(n.) The hollow bed where a stream of water runs or may run.
(n.) The deeper part of a river, harbor, strait, etc., where the main current flows, or which affords the best and safest passage for vessels.
(n.) A strait, or narrow sea, between two portions of lands; as, the British Channel.
(n.) That through which anything passes; means of passing, conveying, or transmitting; as, the news was conveyed to us by different channels.
(n.) A gutter; a groove, as in a fluted column.
(n.) Flat ledges of heavy plank bolted edgewise to the outside of a vessel, to increase the spread of the shrouds and carry them clear of the bulwarks.
(v. t.) To form a channel in; to cut or wear a channel or channels in; to groove.
(v. t.) To course through or over, as in a channel.
Example Sentences:
(1) These channels may, at least in some cases, be responsible for the generation of pacemaker depolarizations, thereby regulating firing behaviour.
(2) The influence of the various concepts for the induction of lateral structure formation in lipid membranes on integral functional units like ionophores is demonstrated by analysing the single channel current fluctuations of gramicidin in bimolecular lipid membranes.
(3) RNAs encoding a wild-type (RBK1) and a mutant (RBK1(Y379V,V381T); RBK1*) subunit of voltage-dependent potassium channels were injected into Xenopus oocytes.
(4) The dramas are part of the BBC2 controller Janice Hadlow's plans for her "unashamedly intelligent" channel over the coming months.
(5) This was unlike the action of the calcium channel blocker, cadmium, which reduced the calcium action potential and the a.h.p.
(6) Circuitry has been developed to feed the output of an ear densitogram pickup into one channel of a two-channel Holter monitor.
(7) It is concluded the decrease in cellular volume associated with substitution of serosal gluconate for Cl results in a loss of highly specific Ba2+-sensitive K+ conductance channels from the basolateral plasma membrane.
(8) Stimulation of atrial H1-receptors is suggested to directly cause an increase in Ca-channel conductance independent of intracellular cAMP content.
(9) Similarly, 50 microM D-600, a Ca+2 channel antagonist, significantly (P less than 0.01) reduced basal and 5-HETE-induced PRL release.
(10) The purpose of the present study was to analyze the effects of cromakalim (BRL 34915), a potent drug from a new class of drugs characterized as "K+ channel openers", on the electrical activity of human skeletal muscle.
(11) This promotion of repetitive activity by the introduction of additional potassium channels occurred up to an "optimal" value beyond which a further increase in paranodal potassium permeability narrowed the range of currents with a repetitive response.
(12) Channel activation persists through the process of platelet isolation and washing and is manifested in higher measured values of [Ca2+]cyt and [Ca2+]dt in the "resting state."
(13) At 100 microM-ACh the apparent open time became shorter probably due to channel blockade by ACh molecules.
(14) The effects of low doses of dihydropyridine (DHP) calcium channel antagonists nimodipine, nifedipine, (-)-R-202-791, and amlodipine, the DHP calcium channel agonist BAY K 8644 were investigated on clonic convulsions to pentylenetetrazole (PTZ) in mice.
(15) The following model is suggested: exogenous ATP interacts with a membrane receptor in the presence of Ca2+, a cascade of events occurs which mobilizes intracellular calcium, thereby increasing the cytosolic free Ca2+ concentration which consequently opens the calcium-activated K+ channels, which then leads to a change in membrane potential.
(16) SDS-PAGE analysis of the immunoprecipitates under reducing conditions revealed that the cardiac channel is mainly composed of two large polypeptides of 190 and 150 kDa, and five smaller polypeptides of 60, 55, 35, 30, and 25 kDa.
(17) In the presence of high external Cl, a component of outward current that was inhibited by the anion channel blocker diphenylamine-2-carboxylate (DPC) appeared in 70% of the cells.
(18) In vitro studies in cardiac Purkinje fibers suggested that reversal of amitriptyline-induced cardiac membrane effects by sodium bicarbonate may be attributed not only to alkalinization but also to increased in extracellular sodium concentration, diminishing the local anesthetic action of amitriptyline and resulting in less sodium channel block.
(19) The Ca2+ channel current recorded under identical conditions in rat dorsal root ganglion neurones was less sensitive to blockade by PCP (IC50, 90 microM).
(20) In voltage-clamp experiments the ion current flowing through the channels was homogeneous indicating a defined conformation and a uniform size.
Sink
Definition:
(v. i.) To fall by, or as by, the force of gravity; to descend lower and lower; to decline gradually; to subside; as, a stone sinks in water; waves rise and sink; the sun sinks in the west.
(v. i.) To enter deeply; to fall or retire beneath or below the surface; to penetrate.
(v. i.) Hence, to enter so as to make an abiding impression; to enter completely.
(v. i.) To be overwhelmed or depressed; to fall slowly, as so the ground, from weakness or from an overburden; to fail in strength; to decline; to decay; to decrease.
(v. i.) To decrease in volume, as a river; to subside; to become diminished in volume or in apparent height.
(v. t.) To cause to sink; to put under water; to immerse or submerge in a fluid; as, to sink a ship.
(v. t.) Figuratively: To cause to decline; to depress; to degrade; hence, to ruin irretrievably; to destroy, as by drowping; as, to sink one's reputation.
(v. t.) To make (a depression) by digging, delving, or cutting, etc.; as, to sink a pit or a well; to sink a die.
(v. t.) To bring low; to reduce in quantity; to waste.
(v. t.) To conseal and appropriate.
(v. t.) To keep out of sight; to suppress; to ignore.
(v. t.) To reduce or extinguish by payment; as, to sink the national debt.
(n.) A drain to carry off filthy water; a jakes.
(n.) A shallow box or vessel of wood, stone, iron, or other material, connected with a drain, and used for receiving filthy water, etc., as in a kitchen.
(n.) A hole or low place in land or rock, where waters sink and are lost; -- called also sink hole.
Example Sentences:
(1) Arterial-type flows produced a pair of vortex sinks downstream of the branching port.
(2) The compromised ice sheet tilts and he sinks into the Arctic Sea on the back of his faltering white Icelandic pony.
(3) These recent Times scoops about Obama's policies do not sink to the level of the Judy Miller debacle.
(4) Comparatively the virus strength sinks more slowly at 4 degrees C in the more mineralized river water (figure 2).
(5) Milk poured from higher (5-10cm above the cup) will sink beneath the surface.
(6) The chylomicrons in particular, become separated from the VLDL, the sinking pre-beta-lipoprotein or Lp (a) was identifiable and the type III hyperlipemia was easily diagnosed.
(7) It’s another squalid reminder of Conservative priorities, and how low they are prepared to sink in pursuit of them.
(8) Chinese drugs constitute a unique medicinal system that features the following three subsystems: subsystem of medicinal substances consisting of traditional theories such as "four properties and five tastes of drugs" and "the principal, adjuvant, auxiliary and conduct ingredients in a prescription' , etc; subsystem of pharmacological actions comprising the theory of "ascending, descending, floating and sinking", etc; Subsystem of human body's functions incorporating the theory of "drugs to act on the channels".
(9) In women, but not in men, there was a rise in the risk of falling from 45 years, peaking in the 55-59 year age group, and sinking to a nadir at ages 70-74.
(10) 81% of all sinks were contaminated with P. aeruginosa strains.
(11) During the early part of the experiments, when the sink condition was maintained, FAH was the most effective for hairless mouse skin, whereas Azone showed the highest effect in the rat skin.
(12) Opening of water taps generated aerosols containing P. aeruginosa sink organisms which contaminated hands during hand washing.
(13) Rats were classified into sinking and non-sinking groups, according to the appearance of sinking behavior over a 2 hr test.
(14) The laminar pattern of current sources and sinks coincident with this component was more complicated after bicuculline, reflecting the summation of current flows associated with disinhibited lamina 4 activity.
(15) But the reality of it began to sink in, and when I met with Kathy Kennedy [the Lucasfilm president and Star Wars executive producer], my gut said this is not something to reject.
(16) For here we see the depravity to which man can sink, the barbarity that unfolds when we begin to see our fellow human beings as somehow less than us, less worthy of dignity and life; we see how evil can, for a moment in time, triumph when good people do nothing."
(17) Waste eluates are collected and drained to the sink by a Teflon tray positioned between the columns and counting tubes, also held by the turntable.
(18) But it has been overwhelmed by the story of the sinking of the Sewol.
(19) Since biogenic particulate products, especially fecal pellets, are known to sink rapidly and intact to the ocean bottom, the transport of PCB's by such sinking particles could be an important mechanism which contributes to the penetration of PCB's into the deep sea.
(20) The receptor component had a current source in the outer segments (90% depth) and a sink in the ONL (70% depth).