(n.) The hollow bed where a stream of water runs or may run.
(n.) The deeper part of a river, harbor, strait, etc., where the main current flows, or which affords the best and safest passage for vessels.
(n.) A strait, or narrow sea, between two portions of lands; as, the British Channel.
(n.) That through which anything passes; means of passing, conveying, or transmitting; as, the news was conveyed to us by different channels.
(n.) A gutter; a groove, as in a fluted column.
(n.) Flat ledges of heavy plank bolted edgewise to the outside of a vessel, to increase the spread of the shrouds and carry them clear of the bulwarks.
(v. t.) To form a channel in; to cut or wear a channel or channels in; to groove.
(v. t.) To course through or over, as in a channel.
Example Sentences:
(1) These channels may, at least in some cases, be responsible for the generation of pacemaker depolarizations, thereby regulating firing behaviour.
(2) The influence of the various concepts for the induction of lateral structure formation in lipid membranes on integral functional units like ionophores is demonstrated by analysing the single channel current fluctuations of gramicidin in bimolecular lipid membranes.
(3) RNAs encoding a wild-type (RBK1) and a mutant (RBK1(Y379V,V381T); RBK1*) subunit of voltage-dependent potassium channels were injected into Xenopus oocytes.
(4) The dramas are part of the BBC2 controller Janice Hadlow's plans for her "unashamedly intelligent" channel over the coming months.
(5) This was unlike the action of the calcium channel blocker, cadmium, which reduced the calcium action potential and the a.h.p.
(6) Circuitry has been developed to feed the output of an ear densitogram pickup into one channel of a two-channel Holter monitor.
(7) It is concluded the decrease in cellular volume associated with substitution of serosal gluconate for Cl results in a loss of highly specific Ba2+-sensitive K+ conductance channels from the basolateral plasma membrane.
(8) Stimulation of atrial H1-receptors is suggested to directly cause an increase in Ca-channel conductance independent of intracellular cAMP content.
(9) Similarly, 50 microM D-600, a Ca+2 channel antagonist, significantly (P less than 0.01) reduced basal and 5-HETE-induced PRL release.
(10) The purpose of the present study was to analyze the effects of cromakalim (BRL 34915), a potent drug from a new class of drugs characterized as "K+ channel openers", on the electrical activity of human skeletal muscle.
(11) This promotion of repetitive activity by the introduction of additional potassium channels occurred up to an "optimal" value beyond which a further increase in paranodal potassium permeability narrowed the range of currents with a repetitive response.
(12) Channel activation persists through the process of platelet isolation and washing and is manifested in higher measured values of [Ca2+]cyt and [Ca2+]dt in the "resting state."
(13) At 100 microM-ACh the apparent open time became shorter probably due to channel blockade by ACh molecules.
(14) The effects of low doses of dihydropyridine (DHP) calcium channel antagonists nimodipine, nifedipine, (-)-R-202-791, and amlodipine, the DHP calcium channel agonist BAY K 8644 were investigated on clonic convulsions to pentylenetetrazole (PTZ) in mice.
(15) The following model is suggested: exogenous ATP interacts with a membrane receptor in the presence of Ca2+, a cascade of events occurs which mobilizes intracellular calcium, thereby increasing the cytosolic free Ca2+ concentration which consequently opens the calcium-activated K+ channels, which then leads to a change in membrane potential.
(16) SDS-PAGE analysis of the immunoprecipitates under reducing conditions revealed that the cardiac channel is mainly composed of two large polypeptides of 190 and 150 kDa, and five smaller polypeptides of 60, 55, 35, 30, and 25 kDa.
(17) In the presence of high external Cl, a component of outward current that was inhibited by the anion channel blocker diphenylamine-2-carboxylate (DPC) appeared in 70% of the cells.
(18) In vitro studies in cardiac Purkinje fibers suggested that reversal of amitriptyline-induced cardiac membrane effects by sodium bicarbonate may be attributed not only to alkalinization but also to increased in extracellular sodium concentration, diminishing the local anesthetic action of amitriptyline and resulting in less sodium channel block.
(19) The Ca2+ channel current recorded under identical conditions in rat dorsal root ganglion neurones was less sensitive to blockade by PCP (IC50, 90 microM).
(20) In voltage-clamp experiments the ion current flowing through the channels was homogeneous indicating a defined conformation and a uniform size.
Obsolete
Definition:
(a.) No longer in use; gone into disuse; disused; neglected; as, an obsolete word; an obsolete statute; -- applied chiefly to words, writings, or observances.
(a.) Not very distinct; obscure; rudimental; imperfectly developed; abortive.
(v. i.) To become obsolete; to go out of use.
Example Sentences:
(1) Individual tests and batteries of tests should be standardized, employ positive controls, generate results capable of quantitative analyses that may make dichotomous classification as "positive" and "negative" obsolete, be interpreted in light of mechanisms of action, and be cost-effective on a grand scale.
(2) This study suggests that pneumoencephalography may be obsolete and that the diagnosis of olivopontocerebellar degeneration may be established by abnormalities seen during computerized tomography (CT) and by abnormal responses to auditory-evoked potentials (AEPs).
(3) Genomic mapping is proceeding at such a rapid pace that any printed version of the anatomy of the human genome is immediately obsolete.
(4) Handheld computers may make bedside terminals obsolete.
(5) The ambulatory 24 hour pH test may have rendered the AP test obsolete in the assessment of GORD as the cause of NCCP.
(6) Rather than becoming obsolete by 2030, as its designers thought, the barrier will not need to be replaced until 2070, the agency said today.
(7) Will Netflix make traditional TV channels obsolete?
(8) Ratified in 1980, the document is widely seen as obsolete and part of what she hopes to change with her "democratic revolution" – a plan she says could be financed by higher corporation taxes and which works within the boundaries of a constitutional democracy.
(9) The advent of high-resolution contrast CT will probably make obsolete the use of contrast media.
(10) The time needed to review and publish an article or a book dictates that by the time it is published, any statements about current hardware will be obsolete.
(11) The term "fibrositis" for generalized tendomyopathia that can still be found in Anglo-American literature is obsolete.
(12) In all other patients the PAVS is a very valuable instrument in the surgical management of hydrocephalus because it makes shunt revisions for inadequate valve pressure obsolete in individual patients.
(13) The secondary nasal skin envelope asymmetries were studied after unilateral cleft lip repair using the original (obsolete) rotation-advancement (Millard I) and the triangular flap techniques (Bardach's modification).
(14) Gradually these young men and their would-be families become functionally obsolete in society.
(15) Finally, it is imperative that the obsolete Nigerian Children and Young Person's Law be updated.
(16) I do not accept that the great achievements of the left – unionisation, social security – are obsolete.
(17) Some daggers have already been drawn – François Rebsamen , said the revelations showed the entire idea of "première dame", was obsolete, adding that scrapping of the office of the first lady would be progress for democracy.
(18) Here we describe a new method of synthesizing an immunogenic peptide antigen, referred to as multiple antigenic peptide (MAP), which may render the need for a carrier protein obsolete.
(19) The TRH stimulation test is virtually obsolete for the diagnosis of thyrotoxicosis but remains of much interest in the investigation of psychiatric syndromes.
(20) It should be kept in mind that recent changes in OC formulations and use patterns render epidemiologic data now available obsolete.