and castrated rams indicated that an effect of melatonin on the hypothalamic pulse generator is independent of testicular steroids.
(16) The treatment with supraphysiological doses of the gonadotropin releasing hormone analogue Buserelin results in the suppression of serum testosterone to castration range with a probability of 95% after 28 days.
(17) To determine the effect of photoperiod on substance P, peptide containing neurons were counted in (1) enucleates (n = 6), (2) enucleated castrates treated with testosterone (n = 6), (3) castrates treated with testosterone (n = 4), and (4) intact controls (n = 6).
(18) In addition, there was a marginally significant (P less than 0.1) relationship between prolactin secretion in the castrate ram and the stage of testicular activity in the entire rams with elevated levels associated with regressed activity.
(19) In terms of total cellular receptor content, initial levels were higher in castrate animals, but rapidly fell to intact levels within an hour following estradiol injection.
(20) The effect of naloxone administration on the LH-RH secretion in hypophyseal portal blood and LH secretion in peripheral blood was studied in four short term castrated rams (between 2 to 4 days after castration).
Spay
Definition:
(v. t.) To remove or extirpate the ovaries of, as a sow or a bitch; to castrate (a female animal).
(v. t.) The male of the red deer in his third year; a spade.
Example Sentences:
(1) The cAMP-dependent protein kinase (ATP:protein phosphotransferase, EC 2.7.1.37), has been studied in the vaginal epithelium, vaginal stroma, endometrium, and whole uterus of spayed mice treated with oestradiol-17 beta, and in the vaginal epithelium and uterus of spayed mice.
(2) Sequential P treatment reduced the degree of nuclear staining in the oviduct and endometrium below that found in spayed animals; however, such treatment only lowered the amount of cytosolic, not nuclear, ER significantly below spayed levels in those same tissues.
(3) Therefore, the effect of E on GH in spayed monkeys cannot be accounted for by a direct action on somatotrophs.
(4) Its concentration was maximal at proestrus and after administering 2-20 microgram of estradiol to spayed rats.
(5) The mean age of dogs with urinary bladder neoplasia was 9.5 years; 6 were males, 13 were females, and 2 were spayed females.
(6) Staphylococcus aureus and Streptococcus canis were the most frequently isolated bacteria in specimens collected from the vagina (in the area of the urethral orifice) of 20 normal intact bitches and 20 spayed bitches.
(7) However, when calculated on the basis of the DNA content of the myometrium, which was 8 times higher in the spayed than in the pregnant animals, the specific activities were lower in the tissue from spayed animals.
(8) Scedosporium inflatum Malloch et Salkin was found to cause osteomyelitis in a 6-year-old spayed female beagle.
(9) Mating during a period of 40 min at the beginning of hormonally induced estrus in spayed female rats resulted in a rapid decrease in receptivity as measured hourly by the lordosis response.
(10) Cerebral phaeohyphomycosis was diagnosed in a 9-year-old spayed dog that had a series of epileptic convulsions a day before death.
(11) Spayed animals were given progesterone for 4 days and then an injection of BCG serum or vaccine in 1 uterine horn.
(12) If the spayed beagle dam can be considered a model in which one may equivalate bone changes occurring in the ovarian hormone-deficient human female, we reach the following conclusions: The presence or absence of quasi-physiological levels of single ovarian hormones do affect the status of trabecular bone.
(13) Resorptive and formative characteristics on the periosteal and corticoendosteal bone envelopes were assessed on the ribs of intact, spayed and medroxyprogesterone acetate (MPA)-supplemented Beagle dams.
(14) A 5-y-old spayed female Corgi dog was dipped with a d-limonene-based compound for flea infestation.
(15) A correspondence between the appearance of vaginal smears and the layers of the epithelium from which the cells had desquamated was established in untreated rats during the estrous cycle, in control ovariectomized rats and in spayed rats injected with either estrogen or progesterone.
(16) Thirteen adult cycling female cynomolgus monkeys were ovariectomized and treated for 28 days with 1) an empty Silastic capsule (Spay), 2) a 2-cm E-filled capsule (E), or 3) a 2-cm E-filled capsule for 14 days plus a 6-cm P-filled capsule implanted for an additional 14 days (E + P).
(17) A 6-year-old, obese, spayed female Doberman pinscher dog was presented for clinical examination with a 1-day history of repeated seizures and a long-term history of periodic bouts of ataxia, circling, and head tilt.
(18) Treatment of carcinomas in spayed (hormone-independent), nonspayed (hormone-dependent) rats, and of tumors which were refractory to treatment with estradiol dipropionate caused regression of the tumors.
(19) The report cites the results of three experiments designed to determine the effect of estrogen treatment on spayed and entire ewes.
(20) When small amounts of this compound were applied to the vulvas of anestrous or spayed females, males placed with these females became sexually aroused and attempted to mount them.