(1) [3H]cyclohexyladenosine (CHA) and [3H]PN200-110 were used to label muscarinic and adenosine A1 receptors and L-type calcium channels, respectively.
(2) Since ADO is a metabolic substrate and a nonselective receptor agonist, while CHA is A1-selective and a poor substrate for cellular uptake, neither A2 activation nor cellular uptake altered expression of the A1 effect of exogenous ADO.
(3) R-PIA, CHA and NECA inhibited contraction in both preparations.
(4) In contrast to the relative consistency of the patterns of 3H-CHA binding in these species, 5'-nucleotidase exhibited wide variations in both the absolute amount of activity and its localization.
(5) Concomitant measurement of [3H]-CHA binding in the mesencephalic reticular formation was also carried out in order to explore the neurochemical basis of the development of tolerance.
(6) For aortic relaxation the analogues exhibited the following rank order of potency: NECA greater than adenosine greater than 2-CA greater than R-PIA greater than CHA.
(7) Regulation of c-fos protooncogene activity in rat embryonal fibroblasts (REF), E1Aad5-immortalized REF cells, and E1Aad5 + cHa-ras transformed REF cells has been investigated.
(8) Although more studies are needed, a recent report of potential utilization of nonstimulated oocytes for donor programs as well as IVF-cryopreservation was a promising new development (Cha et al.
(9) 3H-CHA and 3H-NECA binding sites are concentrated in layers 1-3 and upper layer 5 in the visual cortex of adult cats.
(10) In this paper, CDDP-CHA tried to apply for experimental bone and soft tissue sarcoma.
(11) The effect of toxin on adenosine receptors was also evaluated by measuring binding of the adenosine agonist cyclohexyladenosine (CHA).
(12) "All those vuvuzuelas must be interfering with Cha Bum-Kun's ability to remote control his robot creation - er, son - Cha Du-ri," suggests Angela K, a South Korean expat in the US.
(13) The R(-)- and S(+)-enantiomers of N6-(2-phenylisopropyl)adenosine (R-PIA and S-PIA respectively), N6-cyclohexyladenosine (CHA) and 2-chloroadenosine (CADO) caused contractions at low concentrations (0.05-2.0 microM), whereas at higher concentrations, relaxation resulted.
(14) Circular harmonic averaging (CHA), a novel, reference-independent averaging method developed by W. Kunath and H. Sack-Kongehl [1989) Ultramicroscopy 27:171-184) allows analyzing images of single molecules of the receptor in its native membrane-bound state.
(15) An unexpected finding was that R-PIA, 2-CA and CHA all induced contractions at concentrations lower than were required for relaxation, giving a biphasic dose-response curve.
(16) Concentrations to achieve half-maximum responses were 92.5 nM for 2-ClAdo, 39 nM for CHA, and 107 nM for NECA.
(17) Moreover, the addition of guanylyl-5'-imidodiphosphate, a GTP analogue, to the incubation medium reduced CHA binding by the same order of magnitude whether rats were given saline or bicuculline, suggesting that additional adenosine A1 receptors are also functionally linked to G proteins.
(18) Hippocampi from theophylline-treated animals showed a significantly greater number of [3H]CHA binding sites (apparent Bmax; 125% of control, P less than 0.05), without a significant change in binding affinity, and were more sensitive than controls to the inhibitory effects of adenosine on the population spike response.
(19) Both genes were shown to be present in haploid embryos and have been isolated from a genomic library, the exons and deduced amino acid sequences of which are presented here (salmon CHA and CHB).
(20) Accordingly, the peak in adenosine receptor binding, using (-)[125I]iodo-N6-hydroxyphenyl-isopropyladenosine as the radioligand, coincided with CHA-inhibitable adenylate cyclase activity.
Chad
Definition:
(n.) See Shad.
Example Sentences:
(1) That is happening not only in Brazil, but also in poorer cotton-producing countries such as Burkina Faso, Mali, Benin and Chad.
(2) Out of 4176 sera from asymptomatic adults originating from Chad, equatorial Guinea and Gabon tested for HIV-1 antibodies, 146 (3.5%) were positive by an enzyme immunoassay (EIA).
(3) Abaifouta, who is now president of the Hissène Habré victims association in Chad, spends his days campaigning on behalf of others like him; tireless in his efforts to bring justice, he has worked closely with Human Rights Watch and other groups.
(4) On Wednesday he will travel to Chad and Niger, whose troops help fight Boko Haram, said his spokesman, Garba Shehu.
(5) The aim is to secure the capital Bangui and the principal routes towards neighbouring Cameroon and Chad.
(6) In a summit in Paris last week, the west African nations of Cameroon, Chad and Niger agreed to each contribute a battalion to form a border patrol troop based around the arid Sahelian belt, large swaths of which have fallen under the control of Islamist terrorists in recent years.
(7) It also was recovered from El Bur and one with similar microscopic characters has been seen in Chad and also in "territoire français des Afars et des Issas".
(8) Spurs made light of their lack of recognised strikers, with Chadli and Carroll doing the damage from wide midfield and helping them to a comfortable victory.
(9) Chad Abram runs for three yards for a first down, and FSU keep driving, and Winston throws again to Benjamin, 24 yards to the Auburn 29, and that's very much another first down.
(10) Funding for programmes in Chad has been particularly difficult to secure.
(11) The reservoir cannula Oxymizer Pendant (Chad-Therapeutics Inc.) is a nasal prong system incorporating a pendant reservoir which stores oxygen during expiration and delivers it as a bolus at the onset of inspiration.
(12) Nacer Chadli was another who might have won it for the home team but this was not a day for ruthlessness.
(13) Many young people have never known a time when Habré was in Chad – he fled the country shortly after Idriss Déby's forces progressed westwards from Iriba, and eventually sought refuge in Senegal.
(14) Chad Griffin, president of Human Rights Campaign, said, in a video posted on the organisation's website : "Years from now, we'll remember this election day as the most historic and the most important in the LGBT community."
(15) "We can say there is a crisis already, just by the number of cases of malnutrition which we're dealing with in hospitals from Chad to Burkina Faso to Mali," said Alvaro Pascual, Sahel desk officer for Action Against Hunger .
(16) Few Americans may have heard of Hissène Habré, but the US government was intimately involved in his rise to power in Chad in 1982.
(17) A regional military coalition of Nigeria, Niger, Chad and Cameroon has claimed a series of major victories against Boko Haram since launching sweeping offensives against the terrorist group in February.
(18) Seattle had already opened the scoring, Chad Barrett converting from close range after Lovel Palmer was unable to clear a Kenny Cooper cross.
(19) The recently appointed captain Younès Kaboul, Emmanuel Adebayor, Mousa Dembélé and Nacer Chadli have also stayed at home.
(20) "Niger and Chad are the two countries with the largest crop deficits and there are already reports of a 90% reduction in cereal trades entering at some border posts in Nigeria," said Steve Cockburn of Oxfam West Africa .