(n.) A venereal sore or ulcer; specifically, the initial lesion of true syphilis, whether forming a distinct ulcer or not; -- called also hard chancre, indurated chancre, and Hunterian chancre.
Example Sentences:
(1) Venereal Disease Research Laboratories (VDRL) and Treponema pallidum hemagglutination (TPHA) tests became positive during hospitalization, and dark-field examination was positive for Treponemas, thus allowing the diagnosis of chancre of the rectum.
(2) Provided goats were immunized, it was found that the chancre reaction could be used to distinguish different populations of T. congolense.
(3) Local skin reactions (chancres) developed at the sites of inoculation with Trypanosoma evansi in rabbits and calves.
(4) Following the tsetse bite, the trypanosomes in the skin multiplied, reaching maximum numbers when the skin reaction (chancre) of the host attained its maximum size.
(5) In a preliminary study, two of four rabbits infected with human T-cell leukemia virus type I (HTLV-I) demonstrated prolonged primary chancres following superinfection with Treponema pallidum, the causative agent of syphilis.
(6) A chancre sore was infrequent in children; condylomata lata was the most frequent cutaneous lesion (80.9%).
(7) Clinically the patients with abnormal liquor developed multiple chancres, erosive papules, leukoderma, alopecia, neutrophilia; these patients had suffered from various diseases in the past.
(8) Certain types such as "chancre mou volant," however, could not be found in the present material.
(9) Expression of nine metacyclic variable antigen types (M-VATs) of Trypanosoma congolense in chancres from infected rabbits was determined using monoclonal antibodies raised against metacyclic forms of trypanosomes.
(10) After cutaneous inoculation of viable Treponema pallidum subsp pallidum into the skin of chancre-immune or previously uninfected rabbits, organisms move from perivascular connective tissue to localize extracellularly in hair follicles, erector pili muscles, and cutaneous nerves.
(11) The first symptom was a lesion, or chancre, in the genital region.
(12) A description is given of the structure of the basic cellular elements found in the chancres, particularly the plasma cells since it is in them that the main immunological processes take place.The morphology of the treponemes varies in the course of the pathological process as well as with the type of cell harbouring them.
(13) In calves, similar changes were observed although there were fewer trypanosomes present in the chancre and the cellular involvement was less extensive than that seen in the rabbit.
(14) In addition, HIV-infected rabbits demonstrate prolonged cutaneous lesions (chancres) after intracutaneous challenge with T. pallidum, the causative agent of syphilis.
(15) Sensitization and repetitive elicitation with P. acnes did not change the time of appearance or progression of syphilitic chancres after i.v or i.d.
(16) A clinical, bacteriological and serological pictures of 45 patients with chancriform pyoderma are presented, A single ulcer (92.8%), localized on genitals (91.1%) in adult males (93.3%), imitating or very similar to syphilitic primary chancre in our material was observed.
(17) A brief introduction on trypanosomiasis in ruminants and an explanation of the term chancre are followed by a discussion of a number of findings on the early pathogenesis of the disease.
(18) Local skin reactions (chancres) developed in goats at the sites of deposition, by tsetse flies, of metacyclics of Trypanosoma congolense.
(19) A case of primary tuberculous chancre of the vulva is reported.
(20) In long-standing chancres cyst-like formations with multi-layered membranes have been found.
Syphilis
Definition:
(n.) The pox, or venereal disease; a chronic, specific, infectious disease, usually communicated by sexual intercourse or by hereditary transmission, and occurring in three stages known as primary, secondary, and tertiary syphilis. See under Primary, Secondary, and Tertiary.
Example Sentences:
(1) Sera of 375 blood donors which were seropositive for syphilis were examined for antibodies against Entamoeba histolytica.
(2) The dramatic nationwide increase of primary and secondary syphilis in women has precipitated a dramatic rise in congenital syphilis.
(3) These structures were also found in the blood or spinal fluid (SF) of asymptomatic patients with both positive and negative serological tests for syphilis.
(4) These findings provide a framework for future investigations of our congenital syphilis model.
(5) Several months later, as the patient experienced relapses with cerebellar and spinal cord involvement, falsely positive tests for syphilis were found and an antibiotic treatment was given.
(6) The expression of such secondary and tertiary syphilis is commonly masked and distorted by the long-term effects of subcurative doses of antibiotics; in fact, late latent and tertiary syphilis produce symptoms and immunosuppression similar to the profile of AIDS.
(7) The CSF-TPHA test was positive in four out of 12 children, and the CSF-VDRL test was negative in all the children with active congenital syphilis.
(8) Binding of aCL in syphilis to solid phase CL was competitively inhibited by either addition of the cofactor or fluid phase CL.
(9) Serological tests for hepatitis A (HA) and B (HB), syphilis and HIV were performed on blood samples from 3 groups of homosexual men: 220 and 124 asymptomatic men being investigated in 1978 and 1980 respectively and another 98 men suffering from HA during the winter 1979-80.
(10) To evaluate the effect of ceftriaxone in treating latent syphilis or asymptomatic neurosyphilis in patients infected with the human immunodeficiency virus (HIV).
(11) Lyme borreliosis has in common features with another spirochetosis, syphilis, e.g.
(12) Compared to cases in the previous year, infectious syphilis cases among prostitutes and seasonal farm workers decreased 51.3 per cent and 26.8 per cent, respectively.
(13) A clinically manifest primary or secondary syphilis that develops during pregnancy has become an extremely rare occurrence.
(14) Beside being responsible for positivity of the VDRL test in the context of syphilis, APAB (false serological reactions for syphilis, LA, anticardiolipin antibodies) have also been detected in systemic lupus erythematosus (SLE) and lupus-like syndromes, after intake of certain drugs, and, more rarely, in a number of diseases (table I).
(15) A protocol outline for diagnosis and therapy of syphilis is included in the discussion.
(16) Cryptococcosis occurred in association with toxoplasmosis in one patient who developed syphilis in the follow-up; oligoclonal distribution of gamma globulins occurred in this case.
(17) However, the treatment failed to prevent infection in the infant, and the baby had developed signs of congenital syphilis at 10 weeks of age.
(18) The protocol was devised by first evaluating a range of kits in London using a battery of African and non-African sera and then field testing 1455 sera in Malaŵi, which included 184 sera from leprosy patients and 60 sera from syphilis patients to check for cross-reactivity.
(19) Individual sequelae are most significnat when congenital syphilis is allowed to develop due to delays in treating the pregnant woman or newborn child.
(20) There is a suggestion of a plateau having occurred in adult and congenital syphilis, possibly caused by saturation effect on the high-risk population.