(1) Intact rams exhibited GH secretory episodes of greater (P less than 0.01) amplitude than did castrated lambs.
(2) Positive feedback effects on serum gonadotrophins in castrates were observed following injection of certain doses of some steroids.
(3) In contrast, castration during pseudopregnancy did not abolish the secondary peaks.
(4) No specific labeling could be detected in the adrenocorticotrophs of adrenalectomized rats or gonadotrophs (castration cells) of castrated rats.
(5) In a final experiment, prostatic atrophy in castrate rats was not enhanced by either adrenalectomy or flutamide treatment.
(6) Castrated rams did not show this increase, with or without supplementary testosterone.
(7) Naloxone also prevented testosterone's negative feedback inhibition of serum LH in the castrated male rat.
(8) Moreover, the levels of these parameters were comparable in tumours whether implanted in non-castrated or gonadectomized animals.
(9) Castration of male rats results in a decrease in submandibular gland RSKG-7 mRNA, which can be restored to the normal level by treatment with thyroxine or testosterone.
(10) In vivo administration of anti-EGF antibody or anti-TGF-alpha antibody significantly reduced estrogen-induced labelling index in castrated mouse uterus.
(11) In castrates, the prostatic stroma became thickened, with a large increase in fibrous material between and surrounding each acinus, although smooth muscle cells retained their normal cytology.
(12) Median survival was significantly prolonged in primed animals 191 vs 40 days for untreated animals and 150 days for the nonprimed castration + chemotherapy animals (P less than 0.02).
(13) Adreno-cortical compensation of the concentration of the hormone did not occur in the post-castration period.
(14) Rat dorsal prostate epithelium was studied in intact adult animals, in animals castrated for three days and in rats after inhibition of prolactin secretion.
(15) The ability of melatonin to influence LH pulse frequency in entire and castrated rams indicated that an effect of melatonin on the hypothalamic pulse generator is independent of testicular steroids.
(16) The treatment with supraphysiological doses of the gonadotropin releasing hormone analogue Buserelin results in the suppression of serum testosterone to castration range with a probability of 95% after 28 days.
(17) To determine the effect of photoperiod on substance P, peptide containing neurons were counted in (1) enucleates (n = 6), (2) enucleated castrates treated with testosterone (n = 6), (3) castrates treated with testosterone (n = 4), and (4) intact controls (n = 6).
(18) In addition, there was a marginally significant (P less than 0.1) relationship between prolactin secretion in the castrate ram and the stage of testicular activity in the entire rams with elevated levels associated with regressed activity.
(19) In terms of total cellular receptor content, initial levels were higher in castrate animals, but rapidly fell to intact levels within an hour following estradiol injection.
(20) The effect of naloxone administration on the LH-RH secretion in hypophyseal portal blood and LH secretion in peripheral blood was studied in four short term castrated rams (between 2 to 4 days after castration).
Orchidectomy
Definition:
Example Sentences:
(1) Most importantly, the hypersecretion of FSH observed during the first 2 days after immunoneutralization of circulating inhibin was indistinguishable from that elicited during the initial 2 days after subsequent bilateral orchidectomy and concomitant testosterone (T) replacement.
(2) At 48 h after bilateral orchidectomy, a significant decrease in putrescine content was observed, but spermidine and spermine content were unaffected.
(3) The purpose of the present study was to identify the existence of sexual dimorphism in the dendritic field of accessory olfactory bulb mitral cells in rats and to investigate the effects of male orchidectomy and female androgenization on the day of birth upon this dendritic field.
(4) Orchidectomy as well as single drug intramuscular or oral + intramuscular estrogens exerted a similar suppressive effect on basal levels of A-4 and 17-OHP.
(5) Orchidectomy caused a small, but consistent rise in response.
(6) Orchidectomy in male rats leads to a) an increase in serum LH and FSH within 9 h; b) a decrease in serum testosterone to baseline levels by 30 min; c) an increase in serum progesterone (for 30 to 120 min), in the presence of the adrenals.
(7) At 6 months, SHBG levels had increased to 617% of pretreatment values in the oral EE2 group, to 166% in the 320 mg group, and were unaffected by orchidectomy.
(8) The BMI and cholesterol values obtained 4 to 6 years after chemotherapy were compared with values from a sample of healthy, age-matched Dutch men; the cholesterol level was also compared with that of 31 patients treated with orchidectomy for stage I disease.
(9) Many animal experiments and several clinical phase II and phase III trials have demonstrated that it deserves a place in the endocrine therapy of advanced prostate cancer, particularly for those patients who find orchidectomy unacceptable and who do not have known cardiovascular risks.
(10) By 2 years post-orchidectomy, seven patients (4.9%) in the irradiated group developed duodenal ulceration compared to none in the surveillance group (p = 0.05).
(11) The effect of unilateral or bilateral orchidectomy on tissue plasminogen activator activity (PAA), plasminogen activator inhibition (PAI) and plasmin inhibition (PI) was studied in the rat.
(12) It can be extremely difficult to distinguish histologically between Leydig cell tumours and adrenocortical rest hyperplasia which may lead in some cases to unnecessary orchidectomy in young men.
(13) It is concluded that intranasal buserelin is an effective, simple and safe method to achieve androgen deprivation and is an alternative to orchidectomy in the treatment of advanced prostatic cancer.
(14) Orchidectomy or testicular irradiation with 24 to 30 Gy are recommended for testicular involvement in boys with acute lymphoblastic leukemia.
(15) SHBG serum levels were highly increased by oral estrogens, slightly increased by parenteral estrogens, and unaffected by orchidectomy.
(16) Apart from orchidectomy, surgery was not the first modality of treatment.
(17) The authors made a randomized prospective study of estrogen therapy versus orchidectomy in patients with prostatic cancer (n = 100, Huddinge Hospital, Sweden) to investigate the possibility of predicting cardiovascular events during hormonal treatment.
(18) A very strong gastroprotective effect in basal conditions has been modulated by ovariectomy and demedullation (abolishment), thyroparathyroidectomy (decrease), and no change occurred in case of vagotomy, splenectomy or orchidectomy.
(19) These changes were accentuated after an orchidectomy.
(20) Serum concentrations of testosterone, luteinizing hormone (LH) and follicle-stimulating hormone (FSH) were determined before and after orchidectomy performed at different intervals (2-29 months) after withdrawal of estrogen therapy in patients with prostatic carcinoma.