(n.) The hollow bed where a stream of water runs or may run.
(n.) The deeper part of a river, harbor, strait, etc., where the main current flows, or which affords the best and safest passage for vessels.
(n.) A strait, or narrow sea, between two portions of lands; as, the British Channel.
(n.) That through which anything passes; means of passing, conveying, or transmitting; as, the news was conveyed to us by different channels.
(n.) A gutter; a groove, as in a fluted column.
(n.) Flat ledges of heavy plank bolted edgewise to the outside of a vessel, to increase the spread of the shrouds and carry them clear of the bulwarks.
(v. t.) To form a channel in; to cut or wear a channel or channels in; to groove.
(v. t.) To course through or over, as in a channel.
Example Sentences:
(1) These channels may, at least in some cases, be responsible for the generation of pacemaker depolarizations, thereby regulating firing behaviour.
(2) The influence of the various concepts for the induction of lateral structure formation in lipid membranes on integral functional units like ionophores is demonstrated by analysing the single channel current fluctuations of gramicidin in bimolecular lipid membranes.
(3) RNAs encoding a wild-type (RBK1) and a mutant (RBK1(Y379V,V381T); RBK1*) subunit of voltage-dependent potassium channels were injected into Xenopus oocytes.
(4) The dramas are part of the BBC2 controller Janice Hadlow's plans for her "unashamedly intelligent" channel over the coming months.
(5) This was unlike the action of the calcium channel blocker, cadmium, which reduced the calcium action potential and the a.h.p.
(6) Circuitry has been developed to feed the output of an ear densitogram pickup into one channel of a two-channel Holter monitor.
(7) It is concluded the decrease in cellular volume associated with substitution of serosal gluconate for Cl results in a loss of highly specific Ba2+-sensitive K+ conductance channels from the basolateral plasma membrane.
(8) Stimulation of atrial H1-receptors is suggested to directly cause an increase in Ca-channel conductance independent of intracellular cAMP content.
(9) Similarly, 50 microM D-600, a Ca+2 channel antagonist, significantly (P less than 0.01) reduced basal and 5-HETE-induced PRL release.
(10) The purpose of the present study was to analyze the effects of cromakalim (BRL 34915), a potent drug from a new class of drugs characterized as "K+ channel openers", on the electrical activity of human skeletal muscle.
(11) This promotion of repetitive activity by the introduction of additional potassium channels occurred up to an "optimal" value beyond which a further increase in paranodal potassium permeability narrowed the range of currents with a repetitive response.
(12) Channel activation persists through the process of platelet isolation and washing and is manifested in higher measured values of [Ca2+]cyt and [Ca2+]dt in the "resting state."
(13) At 100 microM-ACh the apparent open time became shorter probably due to channel blockade by ACh molecules.
(14) The effects of low doses of dihydropyridine (DHP) calcium channel antagonists nimodipine, nifedipine, (-)-R-202-791, and amlodipine, the DHP calcium channel agonist BAY K 8644 were investigated on clonic convulsions to pentylenetetrazole (PTZ) in mice.
(15) The following model is suggested: exogenous ATP interacts with a membrane receptor in the presence of Ca2+, a cascade of events occurs which mobilizes intracellular calcium, thereby increasing the cytosolic free Ca2+ concentration which consequently opens the calcium-activated K+ channels, which then leads to a change in membrane potential.
(16) SDS-PAGE analysis of the immunoprecipitates under reducing conditions revealed that the cardiac channel is mainly composed of two large polypeptides of 190 and 150 kDa, and five smaller polypeptides of 60, 55, 35, 30, and 25 kDa.
(17) In the presence of high external Cl, a component of outward current that was inhibited by the anion channel blocker diphenylamine-2-carboxylate (DPC) appeared in 70% of the cells.
(18) In vitro studies in cardiac Purkinje fibers suggested that reversal of amitriptyline-induced cardiac membrane effects by sodium bicarbonate may be attributed not only to alkalinization but also to increased in extracellular sodium concentration, diminishing the local anesthetic action of amitriptyline and resulting in less sodium channel block.
(19) The Ca2+ channel current recorded under identical conditions in rat dorsal root ganglion neurones was less sensitive to blockade by PCP (IC50, 90 microM).
(20) In voltage-clamp experiments the ion current flowing through the channels was homogeneous indicating a defined conformation and a uniform size.
Pursue
Definition:
(v. t.) To follow with a view to overtake; to follow eagerly, or with haste; to chase; as, to pursue a hare.
(v. t.) To seek; to use or adopt measures to obtain; as, to pursue a remedy at law.
(v. t.) To proceed along, with a view to some and or object; to follow; to go in; as, Captain Cook pursued a new route; the administration pursued a wise course.
(v. t.) To prosecute; to be engaged in; to continue.
(v. t.) To follow as an example; to imitate.
(v. t.) To follow with enmity; to persecute; to call to account.
(v. i.) To go in pursuit; to follow.
(v. i.) To go on; to proceed, especially in argument or discourse; to continue.
(v. i.) To follow a matter judicially, as a complaining party; to act as a prosecutor.
Example Sentences:
(1) The idea that 80% of an engineer's time is spent on the day job and 20% pursuing a personal project is a mathematician's solution to innovation, Brin says.
(2) We are pursuing legal action because there are still so many unanswered questions about the viability of Shenhua’s proposed koala plan and it seems at this point the plan does not guarantee the survival of the estimated 262 koalas currently living where Shenhua wants to put its mine,” said Ranclaud.
(3) We have now started a prospective follow-up study in order to pursue the development of (a) p-ERG amplitudes and (b) funduscopic changes and visual acuity in these patients.
(4) Principal conclusions are: 1) rapid change to predominantly heterosexual HIV transmission can occur in North America, with serious societal impact; 2) gender-specific clinical features can lead to earlier diagnosis of HIV infection in women; 3) HIV infection in women does not pursue an inherently more rapid course than that observed in men.
(5) These results suggest that ED2+ macrophages, TRPM-3+ macrophages, and Ia+ dendritic cells are distinct cell lines that pursue independent developmental process in spleen ontogeny.
(6) In conclusion, 1) etiology of urinary tract stone in all recurrent stone formers and in all patients with multiple stones must be pursued, and 2) all stones either removed or passed must be subjected to infrared spectrometry.
(7) And that is why we have taken bold action at home – by making historic investments in renewable energy; by putting our people to work increasing efficiency in our homes and buildings; and by pursuing comprehensive legislation to transform to a clean energy economy.
(8) He said he will pursue new measures, including demolishing the homes of instigators.
(9) Pfizer kept up its efforts to get AstraZeneca to the negotiating table over its £63bn approach as it reported revenue well below Wall Street expectations, underscoring its interest in pursuing its UK rival to promote new business growth.
(10) Bostock, who is long thought to have had a tense relationship with chief executive Marc Bolland , is departing by "mutual consent to pursue other interests" on 1 October, when she will also leave the M&S board.
(11) We are effectively in funding limbo Professor Barney Glover, Universities Australia chair Glover was also set to emphasise the need for affordability because “cost must not deter any capable student from pursuing a university education”.
(12) Many cases before the commissioner remain unresolved, although those who wish to pursue matters to the tribunal as part of the transitional arrangements will not have to pay an additional fee to appeal to the tribunal.
(13) "And if you're pursuing music as the equivalent of your nine-to-five, and you'd quite like to be doing that for years to come, it's in your interest not to rock the boat."
(14) Residents of Cardiff , Cumbria and Plymouth are either dallying with the idea or actively pursuing it.
(15) According to his blog, he's been acting on the advice of a friend and pursuing a course of "silence, exile and cunning", but I'm not sure a couple of years of not giving interviews to Heat qualifies.
(16) However, further studies involving more patients are required to pursue this hypothesis.
(17) That is the strategy I’m pursuing in Nehalem, Oregon , where I recently ran for mayor.
(18) Other findings showed highly satisfactory to above average performance of graduates whether based on residency supervisors' evaluations or self-evaluations and higher ratings for the graduates who selected surgery residency programs than for those pursuing other disciplines.
(19) A hypothetical scheme is presented that pursues the processes involved in invasion from the biochemical events generated by attachment of the parasite, to the steric rearrangement of red cell membrane proteins, which culminates in invasion.
(20) While Claude Moraes MEP's committee on surveillance is admirably pursuing this agenda, member states remain unresponsive.