(n.) The hollow bed where a stream of water runs or may run.
(n.) The deeper part of a river, harbor, strait, etc., where the main current flows, or which affords the best and safest passage for vessels.
(n.) A strait, or narrow sea, between two portions of lands; as, the British Channel.
(n.) That through which anything passes; means of passing, conveying, or transmitting; as, the news was conveyed to us by different channels.
(n.) A gutter; a groove, as in a fluted column.
(n.) Flat ledges of heavy plank bolted edgewise to the outside of a vessel, to increase the spread of the shrouds and carry them clear of the bulwarks.
(v. t.) To form a channel in; to cut or wear a channel or channels in; to groove.
(v. t.) To course through or over, as in a channel.
Example Sentences:
(1) These channels may, at least in some cases, be responsible for the generation of pacemaker depolarizations, thereby regulating firing behaviour.
(2) The influence of the various concepts for the induction of lateral structure formation in lipid membranes on integral functional units like ionophores is demonstrated by analysing the single channel current fluctuations of gramicidin in bimolecular lipid membranes.
(3) RNAs encoding a wild-type (RBK1) and a mutant (RBK1(Y379V,V381T); RBK1*) subunit of voltage-dependent potassium channels were injected into Xenopus oocytes.
(4) The dramas are part of the BBC2 controller Janice Hadlow's plans for her "unashamedly intelligent" channel over the coming months.
(5) This was unlike the action of the calcium channel blocker, cadmium, which reduced the calcium action potential and the a.h.p.
(6) Circuitry has been developed to feed the output of an ear densitogram pickup into one channel of a two-channel Holter monitor.
(7) It is concluded the decrease in cellular volume associated with substitution of serosal gluconate for Cl results in a loss of highly specific Ba2+-sensitive K+ conductance channels from the basolateral plasma membrane.
(8) Stimulation of atrial H1-receptors is suggested to directly cause an increase in Ca-channel conductance independent of intracellular cAMP content.
(9) Similarly, 50 microM D-600, a Ca+2 channel antagonist, significantly (P less than 0.01) reduced basal and 5-HETE-induced PRL release.
(10) The purpose of the present study was to analyze the effects of cromakalim (BRL 34915), a potent drug from a new class of drugs characterized as "K+ channel openers", on the electrical activity of human skeletal muscle.
(11) This promotion of repetitive activity by the introduction of additional potassium channels occurred up to an "optimal" value beyond which a further increase in paranodal potassium permeability narrowed the range of currents with a repetitive response.
(12) Channel activation persists through the process of platelet isolation and washing and is manifested in higher measured values of [Ca2+]cyt and [Ca2+]dt in the "resting state."
(13) At 100 microM-ACh the apparent open time became shorter probably due to channel blockade by ACh molecules.
(14) The effects of low doses of dihydropyridine (DHP) calcium channel antagonists nimodipine, nifedipine, (-)-R-202-791, and amlodipine, the DHP calcium channel agonist BAY K 8644 were investigated on clonic convulsions to pentylenetetrazole (PTZ) in mice.
(15) The following model is suggested: exogenous ATP interacts with a membrane receptor in the presence of Ca2+, a cascade of events occurs which mobilizes intracellular calcium, thereby increasing the cytosolic free Ca2+ concentration which consequently opens the calcium-activated K+ channels, which then leads to a change in membrane potential.
(16) SDS-PAGE analysis of the immunoprecipitates under reducing conditions revealed that the cardiac channel is mainly composed of two large polypeptides of 190 and 150 kDa, and five smaller polypeptides of 60, 55, 35, 30, and 25 kDa.
(17) In the presence of high external Cl, a component of outward current that was inhibited by the anion channel blocker diphenylamine-2-carboxylate (DPC) appeared in 70% of the cells.
(18) In vitro studies in cardiac Purkinje fibers suggested that reversal of amitriptyline-induced cardiac membrane effects by sodium bicarbonate may be attributed not only to alkalinization but also to increased in extracellular sodium concentration, diminishing the local anesthetic action of amitriptyline and resulting in less sodium channel block.
(19) The Ca2+ channel current recorded under identical conditions in rat dorsal root ganglion neurones was less sensitive to blockade by PCP (IC50, 90 microM).
(20) In voltage-clamp experiments the ion current flowing through the channels was homogeneous indicating a defined conformation and a uniform size.
Clough
Definition:
(n.) A cleft in a hill; a ravine; a narrow valley.
(n.) A sluice used in returning water to a channel after depositing its sediment on the flooded land.
(n.) An allowance in weighing. See Cloff.
Example Sentences:
(1) They say the footage shows Clough being pushed by police officers and struck on the head with a baton before he was pushed backwards to the ground and arrested.
(2) Later in the evening ITV1's documentary Clough pulled in 2.1 million viewers and a 10% share between 10.35pm and 11.50pm.
(3) The heavily-trailed programme was timed to coincide with the forthcoming Peter Morgan feature film The Damned United and featured exclusive interviews with family and friends of the late Brian Clough, which countered the portrayal of the outspoken football manager in the movie.
(4) Bert Clough Newbury, Berkshire • The first strike in recorded history occurred in ancient Egypt in the 12th century BC, when workers did not receive their rations.
(5) Alan Clough said he was relieved with the outcome of the court case, but had mixed feelings as he "would have liked to prove my innocence in court".
(6) After swatting aside Leeds 3-0 in the first round with goals from Franz Carr, Stuart Pearce and Garry Parker, they beat Aston Villa on penalties in the quarter-final after a 0-0 draw, surprise package Tranmere on penalties in the semi-final after a thrilling 2-2 draw with goals from Carr and Neil Webb, and Sheffield Wednesday, yes on penalties with Webb scoring the decisive spot-kick, after a goalless draw in the final - all this despite the absence of their manager, Brian Clough.
(7) And this yearning was exemplified by the men whose success came to tower over their respective cities: Shankly at Liverpool, Clough at Derby, Revie at Leeds.
(8) We have had one or two discussions, we are awaiting a decision and the owners will make that in good time,” Clough said at his pre-match press conference previewing his side’s League One trip to Bradford on Saturday.
(9) "It almost certainly was, though, at least in part a slight against Hodge, with whom Clough had a protracted battle over a new contract throughout the latter part of the season.
(10) The television presenter Charlie Webster has resigned as a patron of Sheffield United, saying: “I don’t believe a convicted rapist should go back to a club that I am patron of and should go back into the community to represent the community.” Nigel Clough said he was consulted over the Evans decision.
(11) The Sheffield United manager Nigel Clough has insisted that allowing the convicted rapist Ched Evans back to train with the club was not a precursor to offering him a deal.
(12) "Perhaps Forest's manager was relaxing his team before the fourth-round visit to Newcastle on February 11," reasoned Russell Thomas in the Guardian's match report but according to Jonathan Wilson's biography of Clough – Nobody Ever Says Thank You – there was more to the decision than that.
(13) Nigel Clough, the club’s manager, said this week it was for the owners – the millionaire businessman Kevin McCabe and Saudi prince Abdullah bin Mosaad bin Abdulaziz Al Saud – to make the call.
(14) Bert Clough The common practice among FTSE 100 companies of paying CEOs around 140 times the amount paid to the average worker in the company has to be a huge hindrance to improving productivity, especially when workers are denied a share of the profits their efforts bring to the firms.
(15) Clough, though, said the club are yet to decide what to do.
(16) The names Matt Busby, Bob Paisley, Alex Ferguson and Brian Clough were put to the Italian in the context that he may soon be joining their illustrious company, but there has never been a European Cup-winning interim first-team coach.
(17) During a discussion about the possible transfer of the Nottingham Forest striker Teddy Sheringham, Sugar said in court that Venables had informed him that Forest's legendary manager Brian Clough "likes a bung".
(18) Penny and John Clough, parents of murdered Jane: 'The system is very biased towards the defendant.'
(19) Ferguson apart, one can think of only two – Herbert Chapman and Brian Clough – who have achieved more with separate clubs.
(20) Batons are drawn and Clough is punched by an officer in riot gear who is lashing out at demonstrators.