(1) The effect of various fractions of chalone--containing preparation from ascyte Ehrlich's tumour obtained by high performance liquid chromatography (HPLC) on mitotic activity and DNA synthesis in the tumour has been studied.
(2) It was also found that the maximum number of dividing cells was at the wound edge in the group wounded at 09.00 h, which also agrees with the chalone concept.
(3) Thus the circadian rhythms and S-phase lengths of the test tissues need to be considered when experiments are performed with chalones.
(4) We show here that in our granulocytic and lymphocytic chalones polyamines, either free or bound, are not responsible for the inhibitory effects of the preparation.
(5) Some definite regularities were revealed in the change of the power of linkage among the cells of liver parenchyma after the disturbance of its innervation and chalones affected.
(6) A "negative feedback" mechanism of control with chalone, a tissue-specific, species-nonspecific inhibitor of mitosis, has been suggested by Bullough and Laurence.
(7) Theophylline (an inhibitor of cyclic nucleotide phosphodiesterase) or epidermal chalone inhibited mitoses and enhanced KG production.
(8) However, it is evident that the tumour cells react less than the epidermis to both the G1 and the G2 chalone, and thus the findings of this study do not provide any evidence against the theory that epidermoid transplanted tumours are less sensitive to epidermal chalones than normal tissue of the same histogenetic origin.
(9) The model has been developed to take into account the chalone mechanism of hemopoiesis regulation.
(10) It is suggested that chalones be used both as regulators of cell multiplication and as markers of histogenesis.
(11) It is based on the theory of chalone regulation of hematopoiesis.
(12) Choleragenoid did not block inhibition of mitogen stimulation by a lymphocyte chalone preparation indicating that a different mechanism may be involved with the chalone.
(13) It was prepared from a bovine spleen acetone powder and found to be associated partly with high molecular weight carriers in the form of an active complex characterized previously as part of a 'lymphoid chalone' fraction.
(14) Here there was initially a depression of the mitotic rate and a low concentration of G2 chalone.
(15) In contrast to the G1-chalone preparation, aphidicolin, a potent inhibitor of DNA polymerase alpha, clearly shows S-phase-specific inhibition.
(16) Chalone treatment also resulted in an enhancement of erythropoiesis and megakaryopoiesis, and in phenomena some of which were totally unexpected, such as immunostimulation and a remarkable resistance to bacterial infections in the presence of extreme granulocytopenia.
(17) To explain these observations, it is assumed that the epidermal stem cell population is heterogeneous consisting of G1 chalone-sensitive and G1 chalone-insensitive cells.
(18) However, the titers of erythropoietin and medium molecules rose whereas the titer of erythrocytic chalones was reduced.
(19) Using a recently developed method of culturing T-lymphocyte colonies in agar-containing capillary tubes, the capacity of three different lymphoid extracts with lymphocyte chalone (LC) activity to inhibit colony growth was demonstrated.
(20) An additional advantage is that the capillaries provide a basis for a simple and reliable assay system for determining regulatory factors of lymphocyte proliferation (including chalones).
Soledad
Definition:
Example Sentences:
(1) Documentary maker Soledad O’Brien told The Wrap: “They are trying to do the same thing [as the civil rights movement].
(2) Back to article (2) He spent most of the 1960s behind bars for armed robbery and drug offences, including spells in the three most terrifying prisons in California's state penitentiary system, Tracy (1963-65), San Quentin (1965-68), and Soledad (1968-69).
(3) • 1425 South Via Soledad (+1 760 327 4970, alexander-inn.com ); one-bedroom villas from $140 The Horizon Horizon, Palm Springs Like the Del Marcos (below), the recently restored Horizon was designed by influential mid-century modern architect William F Cody , and to the credit of the owners (who come from Oregon), the interiors are uncluttered and simple to make the most of the property's clean lines and maximise that sense of spatial connection to the San Jacinto mountains and the big desert sky.
(4) He is survived by Chantal and three children – Santiago, Soledad and Natalia – from a previous relationship.