(n.) The anterior, and in man the larger, division of the brain; the seat of the reasoning faculties and the will. See Brain.
Example Sentences:
(1) Moderately higher GLUT3 mRNA levels were detected in the parietal lobe of the cerebrum, hippocampus, and cerebellum than the levels of GLUT1 transcripts.
(2) Protein kinase II activity was localized predominantly in the 100,000g particulate fraction of cerebrum and testis, in the supernatant fraction of heart, liver, adrenal, and kidney, and about equally distributed between particulate and supernatant in spleen and lung.
(3) Attempts were made to characterize mitochondrial malate dehydrogenase [L-malate: NAD+ oxidoreductase, EC 1.1.1.37] (M-MDH) purified from bovine cerebrum and to elucidate the mechanisms responsible for inhibition of the enzymic activity by Ag+.
(4) This hereditary lipidosis is characterized pathologically by demyelination, loss of axons, and replacement of the white matter of the caudal cerebrum by a glial scar.
(5) No significant difference between normal and thyroidectomized rats was revealed in this respect on both the cerebrum and brain stem throughout the experimental periods.
(6) Detergent-unextractable structures of synaptic plasma membrane of rat cerebrum were observed by whole mount electron microscopy.
(7) A coronal section of the cerebrum clearly demonstrated a large tumor in the left frontal lobe with small mass in the right frontal lobe (Fig.
(8) In this retrospective study the findings of visual acuity, visual field and papillae of 204 patients operated on the cerebrum were determined and the significance of the morphological factors (position and size of the defect of the cerebral parenchyma, extent of the cerebral ventricles, degree of the cortical atrophy, influence of dignity) for the persisting ophthalmological deficiency phenomena was pointed out.
(9) Primary cultures of mixed glial cells from rat cerebrum and cerebellum, purified oligodendrocytes and astrocytes, as well as two glial tumor cell lines were screened for the expression of glucocorticoid receptors using a mouse monoclonal antibody directed against rat liver GR (BuGR-2).
(10) The IC50 values obtained for these antagonists to block the carbachol-induced PPI turnover cycle in the synaptosomes from the cerebrum were close to the values obtained for the displacement of 3H-QNB binding to the same preparation, and were far away from those values obtained in the synaptosomes from the cerebellum.
(11) Dissociated explants of 8-day-old embryonic chick cerebrum were cultured for up to 18 days.
(12) Electrophysiological studies also revealed the involvements of cerebrum and brain stem.
(13) The ratio of albumin concentration in the cerebellum or in the cerebrum to that in the plasma 2 h after the injection, hereinafter termed the relative albumin level (RA), was calculated and used as a criterion for the albumin transfer.
(14) It is known that the copper concentration and copper-containing enzyme activity are low in cerebrum of mottled mice as well as of patients with Menkes' disease.
(15) In the same animals the calcium content in the cerebrum was independent of plasma calcium between 0.5 and 1.5 mM but rose at higher plasma concentrations.
(16) Low levels of CGRP (less than 500) were detected in the cerebrum, subcortical nuclei and cerebellum.
(17) It was speculated that the CTBP has a specific function in cerebrum at the time of birth although the action of the CTBP is not certain.
(18) The ontogeny of presynaptic elements of GABAergic neurons has been studied in the cerebrum of the chick embryo both in vivo and in vitro.
(19) Gross and histopathologic lesions of the cerebrum included an extensive necrotic cavitation within one cerebral hemisphere, disruption and rarefication of the subcortical white matter, prominent perivascular hemorrhage, and some mononuclear cell perivascular cuffing.
(20) The RA in both the cerebellum and the cerebrum decreased with age, but plateaued between days 28 and 70.
Forebrain
Definition:
(n.) The anterior of the three principal divisions of the brain, including the prosencephalon and thalamencephalon. Sometimes restricted to the prosencephalon only. See Brain.
Example Sentences:
(1) We assessed changes in brain water content, as reflected by changes in tissue density, during the early recirculation period following severe forebrain ischemia.
(2) To study these changes more thoroughly, specific monoclonal antibodies of the A and B subunits of calcineurin (protein phosphatase 2B) were raised, and regional alterations in the immunoreactivity of calcineurin in the rat hippocampus were investigated after a transient forebrain ischemic insult causing selective and delayed hippocampal CA1 pyramidal cell damage.
(3) The analogy with infant sleep patterns and results of studies of brain function in narcoleptics suggest that forebrain inhibitory processes are more important in narcoleptic symptomology than is brainstem dysfunction.
(4) Neural plate damage, expressed during a critical period of forebrain development, was evaluated 48 h post-insonation.
(5) This result contraindicates a general permissive-requisite role for forebrain NE for the mammalian brain's plasticity during its critical periods.
(6) Key findings include a progressive degeneration of these cholinergic neurons characterized by the formation of immunoreactively atypical NFT, the loss of intraneuronal lipofuscin, a lack of senile plaque and beta-amyloid deposition within the basal forebrain, and end-stage gliosis without residual extracellular NFT.
(7) The hypothalamus is a most complex part of the CNS having rich interconnections with forebrain, limbic and brainstem structures.
(8) Results suggest that the locomotor activating effects of CRF may be due to an activation of CRF receptors in the ventral forebrain, a region rich in CRF cell bodies and projections.
(9) Sixty days after 5,7-DHT administration, immunoreactive serotonin in the forebrain, particularly the suprachiasmatic nuclei and intergeniculate leaflets, was severely depleted in 16 animals, moderately depleted in four and only slightly affected in four.
(10) Twelve-hour polygraph recordings were made before and at various intervals after basal forebrain damage in a total of eight cats.
(11) Impairments of cognition and memory in AD result from disease of neurons in a number of regions, including brainstem, basal forebrain, amygdala, hippocampus, and neocortex.
(12) Patients with bilateral forebrain disease may commonly manifest the syndrome of pathologic laughing and weeping.
(13) Ovariectomized (OVXed) animals were implanted with chronic cannulas in the basal forebrain.
(14) Thus, neurons of the habenula and interpeduncular nucleus are under the direct and indirect influence of septal neurons within the limbic forebrain circuit.
(15) A detailed description is offered on supply of the nucleus preopticus medialis, lateralis, suprachiasmatis and periventricularis, as well as of the nucleus interstitialis striae criminalis and of the preoptic portion of the medical forebrain bundle.
(16) The regional distribution of forebrain neurons expressing preprocholecystokinin (preproCCK) mRNA was examined using in situ and blot hybridization analysis.
(17) Some LC neurones were activated trans-synaptically by stimulation of those forebrain sites which received axonal projections from LC.
(18) Other antidromically activated neurons in the vasodepressor region may be inhibitory vasomotor cells with a function relatively independent of baroreceptor inputs, or they may be A1 catecholamine neurons, with axons passing through the rostral medulla en route to the forebrain.
(19) Fewer, but still ample numbers, of SP-reactive axons are present also in the ventral tegmental and retrorubral areas of the midbrain tegmentum and in the ventral pallidum of the basal forebrain, but only sparse ME-reactive axons are present in these areas.
(20) 5-HT containing terminals and fibers also were observed in the mesencephalon and appeared to run rostrally in the medial part of the medial forebrain bundle.