(1) [3H]cyclohexyladenosine (CHA) and [3H]PN200-110 were used to label muscarinic and adenosine A1 receptors and L-type calcium channels, respectively.
(2) Since ADO is a metabolic substrate and a nonselective receptor agonist, while CHA is A1-selective and a poor substrate for cellular uptake, neither A2 activation nor cellular uptake altered expression of the A1 effect of exogenous ADO.
(3) R-PIA, CHA and NECA inhibited contraction in both preparations.
(4) In contrast to the relative consistency of the patterns of 3H-CHA binding in these species, 5'-nucleotidase exhibited wide variations in both the absolute amount of activity and its localization.
(5) Concomitant measurement of [3H]-CHA binding in the mesencephalic reticular formation was also carried out in order to explore the neurochemical basis of the development of tolerance.
(6) For aortic relaxation the analogues exhibited the following rank order of potency: NECA greater than adenosine greater than 2-CA greater than R-PIA greater than CHA.
(7) Regulation of c-fos protooncogene activity in rat embryonal fibroblasts (REF), E1Aad5-immortalized REF cells, and E1Aad5 + cHa-ras transformed REF cells has been investigated.
(8) Although more studies are needed, a recent report of potential utilization of nonstimulated oocytes for donor programs as well as IVF-cryopreservation was a promising new development (Cha et al.
(9) 3H-CHA and 3H-NECA binding sites are concentrated in layers 1-3 and upper layer 5 in the visual cortex of adult cats.
(10) In this paper, CDDP-CHA tried to apply for experimental bone and soft tissue sarcoma.
(11) The effect of toxin on adenosine receptors was also evaluated by measuring binding of the adenosine agonist cyclohexyladenosine (CHA).
(12) "All those vuvuzuelas must be interfering with Cha Bum-Kun's ability to remote control his robot creation - er, son - Cha Du-ri," suggests Angela K, a South Korean expat in the US.
(13) The R(-)- and S(+)-enantiomers of N6-(2-phenylisopropyl)adenosine (R-PIA and S-PIA respectively), N6-cyclohexyladenosine (CHA) and 2-chloroadenosine (CADO) caused contractions at low concentrations (0.05-2.0 microM), whereas at higher concentrations, relaxation resulted.
(14) Circular harmonic averaging (CHA), a novel, reference-independent averaging method developed by W. Kunath and H. Sack-Kongehl [1989) Ultramicroscopy 27:171-184) allows analyzing images of single molecules of the receptor in its native membrane-bound state.
(15) An unexpected finding was that R-PIA, 2-CA and CHA all induced contractions at concentrations lower than were required for relaxation, giving a biphasic dose-response curve.
(16) Concentrations to achieve half-maximum responses were 92.5 nM for 2-ClAdo, 39 nM for CHA, and 107 nM for NECA.
(17) Moreover, the addition of guanylyl-5'-imidodiphosphate, a GTP analogue, to the incubation medium reduced CHA binding by the same order of magnitude whether rats were given saline or bicuculline, suggesting that additional adenosine A1 receptors are also functionally linked to G proteins.
(18) Hippocampi from theophylline-treated animals showed a significantly greater number of [3H]CHA binding sites (apparent Bmax; 125% of control, P less than 0.05), without a significant change in binding affinity, and were more sensitive than controls to the inhibitory effects of adenosine on the population spike response.
(19) Both genes were shown to be present in haploid embryos and have been isolated from a genomic library, the exons and deduced amino acid sequences of which are presented here (salmon CHA and CHB).
(20) Accordingly, the peak in adenosine receptor binding, using (-)[125I]iodo-N6-hydroxyphenyl-isopropyladenosine as the radioligand, coincided with CHA-inhibitable adenylate cyclase activity.
Chat
Definition:
(v. i.) To talk in a light and familiar manner; to converse without form or ceremony; to gossip.
(v. t.) To talk of.
(n.) Light, familiar talk; conversation; gossip.
(n.) A bird of the genus Icteria, allied to the warblers, in America. The best known species are the yellow-breasted chat (I. viridis), and the long-tailed chat (I. longicauda). In Europe the name is given to several birds of the family Saxicolidae, as the stonechat, and whinchat.
(n.) A twig, cone, or little branch. See Chit.
(n.) Small stones with ore.
Example Sentences:
(1) The cDNA insert, which contained a 728-amino acid coding region for ChAT, was used for immunizing rabbits.
(2) The Ca2+ agonist Bay K 8644 (1 microM) potentiated the effects of elevated K+ on both ChAT and TOH.
(3) You could also chat to local estate agents to get an idea of what kind of extension, if any, would appeal to buyers in your area.
(5) ChAT activities of the iris, adrenal gland, and superior cervical ganglion were similar in all groups.
(6) Vladimir Putin brushed off complaints of election fixing during his annual televised live chat with the nation on Thursday , but behind the scenes his lieutenants are anxiously plotting how to quell rising discontent.
(7) I tweet, check Facebook, chat with friends, keep in touch with colleagues, check in using Foursquare, use it to check work emails from home and organise notes using Evernote.
(8) In an interview on Jonathan Ross's chat show on ITV1 in September 2011, Adele had said: "I'm going back in the studio in November, fingers crossed.
(9) Since the striatal response began to be detectable at a similar concentration as that required for the full maintenance or restoration of ChAT and NGF receptor positivity it could be seen as an unwanted side-effect.
(10) In the ganglion cell layer, 40% of the cells were immunoreactive for choline acetyltransferase (ChAT); these cells were very homogeneous in size, had an average diameter of 12.6 microns, and appeared to represent a single class of cholinergic amacrine.
(11) There was also local reduction in choline acetyltransferase (ChAT) activity and significant losses of 55-kDa protein in the soluble fraction and of 50-kDa protein in myelin and synaptosomal fractions in the hippocampi of colchicine-lesioned rats.
(12) Cholinergic expression, as assessed by activity of choline acetyltransferase (ChAT), responded differentially to neuropeptide treatment.
(13) I drive past buildings that I know, or assume, to house bedsits, their stucco peeling like eczema, their window frames rattling like old bones, and I cannot help myself from picturing the scene within: a dubious pot on an equally dubious single ring, the female in charge of it half-heartedly stirring its contents at the same time as she files her nails, reads an old Vogue, or chats to some distant parent on the telephone.
(14) Frankly, an unconfrontational, off-the-high-horse chat is in order but it's not coming soon.
(15) Intraocular injections of colchicine did not result in the appearance of a population of ChAT-immunoreactive neurons in the ganglion cell layer.
(16) In addition, ChAT activity was enhanced by anti-Met, and TH activity by both anti-Met and naloxone.
(17) In both species, ChAT-IR somata in the GCL outnumbered those in the INL at all retinal locations.
(18) The neuropil of this nucleus was free from any distinctly ChAT-positive structures.
(19) On the train journey to court I will usually chat to the family to try and help them remain calm before the day ahead.
(20) Since arriving in Moscow, Snowden has been keeping late and solitary hours – effectively living on US time, tapping away on one of his three computers (three to be safe; he uses encrypted chat, too).