(n.) The hollow bed where a stream of water runs or may run.
(n.) The deeper part of a river, harbor, strait, etc., where the main current flows, or which affords the best and safest passage for vessels.
(n.) A strait, or narrow sea, between two portions of lands; as, the British Channel.
(n.) That through which anything passes; means of passing, conveying, or transmitting; as, the news was conveyed to us by different channels.
(n.) A gutter; a groove, as in a fluted column.
(n.) Flat ledges of heavy plank bolted edgewise to the outside of a vessel, to increase the spread of the shrouds and carry them clear of the bulwarks.
(v. t.) To form a channel in; to cut or wear a channel or channels in; to groove.
(v. t.) To course through or over, as in a channel.
Example Sentences:
(1) These channels may, at least in some cases, be responsible for the generation of pacemaker depolarizations, thereby regulating firing behaviour.
(2) The influence of the various concepts for the induction of lateral structure formation in lipid membranes on integral functional units like ionophores is demonstrated by analysing the single channel current fluctuations of gramicidin in bimolecular lipid membranes.
(3) RNAs encoding a wild-type (RBK1) and a mutant (RBK1(Y379V,V381T); RBK1*) subunit of voltage-dependent potassium channels were injected into Xenopus oocytes.
(4) The dramas are part of the BBC2 controller Janice Hadlow's plans for her "unashamedly intelligent" channel over the coming months.
(5) This was unlike the action of the calcium channel blocker, cadmium, which reduced the calcium action potential and the a.h.p.
(6) Circuitry has been developed to feed the output of an ear densitogram pickup into one channel of a two-channel Holter monitor.
(7) It is concluded the decrease in cellular volume associated with substitution of serosal gluconate for Cl results in a loss of highly specific Ba2+-sensitive K+ conductance channels from the basolateral plasma membrane.
(8) Stimulation of atrial H1-receptors is suggested to directly cause an increase in Ca-channel conductance independent of intracellular cAMP content.
(9) Similarly, 50 microM D-600, a Ca+2 channel antagonist, significantly (P less than 0.01) reduced basal and 5-HETE-induced PRL release.
(10) The purpose of the present study was to analyze the effects of cromakalim (BRL 34915), a potent drug from a new class of drugs characterized as "K+ channel openers", on the electrical activity of human skeletal muscle.
(11) This promotion of repetitive activity by the introduction of additional potassium channels occurred up to an "optimal" value beyond which a further increase in paranodal potassium permeability narrowed the range of currents with a repetitive response.
(12) Channel activation persists through the process of platelet isolation and washing and is manifested in higher measured values of [Ca2+]cyt and [Ca2+]dt in the "resting state."
(13) At 100 microM-ACh the apparent open time became shorter probably due to channel blockade by ACh molecules.
(14) The effects of low doses of dihydropyridine (DHP) calcium channel antagonists nimodipine, nifedipine, (-)-R-202-791, and amlodipine, the DHP calcium channel agonist BAY K 8644 were investigated on clonic convulsions to pentylenetetrazole (PTZ) in mice.
(15) The following model is suggested: exogenous ATP interacts with a membrane receptor in the presence of Ca2+, a cascade of events occurs which mobilizes intracellular calcium, thereby increasing the cytosolic free Ca2+ concentration which consequently opens the calcium-activated K+ channels, which then leads to a change in membrane potential.
(16) SDS-PAGE analysis of the immunoprecipitates under reducing conditions revealed that the cardiac channel is mainly composed of two large polypeptides of 190 and 150 kDa, and five smaller polypeptides of 60, 55, 35, 30, and 25 kDa.
(17) In the presence of high external Cl, a component of outward current that was inhibited by the anion channel blocker diphenylamine-2-carboxylate (DPC) appeared in 70% of the cells.
(18) In vitro studies in cardiac Purkinje fibers suggested that reversal of amitriptyline-induced cardiac membrane effects by sodium bicarbonate may be attributed not only to alkalinization but also to increased in extracellular sodium concentration, diminishing the local anesthetic action of amitriptyline and resulting in less sodium channel block.
(19) The Ca2+ channel current recorded under identical conditions in rat dorsal root ganglion neurones was less sensitive to blockade by PCP (IC50, 90 microM).
(20) In voltage-clamp experiments the ion current flowing through the channels was homogeneous indicating a defined conformation and a uniform size.
Side
Definition:
(n.) The margin, edge, verge, or border of a surface; especially (when the thing spoken of is somewhat oblong in shape), one of the longer edges as distinguished from the shorter edges, called ends; a bounding line of a geometrical figure; as, the side of a field, of a square or triangle, of a river, of a road, etc.
(n.) Any outer portion of a thing considered apart from, and yet in relation to, the rest; as, the upper side of a sphere; also, any part or position viewed as opposite to or contrasted with another; as, this or that side.
(n.) One of the halves of the body, of an animals or man, on either side of the mesial plane; or that which pertains to such a half; as, a side of beef; a side of sole leather.
(n.) The right or left part of the wall or trunk of the body; as, a pain in the side.
(n.) A slope or declivity, as of a hill, considered as opposed to another slope over the ridge.
(n.) The position of a person or party regarded as opposed to another person or party, whether as a rival or a foe; a body of advocates or partisans; a party; hence, the interest or cause which one maintains against another; a doctrine or view opposed to another.
(n.) A line of descent traced through one parent as distinguished from that traced through another.
(n.) Fig.: Aspect or part regarded as contrasted with some other; as, the bright side of poverty.
(a.) Of or pertaining to a side, or the sides; being on the side, or toward the side; lateral.
(a.) Hence, indirect; oblique; collateral; incidental; as, a side issue; a side view or remark.
(n.) Long; large; extensive.
(v. i.) To lean on one side.
(v. i.) To embrace the opinions of one party, or engage in its interest, in opposition to another party; to take sides; as, to side with the ministerial party.
(v. t.) To be or stand at the side of; to be on the side toward.
(v. t.) To suit; to pair; to match.
(v. t.) To work (a timber or rib) to a certain thickness by trimming the sides.
(v. t.) To furnish with a siding; as, to side a house.
Example Sentences:
(1) Previous use of the drug is found in more than 50 per cent of the patients, and it was often followed by a neglected side-effect.
(2) No differences between the two substances were observed with respect to side effects and general tolerability.
(3) During and after the infusion of 5HTP, none of the patients showed an increase in anxiety or depressive symptoms, despite the presence of severe side effects.
(4) gamma-Aminobutyric acid (GABA) and glutamate release from the treated side was higher than the control value during the first 2-3 h, a result indicating an important role of glial cells in the inactivation of released transmitter.
(5) The obvious need for highly effective contraception in women with existing disorders of glucose metabolism has led to a search for oral contraceptive (OC) regimens for such women that are efficient but without unacceptable metabolic side effects.
(6) Side effect incidence in patients treated with the paracetamol-sobrerol combination (3.7%) was significantly lower than that observed in subjects treated with paracetamol (6.1% - P less than 0.01), salicylics (25.1% - P less than 0.001), pyrazolics (12.6% - P less than 0.001), propionics (20.3%, P less than 0.001) or other antipyretics (17.9% - P less than 0.001).
(7) These findings suggest that clonidine transdermal disks lower blood pressure in hypertensive patients, but produce local skin lesions and general side effects.
(8) Completeness of isolation of the coronary and systemic circulations was shown by the marked difference in appearance times between the reflex hypotensive responses from catecholamine injections into the isolated coronary circulation and the direct hypertensive response from a similar injection when the circulations were connected as well as by the marked difference between the pressure pulses recorded simultaneously on both sides of the aortic balloon separating the two circulations.4.
(9) The Tyr side chain had two conformations of comparable energy, one over the ring between the Gln and Asn side chains, and the other with the Tyr side chain away from the ring.
(10) Estimates of potential for gastrointestinal side effects using the rat enteropooling assay and in vivo monkey effects indicate that diarrhea will be substantially reduced with retention of uterine stimulating potency.
(11) The reason for the rise in Android's market share on both sides of the Atlantic is the increased number of devices that use the software.
(12) Only those derivatives with a free amino group and net positive charge in the side chain were effective.
(13) Thus there may be four types of LPS in PACI: one contains unsubstituted core polysaccharide and yields L2 on acid hydrolysis, another has short antigenic side-chains of the SR type and yields the LI fraction, while the two high molecular weight fractions are derived from core polysaccharides with different side-chains.
(14) For retrospective action to be taken, and an FA charge to follow, the decision of the panel must be unanimous.” The match between the sides ended in acrimony and two City red cards.
(15) We studied the effect of low-dose intrathecal morphine (0.00-0.20 mg) on pain relief and the incidence of side effects after cholecystectomy in 139 patients divided into eight groups according to intrathecal morphine dose: groups 1 (0.00 mg), 2 (0.04 mg), 3 (0.06 mg), 4 (0.08 mg), 5 (0.10 mg), 6 (0.12 mg), 7 (0.15 mg), and 8 (0.20 mg).
(16) The temperature increased from the anterior to the posterior region on both buccal and lingual sides of both arches.
(17) The product of this enzymatic hydrolysis was F420 with one less glutamic acid in the side chain.
(18) On embryonic day 3.5 (E3.5), 1 day after surgery, there is a 42% average increase in volume of the polyganglia compared with the corresponding DRG on the unoperated side.
(19) Side effects were observed in 15.9% of the patients in the urapidil group and in 11.3% of the prazosin group (NS).
(20) Significant side-effects occurred infrequently and only 2 children lost weight during the period of medication.