(n.) Connection of links or union of parts, as in a chain; a regular or connected series. See Concatenation.
Example Sentences:
(1) A tabulation is given of the polynomials for all possible stereoisomers of many of the knotted and catenated forms that are found in DNA.
(2) We present a unified model for the relaxation, catenation, and knotting reactions of topoisomerase I in which the enzyme induces a break in a single-stranded region, but bridges that break with covalent and noncovalent interactions and allows passage of one duplex or single-stranded DNA segment.
(3) Unlike Escherichia coli topoisomerase I (omega), catenation by the HeLa topoisomerase I is not stimulated by gapped circles.
(4) Both the relaxation and the catenation reaction exhibit a salt optimum at 130 mM NaCl.
(5) Our findings suggest the need for closer examination for HPV episomal catenation in other cervical carcinoma cell lines as well as in primary carcinoma tissues of the uterine cervix and the anogenital tract.
(6) At low concentrations of Topo I (sufficient to confer specificity to the replication system for DNA templates containing a ColE1-type origin of DNA replication), the major products of the replication reaction were: multigenome-length, linear, double-stranded DNA molecules (an aberrant product); multiply interlinked, catenated, supercoiled DNA dimers; and a last Cairns-type replication intermediate.
(7) The increase in the number of TR in progeny episomes indicates that linear DNA is produced from concatameric replicative intermediates rather than from amplified catenated circular intermediates.
(8) Crude extracts and partially purified fractions contain an aggregating factor that can substitute spermidine in catenating reactions.
(9) Upon centrifugation of gently lysed T. cruzi cells through a sucrose gradient, a free DNA fraction was shown to contain catenated dimers and knotted DNA structures.
(10) The mitochondrial DNA of trypanosomes is organized as a network of catenated circular DNA molecules called the kinetoplast.
(11) Unexpectedly, deletion of the first Zn finger, a point mutation in the Zn-catenation site in the first finger, or one in the steroid-specificity domain at the base of the first finger converted GR into a dexamethasone-responsive activator that enhanced basal and interleukin 1-induced IL-6 promoter function.
(12) The results are consistent with the idea that DNA-binding sites are fixed on the scaffold and mediate catenation of bound DNA circles by holding them in close proximity to each other.
(13) Ellipticine in particular produced these catenated dimers rapidly and efficiently.
(14) Consequently, the relaxation activity was almost the same between the RL and AH fractions, whereas the catenation activity was much higher in the AH fraction.
(15) For a DNA circle nicked at a unique location, the efficiency of DNA breakage opposite the nick correlates with the rate of catenation.
(16) This procedure liberates linearized minicircle molecules from network catenation, distributing them throughout the lysate, and allowing a small aliquot of the original lysate to be analyzed by PCR amplification.
(17) In vitro, the complexity of catenated products was linearly proportional to substrate supercoil density.
(18) These newly synthesized strands were not part of two catenated interlocked SV40 monomers suggesting that the block occurred prior to the final ligation reaction.
(19) Hypertonic medium appeared to inhibit both DNA unwinding in the termination region and separation of catenated dimers.
(20) MtDNA (monomeric and catenated dimeric forms) in transformed and uninfected CEF replicate by displacement synthesis.
Chain
Definition:
(n.) A series of links or rings, usually of metal, connected, or fitted into one another, used for various purposes, as of support, of restraint, of ornament, of the exertion and transmission of mechanical power, etc.
(n.) That which confines, fetters, or secures, as a chain; a bond; as, the chains of habit.
(n.) A series of things linked together; or a series of things connected and following each other in succession; as, a chain of mountains; a chain of events or ideas.
(n.) An instrument which consists of links and is used in measuring land.
(n.) Iron links bolted to the side of a vessel to bold the dead-eyes connected with the shrouds; also, the channels.
(n.) The warp threads of a web.
(v. t.) To fasten, bind, or connect with a chain; to fasten or bind securely, as with a chain; as, to chain a bulldog.
(v. t.) To keep in slavery; to enslave.
(v. t.) To unite closely and strongly.
(v. t.) To measure with the chain.
(v. t.) To protect by drawing a chain across, as a harbor.
Example Sentences:
(1) We used the polymerase chain reaction (PCR) to amplify the breakpoint area of alpha-thalassemia-1 of Southeast Asia type and several parts of the alpha-globin gene cluster to make a differential diagnosis between alpha-thalassemia-1 and Hb Bart's hydrops fetalis.
(2) In addition, DDT blocked succinate dehydrogenase and the cytochrome b-c span of the electron transport chain, which also secondarily reduced ATP synthesis.
(3) The high transition enthalpy for kerasin is ascribed to a lesser accommodation of gauche conformers in the hydrocarbon chains just below the transition temperature.
(4) Mannose receptor mediated uptake by the reticuloendothelial system has been suggested as an explanation for the rapid removal of ricin A chain antibody conjugates from the circulation after their administration.
(5) We have examined overlapping octapeptides from the kappa IIIb light chain variable region and show that some framework peptides have the ability to bind aggregated IgG.
(6) The Tyr side chain had two conformations of comparable energy, one over the ring between the Gln and Asn side chains, and the other with the Tyr side chain away from the ring.
(7) The lineage and clonality of Hodgkin's disease (HD) were investigated by analyzing the organization of the immunoglobulin and T-cell receptor beta-chain (T beta) gene loci in 18 cases of HD, and for comparison, in a panel of 103 cases of B- and T-cell non-Hodgkin's lymphomas (NHLs) and lymphoid leukemias (LLs).
(8) Only those derivatives with a free amino group and net positive charge in the side chain were effective.
(9) Approximately 90% of the patients have a lambda light chain myeloma protein and almost all patients excrete Bence-Jones protein.
(10) The reducing equivalents could be donated by formate or NADH through some segment of the membrane respiratory chain.
(11) Thus there may be four types of LPS in PACI: one contains unsubstituted core polysaccharide and yields L2 on acid hydrolysis, another has short antigenic side-chains of the SR type and yields the LI fraction, while the two high molecular weight fractions are derived from core polysaccharides with different side-chains.
(12) The seve polypeptide chains investigated had generalyy similar properties; all contained two residues per molecule of tryptophan and N-acetylserine was the common N-terminal amino acid residue.
(13) Urine specimens from patient REE also contained a light chain fragment that lacked the first (amino-terminal) 85 residues of the native light chain but otherwise was identical in sequence to the light chain REE.
(14) Peptide:N-glycosidase F removed both the asparagine-linked oligosaccharide chains of ricin B-chain in the absence of lactose.
(15) When labelled long-chain fatty acids or glycerol were infused into the lactating goat, there was extensive transfer of radioactivity into milk in spite of the absence of net uptake of substrate by the mammary gland.
(16) In general, optimal DAGAT activity in vitro was observed when long-chain unsaturated acyl-CoAs and diacylglycerols (DAGs) containing long acyl chains were used as substrates for in vitro TAG synthesis (although 1,2-didecanoin was also very effective).
(17) The canine system allows quantitative separation of native heme containing alpha and beta chains which recombine to for tetrameric hemoglobin with normal functional properties (n = 2.17).
(18) The product of this enzymatic hydrolysis was F420 with one less glutamic acid in the side chain.
(19) The present study deals with 832 ossicular chain reconstruction procedures performed in 655 patients from January 1975 to December 1985.
(20) On the other hand, if we correct for the population of HMM with degraded light chain 2, the difference in the binding constants in the presence and absence of Ca2+ may be as great as 5-fold.