(n.) The hollow bed where a stream of water runs or may run.
(n.) The deeper part of a river, harbor, strait, etc., where the main current flows, or which affords the best and safest passage for vessels.
(n.) A strait, or narrow sea, between two portions of lands; as, the British Channel.
(n.) That through which anything passes; means of passing, conveying, or transmitting; as, the news was conveyed to us by different channels.
(n.) A gutter; a groove, as in a fluted column.
(n.) Flat ledges of heavy plank bolted edgewise to the outside of a vessel, to increase the spread of the shrouds and carry them clear of the bulwarks.
(v. t.) To form a channel in; to cut or wear a channel or channels in; to groove.
(v. t.) To course through or over, as in a channel.
Example Sentences:
(1) These channels may, at least in some cases, be responsible for the generation of pacemaker depolarizations, thereby regulating firing behaviour.
(2) The influence of the various concepts for the induction of lateral structure formation in lipid membranes on integral functional units like ionophores is demonstrated by analysing the single channel current fluctuations of gramicidin in bimolecular lipid membranes.
(3) RNAs encoding a wild-type (RBK1) and a mutant (RBK1(Y379V,V381T); RBK1*) subunit of voltage-dependent potassium channels were injected into Xenopus oocytes.
(4) The dramas are part of the BBC2 controller Janice Hadlow's plans for her "unashamedly intelligent" channel over the coming months.
(5) This was unlike the action of the calcium channel blocker, cadmium, which reduced the calcium action potential and the a.h.p.
(6) Circuitry has been developed to feed the output of an ear densitogram pickup into one channel of a two-channel Holter monitor.
(7) It is concluded the decrease in cellular volume associated with substitution of serosal gluconate for Cl results in a loss of highly specific Ba2+-sensitive K+ conductance channels from the basolateral plasma membrane.
(8) Stimulation of atrial H1-receptors is suggested to directly cause an increase in Ca-channel conductance independent of intracellular cAMP content.
(9) Similarly, 50 microM D-600, a Ca+2 channel antagonist, significantly (P less than 0.01) reduced basal and 5-HETE-induced PRL release.
(10) The purpose of the present study was to analyze the effects of cromakalim (BRL 34915), a potent drug from a new class of drugs characterized as "K+ channel openers", on the electrical activity of human skeletal muscle.
(11) This promotion of repetitive activity by the introduction of additional potassium channels occurred up to an "optimal" value beyond which a further increase in paranodal potassium permeability narrowed the range of currents with a repetitive response.
(12) Channel activation persists through the process of platelet isolation and washing and is manifested in higher measured values of [Ca2+]cyt and [Ca2+]dt in the "resting state."
(13) At 100 microM-ACh the apparent open time became shorter probably due to channel blockade by ACh molecules.
(14) The effects of low doses of dihydropyridine (DHP) calcium channel antagonists nimodipine, nifedipine, (-)-R-202-791, and amlodipine, the DHP calcium channel agonist BAY K 8644 were investigated on clonic convulsions to pentylenetetrazole (PTZ) in mice.
(15) The following model is suggested: exogenous ATP interacts with a membrane receptor in the presence of Ca2+, a cascade of events occurs which mobilizes intracellular calcium, thereby increasing the cytosolic free Ca2+ concentration which consequently opens the calcium-activated K+ channels, which then leads to a change in membrane potential.
(16) SDS-PAGE analysis of the immunoprecipitates under reducing conditions revealed that the cardiac channel is mainly composed of two large polypeptides of 190 and 150 kDa, and five smaller polypeptides of 60, 55, 35, 30, and 25 kDa.
(17) In the presence of high external Cl, a component of outward current that was inhibited by the anion channel blocker diphenylamine-2-carboxylate (DPC) appeared in 70% of the cells.
(18) In vitro studies in cardiac Purkinje fibers suggested that reversal of amitriptyline-induced cardiac membrane effects by sodium bicarbonate may be attributed not only to alkalinization but also to increased in extracellular sodium concentration, diminishing the local anesthetic action of amitriptyline and resulting in less sodium channel block.
(19) The Ca2+ channel current recorded under identical conditions in rat dorsal root ganglion neurones was less sensitive to blockade by PCP (IC50, 90 microM).
(20) In voltage-clamp experiments the ion current flowing through the channels was homogeneous indicating a defined conformation and a uniform size.
Narrow
Definition:
(superl.) Of little breadth; not wide or broad; having little distance from side to side; as, a narrow board; a narrow street; a narrow hem.
(superl.) Of little extent; very limited; circumscribed.
(superl.) Having but a little margin; having barely sufficient space, time, or number, etc.; close; near; -- with special reference to some peril or misfortune; as, a narrow shot; a narrow escape; a narrow majority.
(superl.) Limited as to means; straitened; pinching; as, narrow circumstances.
(superl.) Contracted; of limited scope; illiberal; bigoted; as, a narrow mind; narrow views.
(superl.) Scrutinizing in detail; close; accurate; exact.
(superl.) Formed (as a vowel) by a close position of some part of the tongue in relation to the palate; or (according to Bell) by a tense condition of the pharynx; -- distinguished from wide; as e (eve) and / (f/d), etc., from i (ill) and / (f/t), etc. See Guide to Pronunciation, / 13.
(n.) A narrow passage; esp., a contracted part of a stream, lake, or sea; a strait connecting two bodies of water; -- usually in the plural; as, The Narrows of New York harbor.
(v. t.) To lessen the breadth of; to contract; to draw into a smaller compass; to reduce the width or extent of.
(v. t.) To contract the reach or sphere of; to make less liberal or more selfish; to limit; to confine; to restrict; as, to narrow one's views or knowledge; to narrow a question in discussion.
(v. t.) To contract the size of, as a stocking, by taking two stitches into one.
(v. i.) To become less broad; to contract; to become narrower; as, the sea narrows into a strait.
(v. i.) Not to step out enough to the one hand or the other; as, a horse narrows.
(v. i.) To contract the size of a stocking or other knit article, by taking two stitches into one.
Example Sentences:
(1) The PSB dioxygenase system displayed a narrow substrate range: none of 18 sulphonated or non-sulphonated analogues of PSB showed significant substrate-dependent O2 uptake.
(2) Comparison of developmental series of D. merriami and T. bottae revealed that the decline of the artery in the latter species is preceded by a greater degree of arterial coarctation, or narrowing, as it passes though the developing stapes.
(3) This promotion of repetitive activity by the introduction of additional potassium channels occurred up to an "optimal" value beyond which a further increase in paranodal potassium permeability narrowed the range of currents with a repetitive response.
(4) In all immunized rabbits the antisera obtained with the 7 alpha-derivative had a higher affinity and a narrower specificity than the antiserum obtained with the 7 beta-derivative.
(5) That is, he believes, to look at massively difficult, interlocking problems through too narrow a lens.
(6) Photograph: AP Reasons for wavering • State relies on coal-fired electricity • Poor prospects for wind power • Conservative Democrat • Represents conservative district in conservative state and was elected on narrow margins Campaign support from fossil fuel interests in 2008 • $93,743 G K Butterfield (North Carolina) GK Butterfield, North Carolina.
(7) Their narrowed processes pass at a common site through the muscle layer and above this layer again slightly widen and project above the neighbouring tegument.
(8) These patients did not have narrow anterior chamber angles preoperatively, and several were aphakix with surgical iris colobomas.
(9) The linewidths of the methionine Cepsilon resonances are narrowed by increasing temperature according to an Arrhenius energy of activation of nearly 3 kcal.
(10) The detergent lauryl maltoside abolishes respiratory control and proton ejection by cytochrome c oxidase-containing proteoliposomes over a narrow concentration range.
(11) Per-rotational nystagmus was recorded in rabbits with unilaterally narrowed vertebral arteries or following unilateral cervical sympathectomies.
(12) However, the narrow range of the ED50 suggests relatively little variation in the response of the different isolates in vivo and similarly small variation was also noted in some of the tests in vitro.
(13) Eight patients had glaucoma only in one eye; three narrow-angle glaucoma, three primary open-angle glaucoma and two secondary glaucoma.
(14) In the fifth case the vein was too narrow to allow catheterization.
(15) It was found that within the dorsal part of the well known pressor area there is a narrow strip, 2.5 mm lateral from the mid line, starting ventral to the inferior colliculus and ending in the medulla close to the floor of the IV ventricle, from which vasodilatation in skeletal muscles is selectively obtained.
(16) Each border was within a region of 11 nucleotides and gave rise to a narrow size range (1248-1261 nucleotides) for the population of 22 subgenomic DNAs.
(17) These factors include narrowing of septal arteries and the artery to the atrioventricular node, preservation of fetal anatomy with dispersion in the atrioventricular node and His bundle, fibrosis of the sinus node, clefts in the septum, multiple atrioventricular pathways and massive myocardial infarction.
(18) Time suggests that the FBI inquiry has been extended from a relatively narrow look at alleged malpractices by News Corp in America into a more general inquiry into whether the company used possibly illegal strongarm tactics to browbeat rival firms, following allegations of computer hacking made by retail advertising company Floorgraphics.
(19) These three activities, appearing within a narrow range of molecular weights, different from those of other known lymphokines, suggest the existence of a distinct class of lymphokine mediators with the common function of influencing functional properties of tumor cells.
(20) The narrow intercellular ridge is smooth, whereas the epithelial cells have small cytoplasmic knobs between the cilia.