(1) [3H]cyclohexyladenosine (CHA) and [3H]PN200-110 were used to label muscarinic and adenosine A1 receptors and L-type calcium channels, respectively.
(2) Since ADO is a metabolic substrate and a nonselective receptor agonist, while CHA is A1-selective and a poor substrate for cellular uptake, neither A2 activation nor cellular uptake altered expression of the A1 effect of exogenous ADO.
(3) R-PIA, CHA and NECA inhibited contraction in both preparations.
(4) In contrast to the relative consistency of the patterns of 3H-CHA binding in these species, 5'-nucleotidase exhibited wide variations in both the absolute amount of activity and its localization.
(5) Concomitant measurement of [3H]-CHA binding in the mesencephalic reticular formation was also carried out in order to explore the neurochemical basis of the development of tolerance.
(6) For aortic relaxation the analogues exhibited the following rank order of potency: NECA greater than adenosine greater than 2-CA greater than R-PIA greater than CHA.
(7) Regulation of c-fos protooncogene activity in rat embryonal fibroblasts (REF), E1Aad5-immortalized REF cells, and E1Aad5 + cHa-ras transformed REF cells has been investigated.
(8) Although more studies are needed, a recent report of potential utilization of nonstimulated oocytes for donor programs as well as IVF-cryopreservation was a promising new development (Cha et al.
(9) 3H-CHA and 3H-NECA binding sites are concentrated in layers 1-3 and upper layer 5 in the visual cortex of adult cats.
(10) In this paper, CDDP-CHA tried to apply for experimental bone and soft tissue sarcoma.
(11) The effect of toxin on adenosine receptors was also evaluated by measuring binding of the adenosine agonist cyclohexyladenosine (CHA).
(12) "All those vuvuzuelas must be interfering with Cha Bum-Kun's ability to remote control his robot creation - er, son - Cha Du-ri," suggests Angela K, a South Korean expat in the US.
(13) The R(-)- and S(+)-enantiomers of N6-(2-phenylisopropyl)adenosine (R-PIA and S-PIA respectively), N6-cyclohexyladenosine (CHA) and 2-chloroadenosine (CADO) caused contractions at low concentrations (0.05-2.0 microM), whereas at higher concentrations, relaxation resulted.
(14) Circular harmonic averaging (CHA), a novel, reference-independent averaging method developed by W. Kunath and H. Sack-Kongehl [1989) Ultramicroscopy 27:171-184) allows analyzing images of single molecules of the receptor in its native membrane-bound state.
(15) An unexpected finding was that R-PIA, 2-CA and CHA all induced contractions at concentrations lower than were required for relaxation, giving a biphasic dose-response curve.
(16) Concentrations to achieve half-maximum responses were 92.5 nM for 2-ClAdo, 39 nM for CHA, and 107 nM for NECA.
(17) Moreover, the addition of guanylyl-5'-imidodiphosphate, a GTP analogue, to the incubation medium reduced CHA binding by the same order of magnitude whether rats were given saline or bicuculline, suggesting that additional adenosine A1 receptors are also functionally linked to G proteins.
(18) Hippocampi from theophylline-treated animals showed a significantly greater number of [3H]CHA binding sites (apparent Bmax; 125% of control, P less than 0.05), without a significant change in binding affinity, and were more sensitive than controls to the inhibitory effects of adenosine on the population spike response.
(19) Both genes were shown to be present in haploid embryos and have been isolated from a genomic library, the exons and deduced amino acid sequences of which are presented here (salmon CHA and CHB).
(20) Accordingly, the peak in adenosine receptor binding, using (-)[125I]iodo-N6-hydroxyphenyl-isopropyladenosine as the radioligand, coincided with CHA-inhibitable adenylate cyclase activity.
Chav
Definition:
Example Sentences:
(1) Starkey was in a heated discussion with Owen Jones, author of Chavs: the Demonisation of the Working Class, when he made his remarks during a discussion hosted by Emily Maitlis that also included the writer Dreda Say Mitchell.
(2) "What has happened is that the substantial section of the chavs that you wrote about have become black.
(3) A classic example, she believes, is Little Britain, in which David Walliams blacked up to play the character of Desiree, an obese black woman, and in which so-called "chavs" are ridiculed.
(4) But the one that really jumped out was of a chav-themed school disco: all these rosy-cheeked, foppish-looking public schoolkids dressed in baseball caps and Adidas tracksuits.
(5) Johnson tells the Radio Times that she didn't know that fat people ("classic chavs") could be hungry, until she saw their empty cupboards and their food budget (£3 a day for three people), and what it could and could not buy.
(6) I love her twice as hard for depriving a certain type of viewer of the chaotic chavs-on-tour spectacle they might have been expecting by taking entirely normal holidays and considering sound financial options.
(7) Discussion of the moral deficiency of benefit claimants has long been a substitute for political and economic debate, asylum-seeker is a dirty word, and "chav" is a word that no one wants applied to them.
(8) Jones's Chavs, Andy Merrifield's Magical Marxism, Laurie Penny's collection of her writing Penny Red and Nicholas Shaxson's exposé of tax havens Treasure Islands complete the lineup.
(9) Unusually for the comedy chav character – sadly every soap has one – Beth has been furnished with the requisite parenting skills to clock when something's up with her Craigy.
(10) The headline inside was "Future Bling of England"; the strapline screamed, "Wills wears Chav Gear in Army Snap."
(11) The shortlist Counterpower: Making Change Happen by Tim Gee Debt: The First 5,000 Years by David Graeber Tweets from Tahrir: Egypt's Revolution as it Unfolded, in the Words of the People Who Made It edited by Nadia Idle and Alex Nunns Chavs: The Demonization of the Working Class by Owen Jones Magical Marxism: Subversive Politics and the Imagination by Andy Merrifield Penny Red: Notes from the New Age of Dissent by Laurie Penny Treasure Islands: Tax Havens and the Men who Stole the World by Nicholas Shaxson
(12) Class hatred has been siphoned off on to chavs, scroungers, benefit fraudsters, single mothers, all the new untouchables, so that the architects of austerity can justify their cruelty.
(13) It hardly ever has a scandal – the biggest was when a group of 12-year-olds got drunk on vodka – and it is reputed, probably wrongly, to have originated "chav" as a snooty term for the less eligible young men of the town ("Cheltenham average").
(14) And in popular culture, stereotypes that had been given new life in the 1980s eventually went nuclear: the mid-to-late New Labour period, let us not forget, was the era of Little Britain’s council-estate grotesque Vicky Pollard , the hairstyle maligned as the council-house facelift, and the bundling-up of council housing in the same dread category as “chavs” and welfare scroungers.
(15) Over two pages built around a snap of 30 trainee officers at Sandhurst, yesterday's Sun gleefully recounted how the heir to the throne "joined in the fun as his platoon donned chav-themed fancy dress to mark the completion of their first term".
(16) The “mix”, even when it happened, was a mix of the mutually hostile – search for the Greenwich Millennium Village online, to find a host of complaints by rich residents at the fact that sundry “chavs” and “scum” have ended up residing in their stunning luxury living solution.
(17) Now the people that bug me every day are cab drivers and chavs.
(18) His perusal of the entertainment currently offered to undergraduates has only confirmed that the so-called "chav bop" - a disco where you dress up as a working-class person - is an immovable fixture not only at public schools, but also throughout Oxford's colleges.
(19) They want us looking suspiciously and disdainfully in the direction of marginalised individuals; "chavs", "immigrants" and "gays," not in the direction of the institutions who actually damage our society – banks, corporations and the media.
(20) They want to see the back of these TV chavs so they can be left with their Poliakoff and their Potter (as well as their Big Brothers and Embarrassing Illnesses and all their "TV heaven", slumming it choices, obviously) and be served a TV which is essentially much more ... them.