(n.) The hollow bed where a stream of water runs or may run.
(n.) The deeper part of a river, harbor, strait, etc., where the main current flows, or which affords the best and safest passage for vessels.
(n.) A strait, or narrow sea, between two portions of lands; as, the British Channel.
(n.) That through which anything passes; means of passing, conveying, or transmitting; as, the news was conveyed to us by different channels.
(n.) A gutter; a groove, as in a fluted column.
(n.) Flat ledges of heavy plank bolted edgewise to the outside of a vessel, to increase the spread of the shrouds and carry them clear of the bulwarks.
(v. t.) To form a channel in; to cut or wear a channel or channels in; to groove.
(v. t.) To course through or over, as in a channel.
Example Sentences:
(1) These channels may, at least in some cases, be responsible for the generation of pacemaker depolarizations, thereby regulating firing behaviour.
(2) The influence of the various concepts for the induction of lateral structure formation in lipid membranes on integral functional units like ionophores is demonstrated by analysing the single channel current fluctuations of gramicidin in bimolecular lipid membranes.
(3) RNAs encoding a wild-type (RBK1) and a mutant (RBK1(Y379V,V381T); RBK1*) subunit of voltage-dependent potassium channels were injected into Xenopus oocytes.
(4) The dramas are part of the BBC2 controller Janice Hadlow's plans for her "unashamedly intelligent" channel over the coming months.
(5) This was unlike the action of the calcium channel blocker, cadmium, which reduced the calcium action potential and the a.h.p.
(6) Circuitry has been developed to feed the output of an ear densitogram pickup into one channel of a two-channel Holter monitor.
(7) It is concluded the decrease in cellular volume associated with substitution of serosal gluconate for Cl results in a loss of highly specific Ba2+-sensitive K+ conductance channels from the basolateral plasma membrane.
(8) Stimulation of atrial H1-receptors is suggested to directly cause an increase in Ca-channel conductance independent of intracellular cAMP content.
(9) Similarly, 50 microM D-600, a Ca+2 channel antagonist, significantly (P less than 0.01) reduced basal and 5-HETE-induced PRL release.
(10) The purpose of the present study was to analyze the effects of cromakalim (BRL 34915), a potent drug from a new class of drugs characterized as "K+ channel openers", on the electrical activity of human skeletal muscle.
(11) This promotion of repetitive activity by the introduction of additional potassium channels occurred up to an "optimal" value beyond which a further increase in paranodal potassium permeability narrowed the range of currents with a repetitive response.
(12) Channel activation persists through the process of platelet isolation and washing and is manifested in higher measured values of [Ca2+]cyt and [Ca2+]dt in the "resting state."
(13) At 100 microM-ACh the apparent open time became shorter probably due to channel blockade by ACh molecules.
(14) The effects of low doses of dihydropyridine (DHP) calcium channel antagonists nimodipine, nifedipine, (-)-R-202-791, and amlodipine, the DHP calcium channel agonist BAY K 8644 were investigated on clonic convulsions to pentylenetetrazole (PTZ) in mice.
(15) The following model is suggested: exogenous ATP interacts with a membrane receptor in the presence of Ca2+, a cascade of events occurs which mobilizes intracellular calcium, thereby increasing the cytosolic free Ca2+ concentration which consequently opens the calcium-activated K+ channels, which then leads to a change in membrane potential.
(16) SDS-PAGE analysis of the immunoprecipitates under reducing conditions revealed that the cardiac channel is mainly composed of two large polypeptides of 190 and 150 kDa, and five smaller polypeptides of 60, 55, 35, 30, and 25 kDa.
(17) In the presence of high external Cl, a component of outward current that was inhibited by the anion channel blocker diphenylamine-2-carboxylate (DPC) appeared in 70% of the cells.
(18) In vitro studies in cardiac Purkinje fibers suggested that reversal of amitriptyline-induced cardiac membrane effects by sodium bicarbonate may be attributed not only to alkalinization but also to increased in extracellular sodium concentration, diminishing the local anesthetic action of amitriptyline and resulting in less sodium channel block.
(19) The Ca2+ channel current recorded under identical conditions in rat dorsal root ganglion neurones was less sensitive to blockade by PCP (IC50, 90 microM).
(20) In voltage-clamp experiments the ion current flowing through the channels was homogeneous indicating a defined conformation and a uniform size.
Moral
Definition:
(a.) Relating to duty or obligation; pertaining to those intentions and actions of which right and wrong, virtue and vice, are predicated, or to the rules by which such intentions and actions ought to be directed; relating to the practice, manners, or conduct of men as social beings in relation to each other, as respects right and wrong, so far as they are properly subject to rules.
(a.) Conformed to accepted rules of right; acting in conformity with such rules; virtuous; just; as, a moral man. Used sometimes in distinction from religious; as, a moral rather than a religious life.
(a.) Capable of right and wrong action or of being governed by a sense of right; subject to the law of duty.
(a.) Acting upon or through one's moral nature or sense of right, or suited to act in such a manner; as, a moral arguments; moral considerations. Sometimes opposed to material and physical; as, moral pressure or support.
(a.) Supported by reason or probability; practically sufficient; -- opposed to legal or demonstrable; as, a moral evidence; a moral certainty.
(a.) Serving to teach or convey a moral; as, a moral lesson; moral tales.
(n.) The doctrine or practice of the duties of life; manner of living as regards right and wrong; conduct; behavior; -- usually in the plural.
(n.) The inner meaning or significance of a fable, a narrative, an occurrence, an experience, etc.; the practical lesson which anything is designed or fitted to teach; the doctrine meant to be inculcated by a fiction; a maxim.
(n.) A morality play. See Morality, 5.
(v. i.) To moralize.
Example Sentences:
(1) Along the spectrum of loyalties lie multiple loyalties and ambiguous loyalties, and the latter, if unresolved, create moral ambiguities.
(2) With respect to family environment, a history of sexual abuse was associated with perceptions that families of origin had less cohesion, more conflict, less emphasis on moral-religious matters, less emphasis on achievement, and less of an orientation towards intellectual, cultural, and recreational pursuits.
(3) The matter is now in the hands of the Guernsey police and the law officers.” One resident who is a constant target of the paper and has complained to police, Rosie Guille, said the allegations had a “huge impact on morale” on the island.
(4) Guardian Australia reported last week that morale at the national laboratory had fallen dramatically, with one in three staff “seriously considering” leaving their jobs in the wake of the cuts.
(5) And this has opened up a loophole for businesses to be morally bankrupt, ignoring the obligations to its workforce because no legal conduct has been established.” Whatever the outcome of the pending lawsuits, it’s unlikely that just one model will work for everybody.
(6) If we’re waiting around for the Democratic version to sail through here, or the Republican version to sail through here, all those victims who are waiting for us to do something will wait for days, months, years, forever and we won’t get anything done.” Senator Bill Nelson, whose home state of Florida is still reeling from the Orlando shooting, said he felt morally obligated to return to his constituents with results.
(7) In his notorious 1835 Minute on Education , Lord Macaulay articulated the classic reason for teaching English, but only to a small minority of Indians: “We must do our best to form a class who may be interpreters between us and the millions whom we govern; a class of persons, Indians in blood and colour, but English in taste, in opinions, in morals and in intellect.” The language was taught to a few to serve as intermediaries between the rulers and the ruled.
(8) This paper discusses the relationship between the psychoanalytic concept of character and the moral considerations of 'character'.
(9) "This will obviously be a sensitive topic for the US administration, but partners in the transatlantic alliance must be clear on common rules of engagement in times of conflict if we are to retain any moral standing in the world," Verhofstadt said.
(10) This continuing influence of Nazi medicine raises profound questions for the epistemology and morality of medicine.
(11) But with the advantages and attractions that Scotland already has, and, more importantly, taking into account the morale boost, the sheer energisation of a whole people that would come about because we would finally have our destiny at least largely back in our own hands again – I think we could do it.
(12) But none of those calling on Obama to act carries the moral authority of Gore, who has devoted his post-political career to building a climate movement.
(13) Fleeting though it may have been (he jetted off to New York this morning and is due in Toronto on Saturday), there was a poignant reason for his appearance: he was here to play a tribute set to Frankie Knuckles, the Godfather of house and one of Morales's closest friends, who died suddenly in March.
(14) The government also faced considerable international political pressure, with the United Nations' special rapporteur on torture, Juan Méndez, calling publicly on the government to "provide full redress to the victims, including fair and adequate compensation", and writing privately to David Cameron, along with two former special rapporteurs, to warn that the government's position was undermining its moral authority across the world.
(15) Father Vincent Twomey said that given the damage done by Smyth and the repercussions of his actions, "one way or another the cardinal has unfortunately lost his moral credibility".
(16) This is a moral swamp, but it's one the Salvation Army claims to be stepping into out of charity .
(17) In what appeared to be pointed criticism of increasingly firm rhetoric from Cameron on multinational tax engineering, Carr insisted tax avoidance "cannot be about morality – there are no absolutes".
(18) For an industry built on selling ersatz rebellion to teenagers, finding the moral high ground was always going to be tricky.
(19) A vigorous progressive physical and occupational therapy program producing tangible results does more for the patient's morale than any verbal encouragement could possibly do.
(20) We have a moral duty to conserve them and to educate people about their habitat, health and the threats they face."