(n.) The hollow bed where a stream of water runs or may run.
(n.) The deeper part of a river, harbor, strait, etc., where the main current flows, or which affords the best and safest passage for vessels.
(n.) A strait, or narrow sea, between two portions of lands; as, the British Channel.
(n.) That through which anything passes; means of passing, conveying, or transmitting; as, the news was conveyed to us by different channels.
(n.) A gutter; a groove, as in a fluted column.
(n.) Flat ledges of heavy plank bolted edgewise to the outside of a vessel, to increase the spread of the shrouds and carry them clear of the bulwarks.
(v. t.) To form a channel in; to cut or wear a channel or channels in; to groove.
(v. t.) To course through or over, as in a channel.
Example Sentences:
(1) These channels may, at least in some cases, be responsible for the generation of pacemaker depolarizations, thereby regulating firing behaviour.
(2) The influence of the various concepts for the induction of lateral structure formation in lipid membranes on integral functional units like ionophores is demonstrated by analysing the single channel current fluctuations of gramicidin in bimolecular lipid membranes.
(3) RNAs encoding a wild-type (RBK1) and a mutant (RBK1(Y379V,V381T); RBK1*) subunit of voltage-dependent potassium channels were injected into Xenopus oocytes.
(4) The dramas are part of the BBC2 controller Janice Hadlow's plans for her "unashamedly intelligent" channel over the coming months.
(5) This was unlike the action of the calcium channel blocker, cadmium, which reduced the calcium action potential and the a.h.p.
(6) Circuitry has been developed to feed the output of an ear densitogram pickup into one channel of a two-channel Holter monitor.
(7) It is concluded the decrease in cellular volume associated with substitution of serosal gluconate for Cl results in a loss of highly specific Ba2+-sensitive K+ conductance channels from the basolateral plasma membrane.
(8) Stimulation of atrial H1-receptors is suggested to directly cause an increase in Ca-channel conductance independent of intracellular cAMP content.
(9) Similarly, 50 microM D-600, a Ca+2 channel antagonist, significantly (P less than 0.01) reduced basal and 5-HETE-induced PRL release.
(10) The purpose of the present study was to analyze the effects of cromakalim (BRL 34915), a potent drug from a new class of drugs characterized as "K+ channel openers", on the electrical activity of human skeletal muscle.
(11) This promotion of repetitive activity by the introduction of additional potassium channels occurred up to an "optimal" value beyond which a further increase in paranodal potassium permeability narrowed the range of currents with a repetitive response.
(12) Channel activation persists through the process of platelet isolation and washing and is manifested in higher measured values of [Ca2+]cyt and [Ca2+]dt in the "resting state."
(13) At 100 microM-ACh the apparent open time became shorter probably due to channel blockade by ACh molecules.
(14) The effects of low doses of dihydropyridine (DHP) calcium channel antagonists nimodipine, nifedipine, (-)-R-202-791, and amlodipine, the DHP calcium channel agonist BAY K 8644 were investigated on clonic convulsions to pentylenetetrazole (PTZ) in mice.
(15) The following model is suggested: exogenous ATP interacts with a membrane receptor in the presence of Ca2+, a cascade of events occurs which mobilizes intracellular calcium, thereby increasing the cytosolic free Ca2+ concentration which consequently opens the calcium-activated K+ channels, which then leads to a change in membrane potential.
(16) SDS-PAGE analysis of the immunoprecipitates under reducing conditions revealed that the cardiac channel is mainly composed of two large polypeptides of 190 and 150 kDa, and five smaller polypeptides of 60, 55, 35, 30, and 25 kDa.
(17) In the presence of high external Cl, a component of outward current that was inhibited by the anion channel blocker diphenylamine-2-carboxylate (DPC) appeared in 70% of the cells.
(18) In vitro studies in cardiac Purkinje fibers suggested that reversal of amitriptyline-induced cardiac membrane effects by sodium bicarbonate may be attributed not only to alkalinization but also to increased in extracellular sodium concentration, diminishing the local anesthetic action of amitriptyline and resulting in less sodium channel block.
(19) The Ca2+ channel current recorded under identical conditions in rat dorsal root ganglion neurones was less sensitive to blockade by PCP (IC50, 90 microM).
(20) In voltage-clamp experiments the ion current flowing through the channels was homogeneous indicating a defined conformation and a uniform size.
Historic
Definition:
(a.) Alt. of Historical
Example Sentences:
(1) Single-case experimental designs are presented and discussed from several points of view: Historical antecedents, assessment of the dependent variable, internal and external validity and pre-experimental vs experimental single-case designs.
(2) Historical analysis shows that institutions and special education services spring from common, although not identical, societal and philosophical forces.
(3) David Cameron last night hit out at his fellow world leaders after the G8 dropped the promise to meet the historic aid commitments made at Gleneagles in 2005 from this year's summit communique.
(4) At its vanguard is the historic quarter of Barriera di Milano, which is being transformed by an influx of artists and galleries.
(5) On Friday, a spokesperson for China’s foreign ministry appeared to confirm those fears, telling reporters that the joint declaration, a deal negotiated by London and Beijing guaranteeing Hong Kong’s way of life for 50 years, “was a historical document that no longer had any practical significance”.
(6) When compared with a matched group of historical control subjects treated with RT alone, chemotherapy induced a higher rate of neurologic response and led to a longer survival time.
(7) This paper provides power formulae for historically controlled studies with survival time endpoints, and considers two designs.
(8) Historically, councils and housing associations have tended to build three-bedroom houses, because that has always been seen as a sensible size for a family home.
(9) This month, Ucas will bring out an interactive map of Gaza , with live updates, highlighting sports events and restaurants, as well as areas of historical interest.
(10) Historical reality suggests the concept of socially necessary risk determined through the dialectic process in democracy.
(11) The ANC has the historical responsibility to lead our nation and help build a united non-racial society."
(12) But we need politicians to break out of historical routines.
(13) The arrival on Monday was another first for the two countries since Barack Obama and Cuban President Raúl Castro announced a historic rapprochement in December 2014, and comes weeks after Obama’s visit to the Caribbean island.
(14) And that is why we have taken bold action at home – by making historic investments in renewable energy; by putting our people to work increasing efficiency in our homes and buildings; and by pursuing comprehensive legislation to transform to a clean energy economy.
(15) Sometimes it can seem as if the history of the City is the history of its crises and disasters, from the banking crisis of 1825 (which saw undercapitalised banks collapse – perhaps the closest historic parallel to the contemporary credit crunch), through the Spanish panic of 1835, the railway bust of 1837, the crash of Overend Gurney, the Kaffir boom, the Westralian boom, the Marconi scandal, and so on and on – a theme with endless variations.
(16) Historically, research into the regulation of gene expression in primate lentiviruses has focused on human immunodeficiency virus type 1 (HIV-1), the primary cause of acquired immunodeficiency syndrome (AIDS) in humans.
(17) The art Kennard produced formed the basis of his career, as he recounted later: “I studied as a painter, but after the events of 1968 I began to look for a form of expression that could bring art and politics together to a wider audience … I found that photography wasn’t as burdened with similar art historical associations.” The result was his STOP montage series.
(18) Long-standing providers preferred a categorical approach in order to maintain a diverse political coalition for an historically invisible service.
(19) Historically, what made SNL’s campaign coverage so necessary was its ability to highlight the subtle absurdities of the election and exaggerate the ridiculous.
(20) World leaders must reach a historic agreement to fight climate change and poverty at coming talks in Paris, facing the stark choice to either “improve or destroy the environment”, Pope Francis said in Africa on Thursday.