(1) Injection of a low dose of haloperidol, that has no obvious behavioral effects in normal mice, produces akinesia, catalepsy, and somatosensory neglect in MPTP-treated mice.
(2) The novel anxiolytic drug, buspirone, reverses catalepsy induced by haloperidol.
(3) Indomethacin and studied prostaglandins did not influence inhibitory action of FDP on haloperidol-induced catalepsy.
(4) Both antagonists produced catalepsy as evidenced by dose-dependent increases in step- down latency.
(5) Joint administration of WA-335 and L-DOPA with an inhibitor of peripheral decarboxylase, or WA-335 and amantadine produced a stronger antagonistic effect (spiroperidol catalepsy) than either of these substances separately.
(6) Finally 6 patients undergoing DDP with Timiperone in combination with trihexyphenidyl suffered no symptoms of catalepsy but sometimes had mild vomiting episodes (1-4 times a day).
(7) Finally, Lu 19-005 antagonized the catalepsy induced by perphenazine.
(8) All rats were tested for catalepsy and at the end of the last catalepsy test, striatal DOPAC, HVA and ACh were determined.
(9) Bilateral intrastriatal injections of quinolinic acid (QA) (180 nmoles) induced weight loss and neurologic and behavioral deficits including convulsions, decreased catalepsy response to haloperidol, increased nocturnal locomotor activity, and abnormal feeding behavior in adult male Sprague-Dawley rats.
(10) Studies on the mechanism of post-etorphine catalepsy.
(11) This dose of haloperidol alone caused only a slight, gradually developing catalepsy, while alphaMT alone caused none.
(12) Administration of oxotremorine to mice produced centrally-mediated effects, such as catalepsy and tremor, and peripheral muscarinic actions, such as diarrhoea and lachrymation.
(13) The results, together with a literature survey on the anticholinergic effects on neuroleptic-induced catalepsy and inhibition of avoidance behavior, are related to biochemical findings and clinical effects.
(14) The action of opiates leading to an inhibition of flexor alpha-motoneurones may contribute to akinesia and catalepsy, and opioid-induced muscular rigidity.
(15) In a second experiment, thioridazine, dopamine, norepinephrine, serotonin and their metabolites were assayed in the brain of the rat after acute administration of the enantiomers of thioridazine and the assessment of catalepsy.
(16) When the catalepsy score was almost maximal (60 s, measured by the bar-test), the rats were handled, exposed to cold (3 degrees C) or immobilized.
(17) A series of aryl-piperazine analogues of buspirone and other 5-hydroxytryptaminergic agonists were tested for their ability to reverse haloperidol induced catalepsy.
(18) MK-801 also potentiated the anticataleptic effect of scopolamine and bromocriptine against haloperidol-induced catalepsy.
(19) Striatal dopamine (DA) stores were only minimally depleted at the time of catalepsy potentiation.
(20) Catalepsy, measured by the duration of loss of righting reflex (DLRR) in catatonic animals, was induced by larger doses of both ketamine and morphine and in each case was reduced by a larger dose of naloxone.
Cataleptic
Definition:
(a.) Pertaining to, or resembling, catalepsy; affected with catalepsy; as, a cataleptic fit.
Example Sentences:
(1) Loss of the righting response was not associated with any gross reduction in skeletal muscle tone (inclined screen and wire grip tests) and it was proposed that the animals were not anaesthetized but instead could be placed on their backs because flurazepam had enhanced the cataleptic effect of THC.
(2) The PG F2a- and haloperidol-induced cataleptic behaviors were almost abolished by the thermal coagulation of bilateral striatum where the dopaminergic and cholinergic link is found.
(3) Metaphit pretreatment increased the cataleptic effects induced by cumulative doses of PCP-type drugs (i.e., PCP, ketamine and m-amino PCP) and of drugs that have PCP-like actions (i.e., dexoxadrol, LY 154716 and cyclazocine).
(4) The effects of several neurotransmitters on prostaglandin (PG) D2-induced cataleptic behavior in rats were investigated by the high bar test.
(5) These results suggest that the antagonistic interaction of MJ-13980 at central DA receptors is not associated with the production of cataleptic behavior.
(6) Bilateral electrolytic lesions of caudate nucleus were observed to potentiate the cataleptic response, and to prevent the muscular rigidity produced by intracerebroventricular injection or infusion of dermorphin.
(7) The tetrapeptide produced obvious cataleptic status with plastic rigidity of skeletal muscles.
(8) The incidences of cataleptic behavior were 20% and 100% at doses of 2 nmol and 50 nmol of PG D2, respectively.
(9) In the decorticated rats the cataleptic and analgesic effects of beta-endorphin were markedly enhanced.
(10) Therefore, the bandage does indeed appear to inhibit the kinesthetic mechanisms that maintain head support in labyrinthectomized cataleptic rats.
(11) It was found that the increased cataleptic action of thioridazine (20 mg per kg), during radiation disease was inhibited ater metanabol premedication.
(12) In chronic experiments on cats the background activity of 272 neurons of the ventrolateral thalamic nucleus was registered extracellularly before and after the systemic injection of haloperidol and droperidol (neuroleptics) in cataleptic doses.
(13) Depletion of forebrain noradrenaline by intracerebral injection of 4 micrograms of 6-hydroxydopamine into the fibres of the dorsal noradrenergic bundle was found to block the cataleptic effects of the muscarinic cholinergic agonist arecoline and to potentiate the locomotor stimulant effects of the muscarinic cholinergic blocker scopolamine.
(14) Although both preparations exhibited exaggerated bracing responses when pushed, the LH rats acted in a non-cataleptic manner when pushed backward by the head; they retreated backward.
(15) The haloperidol-induced cataleptic behavior was reduced dose-dependently after oral treatment with aspirin, a cyclooxygenase inhibitor.
(16) Opiate B-receptors are responsible for the analgesic, antitussive, cataleptic, respiratory depressant and hypotensive effects of the opiates.
(17) Enhancement of the opioid cataleptic response was not due to changes in the availability of the drugs in the brain.
(18) An administration of p-chlorophenylalanine, an irreversible inhibitor of TPH, decreased the duration of freezing in cataleptic rats.
(19) The results support the hypothesis that the cataleptic response to cannabinoids is mediated by gamma-aminobutyric acid.
(20) CBA mice were found to be different from those of other strains both by the highest percent of cataleptics (56%) and by the highest duration of immobility.